Green hemostatic sponge-like scaffold composed of soy protein and chitin for the treatment of epistaxis

Jimenez-Martin, Jon; Heras, Kevin Las; Etxabide, Alaitz; Uranga, Jone; Caba, Koro de la; Guerrero, Pedro; Igartúa, Manoli; Santos‐Vizcaíno, Edorta; Hernández, Rosa María

doi:10.1016/j.mtbio.2022.100273

Cited by 8 publications

(2 citation statements)

References 96 publications

(105 reference statements)

Supporting

Mentioning

Contrasting

Order By: Relevance

“…[ 152 ] What's more, studies have utilized natural by‐products from the food industry, such as soy protein and beta‐chitin, to create spongy scaffolds for treating rhinorrhea. [ 153 ] This not only stops bleeding but also utilizes natural ingredients in the field of biomedicine.…”

Section: Applications Of the Hemostasis Hydrogelsmentioning

confidence: 99%

Preparation and Application of Hemostatic Hydrogels

Zhou,

Lin,

Wang

et al. 2023

Small

View full text Add to dashboard Cite

Hemorrhage remains a critical challenge in various medical settings, necessitating the development of advanced hemostatic materials. Hemostatic hydrogels have emerged as promising solutions to address uncontrolled bleeding due to their unique properties, including biocompatibility, tunable physical characteristics, and exceptional hemostatic capabilities. In this review, a comprehensive overview of the preparation and biomedical applications of hemostatic hydrogels is provided. Particularly, hemostatic hydrogels with various materials and forms are introduced. Additionally, the applications of hemostatic hydrogels in trauma management, surgical procedures, wound care, etc. are summarized. Finally, the limitations and future prospects of hemostatic hydrogels are discussed and evaluated. This review aims to highlight the biomedical applications of hydrogels in hemorrhage management and offer insights into the development of clinically relevant hemostatic materials.

show abstract

Section: Applications Of the Hemostasis Hydrogelsmentioning

confidence: 99%

Preparation and Application of Hemostatic Hydrogels

Zhou,

Lin,

Wang

et al. 2023

Small

View full text Add to dashboard Cite

show abstract

“…It has been reported that 50% of deaths in the army are due to improper or inadequate treatment . Unfortunately, traditional methods of hemostasis, such as suture and compression with gauze, are suitable for minor injuries and cannot be used to treat major bleeding, especially for cardiovascular, hepatic, gastrointestinal, and orthopedic treatments. , They may lead to hemorrhagic shock or death once performed undeservedly. , Nowadays, a wide variety of biological sources and polysaccharide-based materials have been investigated as topical hemostatic agents, such as chitosan, cellulose, gelatin, and so on (Surgicel, Celox, HemConBandage). − Besides, polyethylene glycol and catechol monomers with antibacterial and adhesive properties are also effective hemostatic materials (Wound stat, Combat Gauze). − In addition, some inorganic materials, such as silica or silica–aluminate and mineral zeolite are also used as hemostatic materials due to unique structure (Coseal). − However, the applications of hemostatic agents are limited by biological safety, hemostatic effect, and high cost. For example, synthetic derived materials mainly have potential problems such as cytotoxicity and nonbiodegradability; , biologically derived hemostatic agents are expensive, have a short shelf life and a potential risk of viral contamination; and inorganic materials often cause thermal damage and inflammation in clinical application. , Additionally, another key challenge that has been overlooked is the vulnerability of wounds to infection during hemostasis.…”

Section: Introductionmentioning

confidence: 99%

Fabricating Oxidized Cellulose Sponge for Hemorrhage Control and Wound Healing

Bai

et al. 2023

ACS Biomater. Sci. Eng.

View full text Add to dashboard Cite

Uncontrolled hemorrhage and infection are the main reasons for many trauma-related deaths in both clinic and battlefield. However, most hemostatic materials have various defects and side effects, such as low hemostatic efficiency, poor biocompatibility, weak degradation ability, and lack of antimicrobial properties. Herein, an oxidized cellulose (OC) sponge with antibacterial properties and biosafety was fabricated for hemorrhage control and wound healing. The as-prepared OC sponges were prone to water triggered expansion and superabsorbent capacity, which could facilitate blood component concentration effectively. Importantly, they had significant biodegradability with little irritation to the skin. This hemostat could also reduce the plasma clotting time to 53.54% in vitro and demonstrated less blood loss than commercially available hemostatic agents (GS) in a mouse model of bleeding from liver defects. Furthermore, the biocompatibility antimicrobial properties and possible hemostatic mechanism of the OC sponge were also systematically evaluated. Importantly, the potential wound healing applications have also been demonstrated. Therefore, the materials have broad clinical application prospects.

show abstract