Greater insulin response to acute fructose ingestion among Māori and Pacific people compared to European people living in Aotearoa New Zealand

Abstract

Background: Fructose consumption has been linked with insulin resistance, obesity and diabetes, which are more prevalent in those of M aori or Pacific ethnicity compared to New Zealand European.Aim: To determine whether the acute effects of fructose consumption on serum glucose, insulin, lipids and C-reactive protein differs according to body mass index (BMI) and/or ethnicity.Methods: Participants of M aori (n = 25), Pacific (n = 26) or New Zealand European (n = 25) ethnicity consumed a 64 g fructose/16 g glucose solution. Changes in lipids, glucose, insulin and C-reactive protein were analysed using mixed models for repeated measures.Results: After adjustment for age and gender, those with higher BMI had a higher glucose (P = 0.0064) and insulin (P = 0.0007) response than those with lower BMI. Those of M aori or Pacific ethnicity had similar glucose levels (P = 0.077) to those of New Zealand European ethnicity but higher insulin responses (P = 0.0005), which remained after additional adjustment for BMI (P = 0.001). Reported sugar-sweetened beverages (SSB) intake was higher among M aori and Pacific than New Zealand European (median 1.0 vs 0.0 SSB/day P = 0.002).Conclusion: Even after adjustment for BMI, those of M aori and Pacific ethnicity have a significantly higher insulin response to fructose than New Zealand Europeans. Higher habitual SSB intake may be a contributing factor.Values are mean (standard deviation) unless stated as median (interquartile range). BMI, body mass index; BP, blood pressure; CRP, C-reactive protein; HDL, high-density lipoprotein cholesterol; HOMA-IR, homeostatic model of assessment-insulin resistance; LDL, low-density lipoprotein cholesterol; NA, not applicable; SSB, sugar sweetened beverages.Metabolic response to acute fructose

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