Green innovative fluorescence approach for the feasible and reliable assay of thiol-containing drugs; captopril as a model

Abstract

The excitation and emission spectra of the reagent blank and the reaction product of captopril (200 ng mL−1) with o-phthaldehyde/heptaminol.

Developing Metal Complexes for Captopril Quantification in Tablets Using Potentiometric and Conductometric Methods

“…It can be seen that CAP can be detected at 0.64 mg/mL (SD = 0.20, R = 0.9992 ( n = 5)). The calculated correlation coefficients are quite similar to those obtained earlier using various approaches for determining CAP like chromatography, − fluorometry, − UV–visible spectroscopy, , chemiluminescence, voltammetry, − potentiometry, − and conductometry − methods. Using the proposed methods, CAP was determined successfully over a concentration range from 0.83 to 13.04 mg/mL (Figure ).…”

“…Captopril (CAP), also known chemically as [2S]-N-[3-mercapto-2-methylpropionyl)-L-proline, is a broadly utilized drug for the treatment of high blood pressure, diabetic nephropathy, congestive heart seizure, and the preservation of kidney damage. , In order to investigate the presence of CAP in pharmaceuticals, numerous analytical procedures have been postulated. CAP was determined using chromatography, − fluorometry, − UV–visible spectroscopy, , chemiluminescence, and voltammetric techniques. − Although these analytical strategies are highly sensitive and accurate, they are costly, time-consuming, and require complex procedures for sample preparation and analysis protocols.…”

An eco‐friendly matrix‐augmented fluorescence spectroscopic approach for the analysis of mitoxantrone, an oncogenic therapy; application to the dosage form and biological matrices

“…To minimize sample reabsorption effects, the absorbance values of all produced solutions were kept below 0.1. [ 39,40 ]…”

“…To minimize sample reabsorption effects, the absorbance values of all produced solutions were kept below 0.1. [39,40] 3.6 | Rating of the method's greenness Chemical and pharmaceutical analyzers bear a significant portion of safeguarding the environment and individuals from harmful diluting media and organic waste. Green analytical chemistry is constantly evolving and must be taken into account regularly.…”

A green fluorescence turn-off system for meclofenoxate determination by Cilefa Pink B dye

“…As the analysis becomes more environmentally friendly, the rate will rise (to a greater value). 45,46 Energy consumption per sample was less than 0.1 kW h because no extraction or heating was required. Using an aqueous medium to carry out the method resulted in a high ecoscale score (95) (Table 7).…”