Graphene solution-gated field effect transistor DNA sensor fabricated by liquid exfoliation and double glutaraldehyde cross-linking

Wang, Zhongrong; Jia, Yunfang

doi:10.1016/j.carbon.2018.01.078

Cited by 33 publications

(28 citation statements)

References 43 publications

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“…In Figure 4B, the lowest point is corresponding to the charge neutral point (V CNP ), the positively shifted V CNP points with the increasing of V DS are measured by rGO-COOH devices. This is in agreement with our works about liquid exfoliated graphene (LEG) based solution-gated field effect transistor (SgFET) [53]. However, in Figure 4C, V CNP points of rGO-FET are almost un-shaken and maintained at about 0.1 V. Besides, it is found that the pGp based SgFET has no ambipolar feature.…”

Section: Resultssupporting

confidence: 91%

“…The basic electronic examinations are executed on unmodified devices (blank) using the measuring setup given in Figure 1C. According to our previous works about GFETs [53], the testing ranges of V GS and V DS are in the range of −0.5–0.5V. The voltage of V DS are swept from −0.5 to +0.5 V, when V GS are maintained at the constant values 0.5, 0.3, 0.1V, respectively, as shown in Figure 4A.…”

Section: Resultsmentioning

confidence: 99%

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Reduced Carboxylate Graphene Oxide based Field Effect Transistor as Pb2+ Aptamer Sensor

Wang

Jia

2019

Micromachines

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Aptamer functionalized graphene field effect transistor (apta-GFET) is a versatile bio-sensing platform. However, the chemical inertness of graphene is still an obstacle for its large-scale applications and commercialization. In this work, reduced carboxyl-graphene oxide (rGO-COOH) is studied as a self-activated channel material in the screen-printed apta-GFETs for the first time. Examinations are carefully executed using lead-specific-aptamer as a proof-of-concept to demonstrate its functions in accommodating aptamer bio-probes and promoting the sensing reaction. The graphene-state, few-layer nano-structure, plenty of oxygen-containing groups and enhanced LSA immobilization of the rGO-COOH channel film are evidenced by X-ray photoelectron spectroscopy, Raman spectrum, UV-visible absorbance, atomic force microscopy and scanning electron microscope. Based on these characterizations, as well as a site-binding model based on solution-gated field effect transistor (SgFET) working principle, theoretical deductions for rGO-COOH enhanced apta-GFETs’ response are provided. Furthermore, detections for disturbing ions and real samples demonstrate the rGO-COOH channeled apta-GFET has a good specificity, a limit-of-detection of 0.001 ppb, and is in agreement with the conventional inductively coupled plasma mass spectrometry method. In conclusion, the careful examinations demonstrate rGO-COOH is a promising candidate as a self-activated channel material because of its merits of being independent of linking reagents, free from polymer residue and compatible with rapidly developed print-electronic technology.

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Section: Resultssupporting

confidence: 91%

Section: Resultsmentioning

confidence: 99%

Reduced Carboxylate Graphene Oxide based Field Effect Transistor as Pb2+ Aptamer Sensor

Wang

Jia

2019

Micromachines

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“…The substrate needs to be modified by glutaraldehyde and LPE graphene was drop-coated on top of the surface. The formation of a continuous film of carbon 2D material required a two times repetition [99]. To enhance the surface area, rGO was drop-casted onto a substrate to be used as channel material, providing a rough carbon layer.…”

Section: Field-effect Transistors and Chemiresistorsmentioning

confidence: 99%

Recent developments in carbon-based two-dimensional materials: synthesis and modification aspects for electrochemical sensors

Kirchner

Hirsch

2020

Microchim Acta

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This review (162 references) focuses on two-dimensional carbon materials, which include graphene as well as its allotropes varying in size, number of layers, and defects, for their application in electrochemical sensors. Many preparation methods are known to yield two-dimensional carbon materials which are often simply addressed as graphene, but which show huge variations in their physical and chemical properties and therefore on their sensing performance. The first section briefly reviews the most promising as well as the latest achievements in graphene synthesis based on growth and delamination techniques, such as chemical vapor deposition, liquid phase exfoliation via sonication or mechanical forces, as well as oxidative procedures ranging from chemical to electrochemical exfoliation. Two-dimensional carbon materials are highly attractive to be integrated in a wide field of sensing applications. Here, graphene is examined as recognition layer in electrochemical sensors like field-effect transistors, chemiresistors, impedance-based devices as well as voltammetric and amperometric sensors. The sensor performance is evaluated from the material’s perspective of view and revealed the impact of structure and defects of the 2D carbon materials in different transducing technologies. It is concluded that the performance of 2D carbon-based sensors is strongly related to the preparation method in combination with the electrical transduction technique. Future perspectives address challenges to transfer 2D carbon-based sensors from the lab to the market.

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“…In this study, the electrochemical analysis methods which are more cost-effective, have low sensitivity, and have less solvent consumption were applied for detection of IVM residual in BRT buffer solution, in tap water, and in urine sample. Glutaraldehyde or glutardialdehyde is used as a cross-linker for electrode modification in electrochemical sensor studies [ 28 – 30 ] and allows the sensor material to be immobilized to the electrode surface. İpek [ 31 ] used glutaraldehyde as a sensing element for the analysis of carbaryl pesticide.…”

Section: Introductionmentioning

confidence: 99%

Electrochemical Detection of Ivermectin Used for the Treatment of COVID-19 with Glutardialdehyde-Modified Glassy Carbon Electrode

Koçak

İpek

2022

Electrocatalysis

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Graphical abstract In this study, the surface of the glassy carbon electrode was modified with glutardialdehyde. The modified glassy carbon electrode showed electrocatalytic activity against ivermectin. The glassy carbon electrode modified with glutardialdehyde showed high sensitivity, selectivity, and stability in the determination of ivermectin. The peak current of glutardialdehyde oxidation obtained by differential pulse voltammetry decreased inversely with the ivermectin concentration. Ivermectin inhibited the oxidation reaction of glutardialdehyde and caused a decrease in current. This change made the analysis of ivermectin electrochemically possible. In order to demonstrate the applicability of the developed method in real samples, recovery studies were carried out in tap water and urine. The highest sensitivity (0.45 µA/((µmol·L −1 )(cm 2 ))) was achieved with urine sample and the lowest detection limit as 2.66 × 10 −6 mol·L −1 was obtained with BRT solution sample.

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Graphene solution-gated field effect transistor DNA sensor fabricated by liquid exfoliation and double glutaraldehyde cross-linking

Cited by 33 publications

References 43 publications

Reduced Carboxylate Graphene Oxide based Field Effect Transistor as Pb2+ Aptamer Sensor

Reduced Carboxylate Graphene Oxide based Field Effect Transistor as Pb2+ Aptamer Sensor

Recent developments in carbon-based two-dimensional materials: synthesis and modification aspects for electrochemical sensors

Electrochemical Detection of Ivermectin Used for the Treatment of COVID-19 with Glutardialdehyde-Modified Glassy Carbon Electrode

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