Green and facile synthesis of MOF and nano MOF containing zinc(II) and benzen 1,3,5-tri carboxylate and its study in ibuprofen slow-release

Toward Understanding Drug Incorporation and Delivery from Biocompatible Metal–Organic Frameworks in View of Cutaneous Administration

“…The release profiles in play here lie within the same range when further compared to previous delivery studies of AAS and/or IBU from Fe-CPO-27@IBU (100%, 4 days, phosphate-buffered saline (PBS)), 46 MIL-100(Cr)@IBU (100%, 3 days, simulated body fluid (SBF)), MIL-101(Cr)@IBU (100%, 6 days, SBF), 10 MIL-100(Fe)@AAS (33%, 10 days, PBS; 2%, 7 days, pH 1.2), 35 or Zn 3 (BTC) 2 @IBU (34%, 1 day, PBS), 47 except for the flexible MOFs, in which much longer delivery times were observed: MIL-53(Cr)@IBU (100%, 18 days, SBF) and MIL-53(Fe)@IBU (100%, 20 days, SBF). 48 However, as most of the studies described in the literature were performed under different conditions (e.g., simulated gastric conditions (pH 1.2) or intravenous conditions (e.g., PBS, SBF)), a direct comparison is not possible because it is known that the composition of the media (e.g., ions, proteins) strongly affects the drug release kinetics.…”

Optimized synthesis of nano-scale high quality HKUST-1 under mild conditions and its application in CO2 capture

“…In addition, the size of HKUST-1 particles prepared via these methods is in micron scale and cannot meet some special requirements in catalysis when nano particles are preferred to enable higher mass transfer rate or to achieve higher thermal resistance [14][15] . Because of this, there has been numerous work being carried out on the synthesis of nanoscale MOFs [16][17][18] . However, there is still a need to develop cost-effective techniques for the preparation of nanoscale HKUST-1 MOFs under mild conditions, which are able to produce MOFs with high surface area (>1500 m 2 /g).…”

The novel composite material MOF‐[Mg3(BTC)2]/GO/Fe3O4 and its use in slow‐release ibuprofen

“…Ethanol (96%), n-hexane (99%), Tween 80, and KMnO 4 (99%) were provided by Merck (Darmstadt, Germany). Ibuprofen was obtained from Na-ibuprofen hydrolysis (Supporting Information Figure S1) according to the method by Lestari et al, [13] and Fe 3 O 4 was prepared with the electrochemical method (Supporting Information Figure S2) according to Patimah et al [29] GO was synthesized via the Hummer method (Supporting Information Figure S3) according to Taufantri et al [30] PBS of pH 5.0 and 7.4 were prepared based on a method by Promega. [31] morphology, size, and element analysis were observed using scanning electron microscopy-energy dispersive X-ray spectroscopy (SEM-EDX) with an FEI Inspect S50 (Hillsboro, Oregon, U.S) and transmission electron microscopy (TEM) with a 120-kVJEM-1400 (Massachusetts, U.S).…”