Green biosynthesis of silver nanoparticles produced from marine Streptomyces sp. Al-Dhabi-89 and their potential applications against wound infection and drug resistant clinical pathogens

Al-Dhabi, Naïf Abdullah; Ghilan, Abdul-Kareem Mohammed; Arasu, Mariadhas Valan; Duraipandiyan, Veeramuthu

doi:10.1016/j.jphotobiol.2018.09.012

Cited by 85 publications

(32 citation statements)

References 28 publications

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“…The recorded MICs values of AgNPs in the current study come very close to the values reported previously [18] when AgNPs of an average size of 8.23 nm ± 0.91 nm were tested against MDR uropathogens including E.coli, Klebsiella, P.aeruginosa and Acinetobacter isolates with MIC values of (8, 4, 8 and 16 µg/ml). Higher MIC values of 31.25µg/ml and 62.5µg/ml were reported [19] on using 11-21 nm AgNPs against E.coli and Klebsiella pneumoniae, respectively. An obviously lower MIC value was reported [20] with AgNPs MIC of 1 µg/ml against P.aeruginosa.…”

Section: Discussionmentioning

confidence: 87%

Evaluation of antibacterial activity of silver nanoparticles against multidrug-resistant Gram negative bacilli clinical isolates from Zagazig University Hospitals

Desouky

Shalaby

Gohar

et al. 2020

Microbes and Infectious Diseases

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Background: The growing incidence of multidrug resistant (MDR) bacterial infections has become a public health crisis. This work aims to evaluate the in-vitro activity of silver nanoparticles (AgNPs), alone and in combination with the antimicrobials amikacin and ceftazidime, against MDR Gram-negative bacilli (GNB) isolated from clinical cases in Zagazig University Hospitals. Methods: In a cross sectional study, MDR GNB were isolated from different clinical specimens and were tested to determine the minimal inhibitory concentration (MIC), minimal bactericidal concentration (MBC) and bactericidal activity of AgNPs using broth microdilution method. The effect of combining subMIC levels of AgNPs (MIC/2 and MIC/4) with amikacin and ceftazidime, was also determined by broth microdilution. Results: A total of 63 MDR GNB was obtained during the study period (22 E. coli, 17 Klebsiella, 15 Pseudomonas aeruginosa and 9 Acinetobacter isolates). AgNPs demonstrated a bactericidal effect on all tested isolates with an MBC/MIC ratio of less than 4. When combined with amikacin, a synergistic effect was demonstrated on all tested E.coli and Klebsiella isolates at AgNPs MIC/2 and on 45.4%, 40% and 77.8% of E.coli, P.aeruginosa and Acinetobacter isolates, respectively at MIC/4. In combination with ceftazidime, AgNPs exhibited a synergistic effect on 100% of E. coli and 88.2% Klebsiella at both MIC/2 and MIC/4 and on 40% of P. aeruginosa isolates at AgNPs MIC/4. Conclusions: AgNPs exert a bactericidal activity on MDR GNB as well as a synergistic effect when combined with amikacin and ceftazidime suggesting them as a new weapon in the war against MDR GNB.

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Section: Discussionmentioning

confidence: 87%

Evaluation of antibacterial activity of silver nanoparticles against multidrug-resistant Gram negative bacilli clinical isolates from Zagazig University Hospitals

Desouky

Shalaby

Gohar

et al. 2020

Microbes and Infectious Diseases

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“…Actinobacteria, Gram positive bacteria, are the pioneers among all microbes in term of producing antimicrobial agents in drug discovery programs (Ellaiah et al, 2004, Stackebrandt et al, 1997, Arasu et al, 2013a, Balachandran et al, 2015, Al-Dhabi et al, 2018a, Al-Dhabi et al, 2018b). In nature, the distribution of actinobacteria are very diverse and represent a main source for commercially active molecules (Andrew and Cook Paul, 2003, Valli et al, 2012).…”

Section: Introductionmentioning

confidence: 99%

Chemical profiling of Streptomyces sp. Al-Dhabi-2 recovered from an extreme environment in Saudi Arabia as a novel drug source for medical and industrial applications

Al-Dhabi

Esmail

Duraipandiyan

et al. 2019

Saudi Journal of Biological Sciences

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Filamentous bacterial belonged to Streptomyces species were novel drug source for medical and industrial applications. However, the detailed identification of Streptomyces species from Saudi Arabian extreme environment for the identification novel drug source for medical and industrial applications were rarely studied. The Streptomyces strain Al-Dhabi-2 obtained from the thermophilic region kingdom of Saudi Arabia, exhibited antimicrobial potentials against the pathogenic microorganism were characterized. Biochemical and phylogenetic analysis confirmed that the strain was closely associated to the Streptomyces species. The chromatogram of GC-MS analysis of this ethyl acetate extract (EA) had diverse of chemical compounds namely benzene acetic acid (7.81%), acetic acid, methoxy-, 2-phenylethyl ester (6.01%) were the major compounds. EA of Al-Dhabi-2 showed inhibition zone ranged from 14 to 25 mm at 5 mg/well concentration against the tested microbial pathogens. Results revealed that the significant MIC values were observed against B. cereus, and E. faecalis by (less than 39 μg/ml) and against S. agalactiae with (78 μg/ml). Minimum inhibitory concentrations (MIC) for fungi: were also reported against Cryptococcus neoformans and Trichophyton mentagrophytes by (156 μg/ml), whilst Candida albicans and Aspergillus niger by (312 μg/ml). Results of this study showed that thermophilic actinobacteria could be promise source in the context of searching for unique antimicrobial agents with novel properties.

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“…Infectious diseases are the important cause of death among populations. About 70% of hospital deaths are mainly due to various infectious diseases caused by bacteria, fungi or viruses (Gnanamani et al, 2003, Al-Dhabi et al, 2018). Antibiotic resistance is a significant problematic and also some commercially available antibiotics were seriously associated with hypersensitivity and allergic reactions.…”

Section: Introductionmentioning

confidence: 99%

Identification of phytochemical components from Aerva lanata (Linn.) medicinal plants and its in-vitro inhibitory activity against drug resistant microbial pathogens and antioxidant properties

Al-Ansari

Al-Humaid

Vijayaraghavan

et al. 2019

Saudi Journal of Biological Sciences

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This study aimed to determine the phytochemical components, microbial inhibitory effectiveness and antioxidant properties of Aerva lanata plant extracts. The whole plant showed various medicinal applications in folklore and traditional medicine in various parts of the world. The organic extracts such as ethanol, ethyl acetate, chloroform, acetone, water and methanol were subjected for various phytochemical analysis and confirmed for the existence of flavonoids, glycosides, terpenoids and alkaloid containing components. Alternatively, the extracts were performed for the antibacterial activities against the microbial pathogens and antioxidant properties. Results indicated that, the solvent extracts showed prominent activity against the tested strains. The MIC concentrations of plant were detected from 5 mg/ml to 40 mg/ml. The plant extract was highly effective against E. coli and E. aerogenes and the MIC was 5 mg/ml. In addition, the extracts noted promising antioxidant activities. The antioxidant activities were dose dependent manner. In conclusion, A. lanata extracts showed that significant major phytochemicals and effective antioxidant and anti-microbial properties.

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Green biosynthesis of silver nanoparticles produced from marine Streptomyces sp. Al-Dhabi-89 and their potential applications against wound infection and drug resistant clinical pathogens

Cited by 85 publications

References 28 publications

Evaluation of antibacterial activity of silver nanoparticles against multidrug-resistant Gram negative bacilli clinical isolates from Zagazig University Hospitals

Evaluation of antibacterial activity of silver nanoparticles against multidrug-resistant Gram negative bacilli clinical isolates from Zagazig University Hospitals

Chemical profiling of Streptomyces sp. Al-Dhabi-2 recovered from an extreme environment in Saudi Arabia as a novel drug source for medical and industrial applications

Identification of phytochemical components from Aerva lanata (Linn.) medicinal plants and its in-vitro inhibitory activity against drug resistant microbial pathogens and antioxidant properties

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