Green and efficient synthesis of novel bispyrazoles through a tandem Knoevenagel and Michael type reaction using nanowire zinc oxide as a powerful and recyclable catalyst

Abstract

Zinc oxide nanowires (ZnO NWs) were prepared and characterized by scanning electron microscopy, powder X-ray diffraction, and transmission electron microscopy analyses. ZnO NWs were then employed as heterogeneous and recyclable catalyst for green synthesis of some new and known bispyrazole derivatives through a tandem Knoevenagel and Michael type addition reaction of aromatic aldehyde and pyrazolone. The synthetic method is operationally simple and affords product with high yields in short reaction times.

Insights into 4,4′‐Arylmethylene‐Bis‐1H‐Pyrazol‐5‐Ols Scaffolds: Various Synthetic Routes and Their Applications

“…The synthetic method is functionally simple, and yield of products are good yields in short reaction time (Scheme 15). [66] In the present work Eskandari et al disclose an expeditious and newer strategy for the condensation of ( 1) with ( 2) in H 2 O/ EtOH and of Mohr's salt as an eco-friendly and predominate, catalyst to give new (3) successfully accomplished via Knoevenagel-Michael reaction. The high efficiency, operational simplicity, minimum reaction time, outstanding yields, high rate, and environmental safety are noticeable advantages of this procedure (Scheme 16).…”

“…The synthetic method is functionally simple, and yield of products are good yields in short reaction time (Scheme 15). [66] …”

Unraveling the Anticancer Potential of Cinnamonitrile Derivatives: In vitro Evaluation and Molecular Docking

“…This transformative chemical reaction culminates in the creation of α,β‐unsaturated compounds through condensing carbonyl‐bearing compounds with those possessing activated methylene [4,5] . The Knoevenagel reaction has lent its prowess to myriad studies, facilitating the synthesis of a diverse array of organic compounds, many of which exhibit compelling biological activities [6–9] …”

“…[4,5] The Knoevenagel reaction has lent its prowess to myriad studies, facilitating the synthesis of a diverse array of organic compounds, many of which exhibit compelling biological activities. [6][7][8][9] The profound biological potential of α,β-unsaturated compounds has cast them as captivating molecules, beckoning the interest of chemists and pharmacologists. These compounds have showcased an extensive and diverse spectrum of biological activities, spanning anti-nociception through TREK-1 channel modulation, [10,11] inhibition of 12-Lipoxygenase, [12] acaricidal-fungicidal attributes, [13] antagonism of NMDA receptors, [14] and therapeutic potential for circulatory system diseases.…”