We perform a detailed study of the grand unified theories SO (10) and E(6) with left-right intermediate gauge symmetries of the form SU (N ) L ⊗ SU (N ) R ⊗ G. Proton decay lifetime constrains the unification scale to be 10 16 GeV and, as discussed in this paper, unwanted cosmological relics can be evaded if the intermediate symmetry scale is 10 12 GeV. With these conditions, we study the renormalisation group evolution of the gauge couplings and do a comparative analysis of all possible left-right models where unification can occur. Both the D-parity conserved and broken scenarios as well as the supersymmetric (SUSY) and Non-supersymmetric (Non-SUSY) versions are considered. In addition to the fermion and scalar representations at each stage of the symmetry breaking, contributing to the β-functions, we list the intermediate left-right groups which successfully meet these requirements. We make use of the dimension-5 kinetic mixing effective operators for achieving unification and large intermediate scale. A significant result in the supersymmetric case is that to achieve successful unification for some breaking patterns, the scale of SUSY breaking needs to be at least a few TeV. In some of these cases, intermediate scale can be as low as ∼ 10 12GeV, for SUSY scale to be ∼ 30 TeV. This has important consequences in the collider searches for SUSY particles and phenomenology of the lightest neutralino as dark matter. *