Greater therapeutic efficacy of prednisolone plus medicinal herbs than prednisolone or medicinal herbs alone in patients with oral lichen planus

Chiu, Chang-Ta; Chuang, Ching-Ya; Li, Jau-Rong; Huang, Hsuan‐Ying; Chang, Sung-Wen; Hung, Yu‐Chiang

doi:10.1016/j.jds.2010.11.004

Cited by 10 publications

(7 citation statements)

References 42 publications

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“…Ear thickness was measured 5 h after croton oil treatment, and increase in thickness after croton oil treatment was considered as formation of edema. Prednisolone, commonly employed and useful agents to treat the inflammatory disorders, was used as a reference steroidal anti-inflammatory drug in this study (Chiu et al, 2010). Statistical analysis.…”

Section: Methodsmentioning

confidence: 99%

Inhibitory Effect of Sargauum fulvellum Ethanolic Extract on LPS-Induced Inflammatory Reaction in RAW 264.7 Mouse Macrophages

Kim¹,

Kim²,

Jeong³

et al. 2013

Journal of Applied Biological Chemistry

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Recently, algae has been considered as a potential antiinflammatory source due to its distinctive habitat environment exposing to light and high oxygen concentration. In present study, anti-inflammatory effect of brown alga, Sargassum fullvellum ethanol extract (SFEE), was examined. SFEE inhibited not only the production of nitric oxide and pro-inflammatory cytokines (IL-6, IL-1β, TNF-α) but also the expression of inducible nitric oxide synthase and cyclooxygenase 2 in LPS-induced RAW 264.7 cells without affecting cell viability. SFEE also suppressed the expression of nuclear factor kappa B (NF-κB), suggesting that SFEE could affect the expression of inflammation related cytokines and proteins through the regulation of NF-κB. Furthermore, formation of edema of the ear was 40% lower in mice treated with the highest dose (250 mg/kg) of SFEE than in the control mice. Thus, our study showed that SFEE may be a potential therapeutic anti-inflammatory drug.

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Section: Methodsmentioning

confidence: 99%

Inhibitory Effect of Sargauum fulvellum Ethanolic Extract on LPS-Induced Inflammatory Reaction in RAW 264.7 Mouse Macrophages

Kim¹,

Kim²,

Jeong³

et al. 2013

Journal of Applied Biological Chemistry

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“…Clinically and histopathologically diagnosed OLP patients received capsule lycopene 4 mg/day (LycoRed 2 mg capsule, Jagsonpal Pharmaceuticals, New Delhi, India) orally for 8 consecutive weeks. On each appointment, the reduction of the Thongprasom clinical sign scores was recorded based on the criterion described and modified by Thongprasom et al [11,12] as shown in Table 1.…”

Section: Methodsmentioning

confidence: 99%

“…Patients were asked open-ended questions to ascertain the nature and severity of any adverse effects. Statistical software package SPSS 11 version (SPSS Inc., Chicago, IL, USA) Table 1: Clinical sign scores based on Thongprasom criterion [11,12]…”

Section: Methodsmentioning

confidence: 99%

Clinical assessment of the effects of lycopene in the management of oral lichen planus

Kushwaha¹,

Rauniar²,

Rimal³

2019

IDJAR

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Background: Oral lichen planus (OLP) is a common subacute, chronic inflammatory mucocutaneous disease of the oral mucosa with unknown etiopathogenesis. Currently, the antioxidants such as retinoids, β-carotenoids, Aloe vera, purslane, turmeric, and lycopene are being successfully used in the treatment of OLP lesions, suggesting the role of oxidative stress in the pathogenesis of OLP. Aims: The aim of this study was to assess the clinical effects of lycopene in the management of OLP lesions. Materials and Methods: After obtaining written informed consent, 13 patients with symptomatic OLP and proven by biopsy were received capsule lycopene 4 mg/day for 8 consecutive weeks. The assessment was done at 0, 2, 4, 6, and 8 weeks of the interval using Thongprasom clinical sign scores to record the improvement in the clinical sign and symptoms of OLP lesions. Complete remission of the disease was defined as a complete absence of symptom and clinical sign scores of OLP lesions. Results: Among 13 patients, seven patients were male. The age ranged from 27 to 74 years. At baseline, the mean Thongprasom clinical sign score was 2.77 ± 1.74 that became 0.85 ± 0.37 (69%) after 8 weeks of treatment with lycopene, which was statistically significant (P = 0.005). Complete remission of the lesions was seen in two patients, and partial remission was seen in 11 patients after 8 consecutive weeks of treatment with lycopene. Conclusion: The result of this study was encouraging. In contrast to other management modalities for OLP, lycopene offers a safe, efficacious, and reliable treatment that yields a significant improvement in the signs and symptoms of the patients, which may be due to its antioxidant and anti-inflammatory activity. Therefore, lycopene can be recommended as a good treatment option in the prevention and management of OPL lesions. Clinical Significance: Finding from this study may help the dentist and clinician to choose lycopene as an alternative drug with less reported adverse effect for the effective management and prevention of OLP lesions.

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“…In China and Taiwan, herbal medicine is often used to treat the inflammation of the mucous membranes of the mouth to reduce the side effects of chemical drugs (Chiu et al, ). Various studies have been conducted to compare the effects of herbal medicine with corticosteroids and the efficiency of their combination in treating the disease as well.…”

Section: Introductionmentioning

confidence: 99%

“…It is also used to treat many oral diseases, especially in Asian countries such as China and Taiwan (Zheng, Hua, & Cheung, ). They use traditional medicine to treat the ulcer and chronic inflammation of oral mucosa (Chiu et al, ).TCM that is commonly used to treat oral diseases includes Liuwei Dihuang, Tripterygium glycosides, and Zengshengping (Zheng et al, ).…”

Section: Introductionmentioning

confidence: 99%

Herbal medicine in oral lichen planus

Ghahremanlo

Boroumand

Ghazvini

et al. 2018

Phytotherapy Research

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Oral lichen planus (OLP) is a common chronic inflammatory and T cell‐mediated autoimmune disease in which the oral mucosa, tongue, and gingiva are involved. Different treatments have been suggested to reduce the symptoms of this disease. Currently, a common treatment for OLP is the use of corticosteroids as the gold standard, although they have considerable side effects. The chronicity of the disease needs the long‐term use of these drugs with ensuing side effects. Therefore, various studies have been done to find an alternative and effective treatment. The use of herbal medicine as an alternative therapy with antioxidant and anti‐inflammatory properties seems promising. Hence, this review study was done to summarize the efficiency of different herbal medicine in the treatment of OLP.

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Greater therapeutic efficacy of prednisolone plus medicinal herbs than prednisolone or medicinal herbs alone in patients with oral lichen planus

Cited by 10 publications

References 42 publications

Inhibitory Effect of Sargauum fulvellum Ethanolic Extract on LPS-Induced Inflammatory Reaction in RAW 264.7 Mouse Macrophages

Inhibitory Effect of Sargauum fulvellum Ethanolic Extract on LPS-Induced Inflammatory Reaction in RAW 264.7 Mouse Macrophages

Clinical assessment of the effects of lycopene in the management of oral lichen planus

Herbal medicine in oral lichen planus

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