Gravesʼ hyperthyroidism in a patient with primary sclerosing cholangitis. Coincidence or combined pathogenesis?

Hl, Janssen; Ah, Smelt; Hoek, Bart van

doi:10.1097/00042737-199803000-00015

Cited by 18 publications

(9 citation statements)

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“…An increased prevalence rate for extrahepatic autoimmune disorders has been recognized in association with PSC 59. While IBD is the most common disorder, a number of patients will also develop pancreatitis (10% to 25%),60,61 diabetes mellitus (5% to 15%),59 and autoimmune thyroid disease (3% to 5%) 59,62. Rare associations include Sjogren's syndrome,61 immune thrombocytopenic purpura,63 retroperitoneal fibrosis,64 rheumatoid arthritis,65 Hodgkin's disease,66 glomerulonephritis,67,68 autoimmune hemolytic anemia,69 celiac disease,70–72 and Down's syndrome 73…”

Section: Clinical Featuresmentioning

confidence: 99%

Primary Sclerosing Cholangitis

Talwalkar

Lindor

2005

Inflammatory Bowel Diseases

114

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Primary sclerosing cholangitis (PSC) is a chronic cholestatic liver disease characterized by inflammation and fibrosis of the intra- and extrahepatic bile ducts. An estimated 80% of patients in North America and Europe have coexistent inflammatory bowel disease (IBD). The underlying pathophysiology of PSC remains poorly understood. As a result, there is currently no effective medical therapy to halt disease progression. Important complications from PSC include metabolic bone disease, colorectal neoplasia, and cholangiocarcinoma. Liver transplantation remains the only successful treatment option for patients with advanced liver disease from PSC. A diagnosis of PSC should be considered among individuals with IBD and elevated serum liver biochemical tests.

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Section: Clinical Featuresmentioning

confidence: 99%

Primary Sclerosing Cholangitis

Talwalkar

Lindor

2005

Inflammatory Bowel Diseases

114

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“…According to Casella et al [25], the first report of concomitant hyperthyroidism and UC was in 1968. We identified 27 reported cases of concomitant thyrotoxicosis and UC in English-and Japaneselanguage reports published since 1980 [1,3,[7][8][9][10]16,18,[25][26][27][28][29][30][32][33][34][35][36][37][38][39]. We excluded cases of concomitant UC and thyrotoxicosis caused by excessive supplementation of thyroxine after subtotal thyroidectomy for toxic adenoma, toxic multinodular goiter, or unknown causes.…”

Section: Characteristics Of Cases Of Concomitant Gd and Ucmentioning

confidence: 99%

“…We excluded cases of concomitant UC and thyrotoxicosis caused by excessive supplementation of thyroxine after subtotal thyroidectomy for toxic adenoma, toxic multinodular goiter, or unknown causes. In total, we identified 16 reported cases of concomitant GD and UC (eight in the English language [7,16,25,29,30,34,36] and eight in the Japanese language [1,3,18,[26][27][28]37,38] ). The characteristics of these 16 reported cases of concomitant GD and UC are summarized in Table 1.…”

Section: Characteristics Of Cases Of Concomitant Gd and Ucmentioning

confidence: 99%

“…(1) Oshitani et al [37] reported the case of a 53 year old female who developed UC, GD, and dermatomyositis within a 9 month period. (2) Janssen et al [34] reported the case of a 24 year old male who developed GD 5 years after the diagnosis of PSC and 7 years after the diagnosis of UC. (3) Ku et al [36] reported the case of a 38 year old female who developed GD and focal proliferative glomerulonephritis secondary to IgA nephropathy 20 years after the diagnosis of UC.…”

Section: Case Reports Of Concomitant Gd and Ucmentioning

confidence: 99%

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Coexistence of Graves’ Disease (Basedow’s Disease) and Ulcerative Colitis

Shizuma¹

2014

Intern Med

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The coexistence of Graves' disease (GD), also known as Basedow's disease, and ulcerative colitis (UC) is uncommon although both conditions involve the autoimmune process. This report reviews the English-and Japanese-language literature on coexisting hyperthyroidism and UC, and discusses cases of concomitant GD and UC reported since 1980. Of the 16 cases of concomitant GD and UC that were identified, 10 were female (62.5%). In one case (6.3%), GD and UC were simultaneously diagnosed. In nine cases (56.3%) GD developed before UC and in six cases (37.5%) UC developed before GD. The time interval between the development of the primary and the concomitant disease was 0-20 years. Most cases of concomitant GD and UC were treated with pharmacotherapy and there were no deaths reported.

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“…Several autoimmune disorders have been associated with the diagnosis of primary sclerosing cholangitis (PSC), including hyperthyroidism41 coeliac disease42 and dermatitis herpetiformis 43…”

Section: Clinical Features and Diagnosismentioning

confidence: 99%

Diagnosis of primary sclerosing cholangitis

Harrison

1999

Journal of Hepato-Biliary-Pancreatic Surgery

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Primary sclerosing cholangitis is a progressive chronic hepatobiliary disorder of unknown aetiology for which no effective medical therapy currently exists. This syndrome occurs most commonly in young men and is frequently associated with ulcerative colitis. Primary sclerosing cholangitis should be considered in the differential diagnosis of all patients presenting with chronic cholestasis. The diagnosis is based on a combination of the clinical features and cholestatic biochemical profile accompanied by typical cholangiographic abnormalities and is supported by liver histology findings. The major diagnostic criterion is the finding at cholangiography of irregularly distributed multifocal strictures within both the intrahepatic and extrahepatic bile ducts. The most characteristic histological feature of primary sclerosing cholangitis is periductal concentric obliterative fibrosis of small interlobular bile ducts with or without proliferation of bile ducts in portal tracts, but liver biopsy findings alone are infrequently diagnostic. Nevertheless, liver histology remains important to exclude other causes of chronic cholestasis and in staging the disease.

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Gravesʼ hyperthyroidism in a patient with primary sclerosing cholangitis. Coincidence or combined pathogenesis?

Cited by 18 publications

References 0 publications

Primary Sclerosing Cholangitis

Primary Sclerosing Cholangitis

Coexistence of Graves’ Disease (Basedow’s Disease) and Ulcerative Colitis

Diagnosis of primary sclerosing cholangitis

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