Green chemistry approaches for thiazole containing compounds as a potential scaffold for cancer therapy

Sharma, Diksha; Sharma, Vishal; Sharma, Archana; Goyal, Rajat; Tonk, Rajiv Kumar; Thakur, Vijay Kumar; Sharma, Prabodh Chander

doi:10.1016/j.scp.2021.100496

Cited by 10 publications

(10 citation statements)

References 80 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Cancer society stated that nearly 14.1 million cases of cancer and approximately 8.2 million deaths have been reported, implying that one out of every seven deaths is caused by cancer, which is greater than consolidated tuberculosis, Acquired Immune Deficiency Syndrome (AIDS), and protozoal infections. With this trend, it is expected that by 2030, around 21.6 million new cases of cancer and approximately 13.0 million deaths due to cancer would arrive ( Sharma et al, 2021 ).…”

Section: Introduction: Cancer and Sirna-based Therapymentioning

confidence: 99%

See 1 more Smart Citation

Insights on prospects of nano-siRNA based approaches in treatment of Cancer

Goyal¹,

Chopra

Singh

et al. 2022

Front. Pharmacol.

Self Cite

View full text Add to dashboard Cite

siRNA interference, commonly referred to as gene silence, is a biological mechanism that inhibits gene expression in disorders such as cancer. It may enhance the precision, efficacy, and stability of medicines, especially genetic therapies to some extent. However, obstacles such as the delivery of oligonucleotide drugs to inaccessible areas of the body and the prevalence of severe side effects must be overcome. To maximize their potential, it is thus essential to optimize their distribution to target locations and limit their toxicity to healthy cells. The action of siRNA may be harnessed to delete a similar segment of mRNA that encodes a protein that causes sickness. The absence of an efficient delivery mechanism that shields siRNA from nuclease degradation, delivers it to cancer cells and releases it into the cytoplasm of specific cancer cells without causing side effects is currently the greatest obstacle to the practical implementation of siRNA therapy. This article focuses on combinations of siRNA with chemotherapeutic drug delivery systems for the treatment of cancer and gives an overview of several nanocarrier formulations in both research and clinical applications.

show abstract

Section: Introduction: Cancer and Sirna-based Therapymentioning

confidence: 99%

“…expected that by 2030, around 21.6 million new cases of cancer and approximately 13.0 million deaths due to cancer would arrive (Sharma et al, 2021).…”

mentioning

confidence: 99%

Insights on prospects of nano-siRNA based approaches in treatment of Cancer

Goyal¹,

Chopra

Singh

et al. 2022

Front. Pharmacol.

Self Cite

View full text Add to dashboard Cite

show abstract

“…5 Thus, a number of strategies have been developed for the synthesis of thiazole derivatives that are selectively substituted. [6][7][8] Particularly, trifluoromethylated thiazoles have gained more attention in recent years. [9][10][11][12][13][14][15][16][17][18][19] This is probably because the biological activity of thiazoles can be modified by the incorporation of trifluoromethyl into their structure.…”

Section: Introductionmentioning

confidence: 99%

“…5 Thus, a number of strategies have been developed for the synthesis of thiazole derivatives that are selectively substituted. 6–8…”

Section: Introductionmentioning

confidence: 99%

Synthesis of 2-trifluoromethyl thiazoles via [3 + 2] cycloaddition of pyridinium 1,4-zwitterionic thiolates with CF₃CN

Yao

Lin

et al. 2022

Org. Biomol. Chem.

View full text Add to dashboard Cite

show abstract

“…Cancer is the foremost difficulty of the century, and it has a tremendous impact on the social, mental, and physical lives of human beings [1][2][3]. There is almost a 5% increase in cancer occurrence in developing countries, but this rate is around 1-2% in developed countries [1,4]. Among various types, breast cancer is the most prevalent and the second most deadly type of cancer.…”

Section: Introductionmentioning

confidence: 99%

Quantum Dots: Synthesis, Antibody Conjugation, and HER2-Receptor Targeting for Breast Cancer Therapy

Fatima

Rahdar

Sargazi

et al. 2021

JFB

Self Cite

View full text Add to dashboard Cite

Breast cancer is becoming one of the main lethal carcinomas in the recent era, and its occurrence rate is increasing day by day. There are different breast cancer biomarkers, and their overexpression takes place in the metastasis of cancer cells. The most prevalent breast cancer biomarker is the human epidermal growth factor receptor2 (HER2). As this biomarker is overexpressed in malignant breast tissues, it has become the main focus in targeted therapies to fight breast cancer. There is a cascade of mechanisms involved in metastasis and cell proliferation in cancer cells. Nanotechnology has become extremely advanced in targeting and imaging cancerous cells. Quantum dots (QDs) are semiconductor NPs, and they are used for bioimaging, biolabeling, and biosensing. They are synthesized by different approaches such as top-down, bottom-up, and synthetic methods. Fully human monoclonal antibodies synthesized using transgenic mice having human immunoglobulin are used to target malignant cells. For the HER2 receptor, herceptin® (trastuzumab) is the most specific antibody (Ab), and it is conjugated with QDs by using different types of coupling mechanisms. This quantum dot monoclonal antibody (QD-mAb) conjugate is localized by injecting it into the blood vessel. After the injection, it goes through a series of steps to reach the intracellular space, and bioimaging of specifically the HER2 receptor occurs, where apoptosis of the cancer cells takes place either by the liberation of Ab or the free radicals.

show abstract

Green chemistry approaches for thiazole containing compounds as a potential scaffold for cancer therapy

Cited by 10 publications

References 80 publications

Insights on prospects of nano-siRNA based approaches in treatment of Cancer

Insights on prospects of nano-siRNA based approaches in treatment of Cancer

Synthesis of 2-trifluoromethyl thiazoles via [3 + 2] cycloaddition of pyridinium 1,4-zwitterionic thiolates with CF₃CN

Quantum Dots: Synthesis, Antibody Conjugation, and HER2-Receptor Targeting for Breast Cancer Therapy

Contact Info

Product

Resources

About

Green chemistry approaches for thiazole containing compounds as a potential scaffold for cancer therapy

Cited by 10 publications

References 80 publications

Insights on prospects of nano-siRNA based approaches in treatment of Cancer

Insights on prospects of nano-siRNA based approaches in treatment of Cancer

Synthesis of 2-trifluoromethyl thiazoles via [3 + 2] cycloaddition of pyridinium 1,4-zwitterionic thiolates with CF3CN

Quantum Dots: Synthesis, Antibody Conjugation, and HER2-Receptor Targeting for Breast Cancer Therapy

Contact Info

Product

Resources

About

Synthesis of 2-trifluoromethyl thiazoles via [3 + 2] cycloaddition of pyridinium 1,4-zwitterionic thiolates with CF₃CN