Green cardamom mediated phytosynthesis of ZnONPs and validation of its antibacterial and anticancerous potential

Abstract

Different conventional methods for synthesizing zinc oxide nano-particles (ZnONPs) significantly involves physical and chemical routes. But, often these synthesis processes are quite expensive and also involve the profuse use of many hazardous reagents. To overcome these problems, we have employed a convenient single step phytochemical synthesis of ZnONPs by using abundantly available bioresource, green cardamom. Aqueous extract of green cardamom served the purpose of reducing agent in the formation of ZnONPs, as the extract contains a high amount of flavonoids which hold great reducing properties. Various characterization analyses such as XRD, UV-vis, FTIR, SEM has been done to confirm the formation of ZnONPs and their size and shape. Antibacterial activity of the green ZnONPs was identified against Gram-positive as well as Gram-negative bacterial strains. Significant growth inhibition was found against all. The further anti-cancerous potential of synthesized nanoparticles was also studied on hepatocellular cell lines showing its potential to be a trustworthy anti-cancerous agent.

Green Synthesis Method of ZnO Nanoparticles using Extracts of Zingiber officinale and Garlic Bulb (Allium sativum) and Their Synergetic Effect for Antibacterial Activities

“…Green synthesis of ZnO NPs has been carried out by extracting different plants such as Cassia fistula and Melia Azadarch [19], garlic (Allium sativum) [20], Z. officinale (ginger), Aloe vera [21], coffee [22], orange peel extract [23], Cardamom [24], and Lippia adoensis (koseret) [25]. However, the comparison of antimicrobial activities of ZnO synthesized using ginger (Z. officinale), garlic (Allium sativum) extract, and most importantly the antimicrobial activities of ZnO nanoparticles synthesized by the synergetic effect of the mixture of the two extracts were not performed so far to the best of our knowledge.…”

Green Mediated Synthesis of Zinc Oxide Nanoparticles using Tamarind Bark Extract and their Applications in Textile Dye Degradation and Antimicrobial Studies

“…Green synthesis of ZnO nanoparticles has been carried out with the extracts of different parts of the plant such as an orange peel extract [26], tamarind pulp extract [27], ginger (Z. offcinale) [28], garlic (Allium sativum) [29], coffee [30], Aloe vera [31] extract, neem (Azadirachta idica) [32], hibiscus (Hibiscus rosasinensis) extract [33], cardamom [34], Cayratia pedata leaf extract [35], etc. We are the first to describe ZnO nanoparticle production utilizing tamarind bark extract.…”

Comparative evaluation of the antibacterial and cytotoxic activity of green synthesized and commercially available ZnO nanoparticles

“…Excellent antibacterial activity of ZnONPs have also been reported against high temperature and pressure resistant spores apart from its anticancer potential. Electrostatic adsorption of the particles to the bacterial surface and formation of Hydrogen peroxide are considered to be the reason of efficient antibacterial activity of ZnONPs (4). Based on this potent antibacterial efficacy, ZnONPs gained enough advantage in the arena of food and wood preservation, wound dressing, nano-medicines, cosmetics and disinfectant agents.…”