Green Extraction of Cork Bioactive Compounds Using Natural Deep Eutectic Mixtures

Freitas, David S.; Rocha, Diana; Castro, Tarsila G.; Noro, Jennifer; Castro, Vânia I. B.; Teixeira, Marta A.; Reis, Rui L.; Cavaco-Paulo, Artur; Silva, Carla

doi:10.1021/acssuschemeng.2c01422

Cited by 33 publications

(29 citation statements)

References 61 publications

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“…The NADES used (Table 1) in this study were chosen based on their composition; the three NADES are based on natural compounds that have demonstrated good extraction abilities in previous studies [14].…”

Section: Nades Developmentmentioning

confidence: 99%

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NADES-Based Cork Extractives as Green Ingredients for Cosmetics and Textiles

et al. 2023

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The demand for products based on natural ingredients is increasing among cosmetic and textile consumers. Cork extracts contain components of interest with special properties, including antioxidant, anti-inflammatory, and antibacterial activities, that might improve the effectiveness of cosmetic formulations currently on the market and may impart new characteristics to textiles. The main goal of this work was to investigate the effect of the incorporation of three cork extracts into two commercial cosmetic formulations (formulation A and B) and evaluate their role as textile dyeing agents. The extracts (E1, E2, and E3) were obtained from cork powder using natural deep eutectic solvents (NADES) (E1-NADES 1: lactic acid:glycerol, E2-NADES 2: lactic acid:glycine, and E3-NADES 3: lactic acid:sodium citrate) and applied in combination with the solvent. The impact of the extracts on the cosmetic formulations’ properties was evaluated in terms of pH, viscosity, antioxidant activity, transdermal permeation capacity, cytotoxicity, and organoleptic characteristics (odor, color, and appearance). The results demonstrated that the cork extracts improved the antioxidant performance of the formulations (90% reduction in DPPH (1,1-difenil-2-picril-hidrazil)). Moreover, low concentrations (5 mg/mL and 10 mg/mL) of extract did not present a cytotoxic effect on keratinocytes. Cotton fabrics were efficiently dyed with the NADES-based cork extracts which conferred to these substrates antioxidant (78% in DPPH reduction) and antibacterial abilities (inhibition halos: 12–15 mm). The application of cork extracts as ingredients in cosmetics or as dyeing/coloration agents for textile coloration is revealed to be a promising and green route to replace harmful ingredients normally used in industry.

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Section: Nades Developmentmentioning

confidence: 99%

“…Freitas et al produced cork extracts using natural deep eutectic mixtures to design environmentally benign processes to eliminate or reduce the use of toxic chemicals. The results revealed higher extraction yields when using NADES instead of harsh solvents such as dioxane [14].…”

Section: Introductionmentioning

confidence: 99%

NADES-Based Cork Extractives as Green Ingredients for Cosmetics and Textiles

et al. 2023

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“…According to different types of HBDs, the viscosity of ChCl-based NADES and betaine (Bet)-based NADES was increased as follows: alcohols < organic acids and sugar. But NADES containing LA often have a relatively low viscosity ( Freitas et al, 2022 ).…”

Section: Classification Of Nadesmentioning

confidence: 99%

Applications for natural deep eutectic solvents in Chinese herbal medicines

Rao

et al. 2023

Front. Pharmacol.

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Chinese herbal medicines (CHMs), with a wide range of bioactive components, are considered to be an important source for new drug discovery. However, the process to isolate and obtain those bioactive components to develop new drugs always consumes a large amount of organic solvents with high toxicity and non-biodegradability. Natural deep eutectic solvents (NADES), a new type of green and designable solvents composed of primary plant-based metabolites, have been used as eco-friendly substitutes for traditional organic solvents in various fields. Due to the advantages of easy preparation, low production cost, low toxicity, and eco-friendliness, NADES have been also applied as extraction solvents, media, and drug delivery agents in CHMs in recent years. Besides, the special properties of NADES have been contributed to elucidating the traditional processing (also named Paozhi in Chinese) theory of CHMs, especially processing with honey. In this paper, the development process, preparation, classification, and applications for NADES in CHMs have been reviewed. Prospects in the future applications and challenges have been discussed to better understand the possibilities of the new solvents in the drug development and other uses of CHMs.

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“…In a similar vein, the work described by the Freitas group [ 97 ] uses natural deep eutectic solvents (NADES) with the purpose of eliminating or reducing the use of toxic chemicals. They used different natural compounds, such as lactic acid and glycerol.…”

Section: Sustainabilitymentioning

confidence: 99%

“…On the other hand, more basic eutectic mixtures extracted more quantities of low molecular weight polar compounds. This research, along with the associated nontoxicity, low cost, and ease of preparation, establishes NADES as a green approach to extracting high-added-value compounds from cork [ 97 ].…”

Section: Sustainabilitymentioning

confidence: 99%

Cork, a Natural Choice to Wine?

Azevedo

Lopes

Mateus

et al. 2022

Foods

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This review presents the most recent data on the state-of-the-art of the main compounds present in cork, their interaction with wine, and the impact that natural stoppers may have on wines’ physical-chemical and sensory properties. According to the recent scientific literature, the chemical composition of cork and the scientific relevance of the compounds extract from cork to wine over time are reviewed. Furthermore, the effect of cork compounds transfer into wines during post-bottling is also discussed, as well as their impact on the organoleptic (colour and taste) of wines. This knowledge is essential for the decision-making process undertaken by wine producers to select the stopper most suitable for their wines. In addition, sustainability is also a topic addressed since it is a natural product that generates some waste as well as the way in which this industry is adapting to the closure of the waste cycle.

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Green Extraction of Cork Bioactive Compounds Using Natural Deep Eutectic Mixtures

Cited by 33 publications

References 61 publications

NADES-Based Cork Extractives as Green Ingredients for Cosmetics and Textiles

NADES-Based Cork Extractives as Green Ingredients for Cosmetics and Textiles

Applications for natural deep eutectic solvents in Chinese herbal medicines

Cork, a Natural Choice to Wine?

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