Graviola attenuates DMBA-induced breast cancer possibly through augmenting apoptosis and antioxidant pathway and downregulating estrogen receptors

Zeweil, Mohamed M.; Sadek, Kadry M.; Taha, Nabil M.; El‐Sayed, Yasser S.; Menshawy, Sherif

doi:10.1007/s11356-019-04920-w

Cited by 36 publications

(37 citation statements)

References 68 publications

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“…DMBA, which is used to induce experimental breast carcinomas in rats, affects various biochemical and physiopathological processes and causes oxidative damage by disrupting tissue redox balance (13). As a result, DMBA increases the formation of reactive oxygen species (ROS) and causes oxidative stress (14). Increased oxidative stress plays a role in carcinogenesis (15).…”

Section: Discussionmentioning

confidence: 99%

Zinc and melatonin supplementation ameliorates brain cortex tissue damage in DMBA-induced breast cancer in rats

Mutlu¹,

Baltaci²

2020

BLL

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BACKGROUND: This study aims to investigate the effects of zinc and melatonin supplementation on lipid peroxidation in the brain cortex in DMBA-induced breast cancer in female rats. METHODS: A total of 42 recently weaned Wistar rats were divided into 5 groups as follows: Control (Group 1), DMBA Control (Group 2), DMBA+Zinc (Group 3), DMBA+Melatonin (Group 4), DMBA+Melatonin & Zinc (Group 5). At the end of the study, all animals were sacrifi ced by decapitation and Malondialdehyde (MDA) and glutathione (GSH) levels in brain cortex tissue samples were determined via spectrophotometric methods. RESULTS: The highest MDA levels were in the DMBA-treated group (Group 2) (p < 0.05). MDA levels in Group 3, Group 4, and Group 5 were signifi cantly lower than in group 2 (p < 0.05). Also, GSH levels in group 3, 4, and 5 were signifi cantly higher than in group 2 (p < 0.05). CONCLUSION: There are no reports on whether DMBA-induced experimental breast cancer affects oxidative stress in brain tissue. In this respect, our study revealed that the increased brain cortex tissue damage in DMBA-induced breast cancer is alleviated by Zinc, melatonin, or combined zinc and melatonin treatment

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Section: Discussionmentioning

confidence: 99%

Zinc and melatonin supplementation ameliorates brain cortex tissue damage in DMBA-induced breast cancer in rats

Mutlu¹,

Baltaci²

2020

BLL

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“…It also destroys DNA structure and causes lipid peroxidation. It has been reported to exert a carcinogenic effect by increasing the formation of free radicals such as intracellular hydroxyl and superoxide anion radicals (Giovanni et al, 1980;Gao et al, 2007;Zeweil et al, 2019).…”

Section: Introductionmentioning

confidence: 99%

Protective Effects of Grape Molasses and Resveratrol Against DMBA Induced Oxidative Stress in Rat Ovarian Tissues

Kıran

Otlu

Karabulut

et al. 2019

Middle Black Sea Journal of Health Science

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The polyphenolic compound, resveratrol (3, 4', 5-trihydroxystilbene), trans-resveratrol is a natural phytoalexin that exists in many different foods such as grape peel and seed, peanut, mulberry and blueberry. Molasses is a natural food obtained by boiling and concentrating fruit juices known to be rich in minerals such as iron, phosphorus, potassium, sodium, calcium and magnesium, and phosphoric acid, formic acid, organic acids and some vitamins. Polyphenolic compounds are natural antioxidants and are known to have protective effects against tissue damage caused by reactive oxygen species (ROS). In this study, we aimed to investigate the protective effects of grape molasses and resveratrol on ovarian damage induced by 7, 12-dimethylbenz [a] anthracene (DMBA). Methods: A total of 42 old female Wistar Albino rats, aged 18 weeks were divided into six groups. 10 mg/kg DMBA was injected in the rats in DMBA group subcutaneously on day 0 and day 7 while grape molasses feed with 20% grape molasses was given along with DMBA application to the rats in DMBA + grape molasses group. Resveratrol was administered by subcutaneous injection at 10 mg/kg/day to the DMBA + Resveratrol group, while only feed with 20% grape molasses was given to the grape molasses group. Resveratrol was administered by subcutaneous injection at 10 mg/kg/day to the resveratrol group. Results: GSH activity between the control group and molasses group, DMBA and DMBA + molasses groups and the control group and the DMBA + grape molasses groups was found statistically significant. Regarding the NO activity, the difference between the DMBA and resveratrol groups, DMBA and DMBA + resveratrol groups and the grape molasses and resveratrol groups was found statistically significant. MDA activity between DMBA + resveratrol and DMBA + grape molasses groups, and DMBA + grape molasses and grape molasses groups was found statistically significant. Conclusion: Molasses as one of the most important nutrient sources of Eastern and Central Anatolia was observed to decrease ovarian tissue oxidative damage induced with DMBA compared to resveratrol.

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“…[45] Reactive oxygen species (ROS) immediately destroys the major cell components, including proteins, lipids, and DNA. [46][47][48][49] In addition, the cardiac muscle mitochondria contain cardiolipin, which exhibits a high binding affinity for DOX, resulting in DOX accumulation, disruption of the respiratory chain, and cell death. [50] F Rb.…”

Section: Discussionmentioning

confidence: 99%

Proanthocyanidin alleviates doxorubicin‐induced cardiac injury by inhibiting NF‐kB pathway and modulating oxidative stress, cell cycle, and fibrogenesis

Sadek

Mahmoud

Zeweil

et al. 2021

J Biochem & Molecular Tox

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This study investigated the potential mechanism(s) and the signaling pathway(s) underlying the prophylactic effect of proanthocyanidin extract (PE) against doxorubicin (DOX)‐induced cardiotoxicity in rats. A total of 32 male albino rats were randomly allocated into four groups. Control rats were orally administrated normal saline. Rats in the second group were orally administrated PE (50 mg/kg bw/once daily) for 4 weeks. Rats in the third group were intraperitoneally injected with DOX (10 mg/kg on Days 3, 9, 15, and 21 of the experiment). Rats in the fourth group were injected with DOX and PE simultaneously for 4 weeks. DOX significantly augmented the levels of serum heart damage biomarkers. In addition, histopathology indicated that DOX‐induced cardiac tissue injury upregulated the expression of fibrogenic factors, alpha smooth muscle actin (α‐SMA), transforming growth factor β1 (TGF‐ β1), and p16INK4A. Downregulation of cell proliferation markers, cyclin‐dependent kinase‐4 (CDK4), and retinoblastoma (Rb) was also observed. Furthermore, DOX‐induced oxidative and inflammatory stress resulted in increased cardiac malondialdehyde (MDA), protein carbonyl (PC), interleukin‐2 (IL‐2), interleukin‐6 (IL‐6), and tumor necrosis factor‐alpha (TNF‐α). Decreased cardiac glutathione (GSH) levels and enzyme activity of catalase (CAT), superoxide dismutase (SOD), and glutathione S‐transferase (GST) were observed. Treatment of DOX‐induced rat cardiotoxicity with PE normalized serum parameters for the aforementioned parameters and alleviated cardiac tissue structure. Furthermore, reduced cardiac tissue α‐SMA and TGF‐β1, and increased CDK4 and Rb protein expression, along with the amelioration of oxidative and inflammatory effects were observed. PE attenuates DOX‐induced cardiomyocyte inflammation possibly by attenuating the nuclear factor kappa‐B (NF‐ kB) signaling pathway. These results indicate that PE may be useful as a preventative agent against DOX‐induced cardiac toxicity.

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Graviola attenuates DMBA-induced breast cancer possibly through augmenting apoptosis and antioxidant pathway and downregulating estrogen receptors

Cited by 36 publications

References 68 publications

Zinc and melatonin supplementation ameliorates brain cortex tissue damage in DMBA-induced breast cancer in rats

Zinc and melatonin supplementation ameliorates brain cortex tissue damage in DMBA-induced breast cancer in rats

Protective Effects of Grape Molasses and Resveratrol Against DMBA Induced Oxidative Stress in Rat Ovarian Tissues

Proanthocyanidin alleviates doxorubicin‐induced cardiac injury by inhibiting NF‐kB pathway and modulating oxidative stress, cell cycle, and fibrogenesis

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