Green extraction of grape skin phenolics by using deep eutectic solvents

Bubalo, Marina Cvjetko; Ćurko, Natka; Tomašević, Marina; Ganić, Karin Kovačević; Redovniković, Ivana Radojčić

doi:10.1016/j.foodchem.2016.01.040

Cited by 448 publications

(146 citation statements)

References 24 publications

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“…The apparent advantage of this approach is the enhanced substrate solubility by DES. Such a property has been successfully applied in the extraction of the natural product [e.g., flavonoid (Zhao et al 2015) and grape skin phenolics (Cvjetko Bubalo et al 2016)]. This case is beneficial for the modification of many natural products, which have good solubility in DES.…”

Section: The Application Of Dess In Biocatalysismentioning

confidence: 99%

Recent progress on deep eutectic solvents in biocatalysis

Zheng

Zong

et al. 2017

Bioresour. Bioprocess.

297

161

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Deep eutectic solvents (DESs) are eutectic mixtures of salts and hydrogen bond donors with melting points low enough to be used as solvents. DESs have proved to be a good alternative to traditional organic solvents and ionic liquids (ILs) in many biocatalytic processes. Apart from the benign characteristics similar to those of ILs (e.g., low volatility, low inflammability and low melting point), DESs have their unique merits of easy preparation and low cost owing to their renewable and available raw materials. To better apply such solvents in green and sustainable chemistry, this review firstly describes some basic properties, mainly the toxicity and biodegradability of DESs. Secondly, it presents several valuable applications of DES as solvent/co-solvent in biocatalytic reactions, such as lipase-catalyzed transesterification and ester hydrolysis reactions. The roles, serving as extractive reagent for an enzymatic product and pretreatment solvent of enzymatic biomass hydrolysis, are also discussed. Further understanding how DESs affect biocatalytic reaction will facilitate the design of novel solvents and contribute to the discovery of new reactions in these solvents.

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Section: The Application Of Dess In Biocatalysismentioning

confidence: 99%

Recent progress on deep eutectic solvents in biocatalysis

Zheng

Zong

et al. 2017

Bioresour. Bioprocess.

297

161

View full text Add to dashboard Cite

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“…Among the choline chloride‐based DES combinations, hydrogen bond donors including lactic acid and glycerol obtained better extraction yields of the four target compounds. Compared with 50% aqueous ethanol, DES‐11, DES‐12 and DES‐13 (choline chloride/glycerol, molar ratio of 1:4, 1:5 and 1:6, respectively) exhibited more than 83% extraction efficiency of epimedin A and epimedin C. Additionally, DES‐13 showed higher yields than DES‐11 and DES‐12, which probably attributed to the higher polarity of glycerol and hydrogen bonding ability produced by glycerol and choline chloride . Accordingly, high polar DES combinations of choline chloride and lactic acid showed obvious superiority.…”

Section: Resultsmentioning

confidence: 96%

Efficient extraction and determination of prenylflavonol glycosides in Epimedium pubescens Maxim. using deep eutectic solvents

Wang

Peng

Zhao

et al. 2019

Phytochemical Analysis

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Introduction The Epimedium herb, Yinyanghuo in Chinese, is a famous Chinese herbal medicine. In this study, an efficient extraction method was developed for the extraction of major bioactive constituent epimedin A, epimedin B, epimedin C and icariin from E. pubescens Maxim. using deep eutectic solvents (DESs). Methodology A series of choline chloride‐based DESs were synthesised for the extraction of four target compounds. DES composed of lactic acid and choline chloride with the ratio of 2:1 was selected as the most promising. Three vital factors affecting the extraction yields including water content, volume of DES aqueous solution and extraction time were optimised systematically by Box–Behnken experimental design in combination with response surface methodology. A high‐performance liquid chromatography ultraviolet (HPLC‐UV) method was developed for the sensitive and accurate quantification. Results The optimal extraction conditions were obtained as follows: water content of 17.5% (v/v), volume of DES aqueous solution 3.14 ml, and extraction time of 21 min. Under the optimal extraction conditions, the developed DES method could supply almost the same extraction yield as 50% ethanol, which were 98%, 99%, 97%, 96% for epimedin A, epimedin B, epimedin C and icariin, respectively. Conclusion The present study exhibited high efficiency in extraction of prenylflavonol glycosides in E. pubescens Maxim. Thus, DESs could be used as an alternative for efficient extraction and quantification of biologically active components from natural medical plants.

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“…They have been used as extraction solvents for a variety of analytes . Moreover, analytes with phenolic hydroxyl groups can be dissolved in DESs better than in other solvents because they can easily accept and donate electrons and protons through hydrogen bonding …”

Section: Introductionmentioning

confidence: 99%

Hyphenated dispersive solid‐ and liquid‐phase microextraction technique based on a hydrophobic deep eutectic solvent: application for trace analysis of pesticides in fruit juices

et al. 2020

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BACKGROUND Pesticides are extensively used worldwide to control plant pathogens and prevent agricultural product damage. However, they can pollute the environment and endanger human health. So far, a variety of sample preparation methods have been developed for the analysis of pesticide residues. RESULTS A hyphenated solid–liquid microextraction method based on a new adsorbent of magnetic graphene oxide functionalized by (3‐glycidyloxypropyl)trimethoxysilane and a deep eutectic solvent (choline chloride/4‐chlorophenol (1:2)) was developed for extraction/preconcentration of trace levels of pesticides. The sorbent was characterized using scanning electron microscopy, Fourier transform infrared spectroscopy, and vibrating sample magnetometry. In‐syringe magnetic dispersive solid‐phase extraction in tandem with dispersive liquid–liquid microextraction followed by gas chromatography was applied for the analysis of the selected pesticides. The main parameters governing sample preparation efficiency, including adsorbent dosage, desorption conditions, pH, extraction time, deep eutectic solvent volume, and salt concentration, were investigated. The linear ranges were 0.024–500 μg L−1 with 0.9971–0.9999 linearity factor (R2). The limits of detection and quantification were 0.006–0.038 and 0.024–0.126 μg L−1, respectively. The relative standard deviations were 0.5–4.2% for intra‐day analysis and 2.7–4.6% for inter‐day analysis. Enrichment factors were in the range 210–540. CONCLUSIONS The method was successfully applied for the determination of malathion, heptachlor epoxide, endrin, dichlorodiphenyltrichloroethane, azinphos ethyl, cypermethrin, and deltamethrin in fruit juice samples (apple, pineapple, cherry, peach, and red and green grape juices) and the recoveries were within the range 71–115%. © 2020 Society of Chemical Industry

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Green extraction of grape skin phenolics by using deep eutectic solvents

Cited by 448 publications

References 24 publications

Recent progress on deep eutectic solvents in biocatalysis

Recent progress on deep eutectic solvents in biocatalysis

Efficient extraction and determination of prenylflavonol glycosides in Epimedium pubescens Maxim. using deep eutectic solvents

Hyphenated dispersive solid‐ and liquid‐phase microextraction technique based on a hydrophobic deep eutectic solvent: application for trace analysis of pesticides in fruit juices

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