Greco-Arab and Islamic Herbal-Derived Anticancer Modalities: From Tradition to Molecular Mechanisms

Zaid, Hilal; Silbermann, Michael; Ben‐Arye, Eran; Saad, Bashar

doi:10.1155/2012/349040

Cited by 51 publications

(70 citation statements)

References 138 publications

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“…Active ingredients are described as constituents of herbal medicine with therapeutic activity and include carbohydrates, glycosides, lignanoids, alkaloids, amino acids, peptides, proteins and enzymes [83]. Many studies have already mentioned the biological activities of natural preparations such as the induction of the immune system and anti-inflammatory, antioxidant, antimicrobial, antimutagenic, anticancer and antiulcer effects [84]. …”

Section: Discussionmentioning

confidence: 99%

Skin Wound Healing and Phytomedicine: A Review

Pazyar

Yaghoobi²,

Rafiee³

et al. 2014

Skin Pharmacol Physiol

207

137

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Skin integrity is restored by a physiological process aimed at repairing the damaged tissues. The healing process proceeds in four phases: hemostasis, inflammation, proliferation and remodeling. Phytomedicine presents remedies, which possess significant pharmacological effects. It is popular amongst the general population in regions all over the world. Phytotherapeutic agents have been largely used for cutaneous wound healing. These include Aloe vera, mimosa, grape vine, Echinacea, chamomile, ginseng, green tea, jojoba, tea tree oil, rosemary, lemon, soybean, comfrey, papaya, oat, garlic, ginkgo, olive oil and ocimum. Phytotherapy may open new avenues for therapeutic intervention on cutaneous wounds. This article provides a review of the common beneficial medicinal plants in the management of skin wounds with an attempt to explain their mechanisms.

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Section: Discussionmentioning

confidence: 99%

Skin Wound Healing and Phytomedicine: A Review

Pazyar

Yaghoobi²,

Rafiee³

et al. 2014

Skin Pharmacol Physiol

207

137

View full text Add to dashboard Cite

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“…In muscle and hepatic and adipose tissues, insulin promotes the exocytic traffic of intracellular GLUT4 vessels towards the plasma membrane to elicit a rapid increase in glucose uptake (Osorio-Fuentealba and Klip, 2015;Zaid et al, 2008;Zierath et al, 1996). In insulin resistance and type 2 diabetes, insulin fails to promote GLUT4 translocation to the PM, and some of the antidiabetic synthetic drugs and medicinal plants-based products bypass the insulin resistance by increasing GLUT4 translocation in insulin dependent and independent pathways (Zaid et al, 2012). The involvement of glucose transporter (GLUT4) in the observed antidiabetic effects of T. polium extracts was evaluated by applying the GLUT4 translocation assay.…”

Section: Effects Of Teucrium Polium Extracts On Glut4 Translocationmentioning

confidence: 99%

Teucrium polium extracts stimulate GLUT4 translocation to the plasma membrane in L6 muscle cells

Kadan¹,

Sasson²,

Abu‐Reziq³

et al. 2018

Adv Med Plant Res

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Teucrium polium L. (TP) is recommended by herbal and integrative practitioners for the treatment of diabetes. However, its mechanism of action in stimulating GLUT4 activity and translocation to the plasma membrane is still unknown. This in vitro study examined the chemical composition, cytotoxicity, and antidiabetic activity of three TP distinct extracts: water/ethanol (WTP), methanol (MTP), and hexane (HTP). The compositions of the TP extracts were determined by GC/MS. MTT and LDH assays were used to assess the toxicity of the extracts. The efficacies of the TP extracts in enhancing glucose transporter-4 (GLUT4) translocation to plasma membrane (PM) were tested in L6 muscle cells, stably expressing myctagged GLUT4 using the cell-ELISA test. GC/MS phytochemical analysis of MTP and HTP extracts revealed 10 compounds in each extract, and only palmitic acid was communal in these two extracts. WTP, MTP, and HTP extracts were safe up to 63, 63, and 250 µg/ml, respectively. The HTP extract was the most efficient in GLUT4 translocation enhancement, while the least efficient was the WTP extract. In addition, the HTP extract increased the GLUT4 translocation at 32 µg/ml by 2-and 3-fold relative to the control in the absence and presence of insulin, respectively. A similar result was obtained with the MTP extract at 63 µg/ml. In contrast, WTP extract in the presence of insulin had no effect and in the absence of insulin had slightly enhanced GLUT4 translocation. These findings indicate that TP antidiabetic activity is mediated in part by enhancing GLUT4 translocation to the PM in skeletal muscle.

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“…Saffron is a sacred plant, a part of Arab-Islamic healing, 16 and used for writing verses of the Holy Quran. 17 Thus, it might not be unexpected that in this Muslim population, most were aware of and were using saffron.…”

Section: Discussionmentioning

confidence: 99%

A Representative Survey of Knowledge, Use, Perceived Benefits, Barriers, and Risks of Select Herbal Drugs Among Female Students in Gorgan City (Northeast Iran)

Ghanbari

Lotfalinezhad

et al. 2016

J Evid Based Complementary Altern Med

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We conducted a representative survey among young women to determine knowledge, use, and perceptions on barriers, benefits, and risks related to selected herbal drugs (Crocus sativus, Borago officinalis, Citrus aurantium, Thymus vulgaris, Matricaria chamomilla, Lavandula angustifolia, Valeriana officinalis, Hypericum perforatum, and Panax ginseng) in Gorgan by using an internally validated questionnaire. There were 344 participants (mean age 16.3 years; 16.2% in science course). Saffron had most reported knowledge (n ¼ 265, 77.0%) and ever use (n ¼ 324, 94.1%). The average number of source of knowledge was 2.5; parents (n ¼ 224, 65.1%) were the single most frequent source. Media (combined magazine, the Internet, TV, radio) was the source of knowledge for 283 (82.2%) participants. Actual use was ''harmful'' for the majority (n ¼ 182, 52.9%; no idea n ¼ 83, 24.1%). Parents and media provided knowledge on herbal drugs for most, supporting unsurprisingly high perceived knowledge but harmful actual experience. Programs to educate people are needed to not take herbal drugs lightly.

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Greco-Arab and Islamic Herbal-Derived Anticancer Modalities: From Tradition to Molecular Mechanisms

Cited by 51 publications

References 138 publications

Skin Wound Healing and Phytomedicine: A Review

Skin Wound Healing and Phytomedicine: A Review

Teucrium polium extracts stimulate GLUT4 translocation to the plasma membrane in L6 muscle cells

A Representative Survey of Knowledge, Use, Perceived Benefits, Barriers, and Risks of Select Herbal Drugs Among Female Students in Gorgan City (Northeast Iran)

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