Grating-free quantitative phase retrieval for x-ray phase-contrast imaging with conventional sources

Sun, Weiyuan; Pyakurel, Uttam; MacDonald, Carolyn A.; Petruccelli, Jonathan C.

doi:10.1088/2057-1976/ac741d

Cited by 3 publications

(3 citation statements)

References 36 publications

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“…The small angle scatter creates spatially varying blur across the mesh image, so the reduction in the mesh contrast is taken as the dark field images. 7,8,9 Figure 1. Illustration of a mesh-based phase and dark field imaging system.…”

Section: Methodsmentioning

confidence: 99%

“…We employed deblurring techniques to enhance the image quality. 8,10,11 Deblurring corrects the DPC signal error due to a combined total blur, which is the aggregate of the geometrical blur due to the finite source size, and the blur related to the camera MTF. The mesh-based system simultaneously produces phase gradient, dark field, and reduced scatter attenuation images.…”

Section: Methodsmentioning

confidence: 99%

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Phase and dark field tomography with structured illumination

Allahyani,

Redgate,

MacDonald

et al. 2024

Medical Imaging 2024: Physics of Medical Imaging

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X-ray phase and dark field imaging offer two additional channels of information as well as providing information on material micro-texture that is unavailable to conventional x-ray imaging. We employ a single, low-cost, easily-aligned, coarse-pitched mesh to produce a pattern that is imaged directly. A number of reconstruction techniques were compared to produce phase and dark field computed tomography (CT) images of phantoms and human breast tissue.

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Section: Methodsmentioning

confidence: 99%

Section: Methodsmentioning

confidence: 99%

Phase and dark field tomography with structured illumination

Allahyani,

Redgate,

MacDonald

et al. 2024

Medical Imaging 2024: Physics of Medical Imaging

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“…The meshbased x-ray phase contrast imaging which exploits one single mesh to generate a periodically structured pattern that can be directly recognized by the detector takes the advantages of the above two techniques (Wen et al 2008, Bennett et al 2010. This method is also able to be applied to conventional x-ray tube with spot size up to 300 μm and the large period mesh in the system is easy to calibrate (Sun et al 2022). The transmission, DPC and DF images are reconstructed with one capture of the tested sample and another of the background using the spatial harmonic method.…”

Section: Introductionmentioning

confidence: 99%

Tri-directional x-ray phase contrast multimodal imaging using one hexagonal mesh modulator

Tao,

Tian,

Bai

et al. 2023

Phys. Med. Biol.

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Objective. X-ray phase contrast imaging is a promising technique for future clinical diagnostic as it can provide enhanced contrast in soft tissues compared to traditional X-ray attenuation-contrast imaging. However, the strict requirements on the X-ray coherence and the precise alignment of optical elements limit its applications towards clinical use. To solve this problem, mesh-based X-ray phase contrast imaging method with one hexagonal mesh is proposed for easy alignment and better image visualization. Approach. The mesh produces structured illuminations and the detector captures its distortions to reconstruct the absorption, differential phase contrast (DPC) and dark-field (DF) images of the sample. In this work, we fabricated a hexagonal mesh to simultaneously retrieve DPC and DF signals in three different directions with single shot. A phase retrieval algorithm to obtain artifacts-free phase from DPC images with three different directions is put forward and false color dark-field image is also reconstructed with tri-directional images. Mesh-shifting method based on this hexagonal mesh modulator is also proposed to reconstruct images with better image quality at the expense of increased dose. Main results. In numerical simulations, the proposed hexagonal mesh outperforms the traditional square mesh in image evaluation metrics performance and false color visualization with the same radiation dose. The experimental results demonstrate its feasiblity in real imaging systems and its advantages in quantitive imaging and better visualization. The proposed hexagonal mesh is easy to fabricate and can be successfully applied to X-ray source with it spot size up to 300μm. Significance. This work opens new possibilities for quantitative X-ray non-destructive imaging and may also be instructive for research fields such as X-ray structured illumination microscopy (SIM), X-ray spectral imaging and X-ray phase contrast and dark-field computed tomography (CT).

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X-ray Phase Contrast Imaging from Synchrotron to Conventional Sources: A Review of the Existing Techniques for Biological Applications

2022

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Since the seminal work of Roentgen, X-ray imaging mainly uses the same physical phenomenon: the absorption of light by matter. Thanks to third-generation synchrotrons that provide a high flux of quasi-coherent X-rays, we have seen in recent years new imaging concepts such as phase contrast or dark-field imaging that were later adapted to conventional X-ray sources. These innovative imaging techniques are particularly suitable for visualizing soft matter, such as biological tissues. After a brief introduction to the physical foundations of these two techniques, we present the different experimental set-ups that are now available to produce such contrasts: propagation, analyzer-based, grating interferometry and non-interferometric methods, such as coded aperture and modulation techniques. We present a comprehensive review of their principles; associated data processing; and finally, their requirements for their transfer outside of synchrotrons. In conclusion, gratings interferometry, coded aperture and modulation techniques seem to be the best candidates for the widespread use of phase contrast and dark-field imaging on low-cost X-ray sources.

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Grating-free quantitative phase retrieval for x-ray phase-contrast imaging with conventional sources

Cited by 3 publications

References 36 publications

Phase and dark field tomography with structured illumination

Phase and dark field tomography with structured illumination

Tri-directional x-ray phase contrast multimodal imaging using one hexagonal mesh modulator

X-ray Phase Contrast Imaging from Synchrotron to Conventional Sources: A Review of the Existing Techniques for Biological Applications

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