Green methods for the preparation of MgO nanomaterials and their drug delivery, anti-cancer and anti-bacterial potentials: A review

Nejati, Majed; Rostami, Mohammad; Mirzaei, Hamed; Rahimi-Nasrabadi, Mahdi; Vosoghi, Mohamad; Sobhani‐Nasab, Ali; Ganjali, Mohammad Reza

doi:10.1016/j.inoche.2021.109107

Cited by 53 publications

(22 citation statements)

References 133 publications

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“…[59] In our findings, the hydrogen peroxide formed in DNA damage that increases with increasing concentrations of PdCu@f-MWCNT NPs has an effect on easily diffusing and forming OH radical via Fenton reaction. [58] Increased DNA damage ultimately leads to planned cell death, which is confirmed by the caspase-3 level in our research findings. By interacting directly with DNA, PdNPs elicit genotoxic effects indirectly through apoptotic responses and oxidative stress.…”

Section: Discussionsupporting

confidence: 82%

“…[57] As the NPs enter the mitochondria, it disrupts the electron transduction of the NPs in the inner membrane, causing their accumulation in the membrane and ultimately the formation of ROS. Increased ROS induces DNA double-strand breaks or DNA point mutations [58] and may affect apoptosis, lipid peroxidation, redox imbalance in the cell, and some antioxidant responses. [59] In our findings, the hydrogen peroxide formed in DNA damage that increases with increasing concentrations of PdCu@f-MWCNT NPs has an effect on easily diffusing and forming OH radical via Fenton reaction.…”

Section: Discussionmentioning

confidence: 99%

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May PdCu@f‐MWCNT NPs be an ecotoxicologic risk?

Alak

Yeltekin

Köktürk

et al. 2023

Applied Organom Chemis

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The mechanisms of various metal nanoparticles (NPs) are still a matter of debate in aquatic toxicology. In order to close this gap, the number of studies on this subject is increasing. The aims of this study are to explore the interactions of PdCu@f-MWCNT NPs with zebrafish and get to know if it has an ecotoxicological risk. In this study, we synthesized, characterized PdCu@f-MWCNT NPs, and investigated its ecotoxicological effects. The chemical and morphological structures of PdCu@f-MWCNT nanomaterials were elucidated with advanced analysis techniques such as scanning electron microscope (SEM), X-ray spectrophotometer (EDX), transmission electron microscope (TEM), and X-ray diffraction (XRD) analyses. The ecotoxicological risks were investigated by conducting biochemical analyses and malformation defects in zebrafish. The results were obtained using multiple marker applications including oxidative stress parameters, proinflammatory cytokine expressions, DNA damage, and apoptosis markers. The obtained findings showed embryonic development, survival rate, and incidence of malformation increasing in parallel with the dose increase in zebrafish exposed to PdCu@f-MWCNT NPs at 10-1000 μg/L levels. Despite the observed decreases in antioxidant enzyme activities, GSH level, AChE activity, and NRF-2 level, inductions in malondialdehyde (MDA) level, IL-6, TNF-α, NF-kB, DNA damage, and apoptosis levels were observed with increasing dose. Considering these findings, it has been determined that there are toxic effects in zebrafish at all levels above the concentration that we examine as a safe dose (10 μg/L). The effects of all studied concentrations of this NP above the safe dosage, especially on oxidative stress, malformation, and immune system, were found to be quite significant. The more widespread use of nanotechnology in the future will mean more contact of aquatic organisms with NPs. As a result, it is clearly seen that these organisms, which form the important link of the food chain, and the aquatic environment are living at risk conditions.

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Section: Discussionsupporting

confidence: 82%

Section: Discussionmentioning

confidence: 99%

May PdCu@f‐MWCNT NPs be an ecotoxicologic risk?

Alak

Yeltekin

Köktürk

et al. 2023

Applied Organom Chemis

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“…Reduction of metal ions and the stability of their complexes during the nucleation and growth phases, leads to the formation of metal oxide nanoparticles. Extracts of seeds, flowers, leaves, and green plants, are known to contain high quantities of proteins, amino acids, polyphenols, and reducing sugars (Nejati et al, 2022). These materials can act as reduction and capping agents (Besbes et al, 2004;Xie et al, 2007b;Khan et al, 2012;Hussain et al, 2014).…”

Section: Preparation Of Fe Nanoparticles and Its Biometallic Through ...mentioning

confidence: 99%

Utility of Biogenic Iron and Its Bimetallic Nanocomposites for Biomedical Applications: A Review

et al. 2022

Self Cite

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Nanotechnology mainly deals with the production and application of compounds with dimensions in nanoscale. Given their dimensions, these materials have considerable surface/volume ratios, and hence, specific characteristics. Nowadays, environmentally friendly procedures are being proposed for fabrication of Fe nanoparticles because a large amount of poisonous chemicals and unfavorable conditions are needed to prepare them. This work includes an inclusive overview on the economical and green procedures for the preparation of such nanoparticles (flower, fruits, tea, carbohydrates, and leaves). Pure and bimetallic iron nanoparticles, for instance, offer a high bandwidth and excitation binding energy and are applicable in different areas ranging from antibacterial, anticancer, and bioimaging agents to drug delivery systems. Preparation of nano-sized particles, such as those of Fe, requires the application of high quantities of toxic materials and harsh conditions, and naturally, there is a tendency to develop more facile and even green pathways (Sultana, Journal of Materials Science & Technology, 2013, 29, 795–800; Bushra et al., Journal of hazardous materials, 2014, 264, 481–489; Khan et al., Ind. Eng. Chem. Res., 2015, 54, 76–82). This article tends to provide an overview on the reports describing green and biological methods for the synthesis of Fe nanoparticles. The present review mainly highlights selenium nanoparticles in the biomedical domain. Specifically, this review will present detailed information on drug delivery, bioimaging, antibacterial, and anticancer activity. It will also focus on procedures for their green synthesis methods and properties that make them potential candidates for various biomedical applications. Finally, we provide a detailed future outlook.

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“…Various studies are currently being conducted on zinc oxide nanoparticles (ZnONPs) and magnesium oxide nanoparticles (MgONPs). In addition, the application of both metal oxides in a variety of sectors including immunomodulatory agents [15,16], bactericidal agents [17,18], catalysis [19,20], tissue imaging [21,22], sensors [23,24], food packaging [25,26], and chemotherapeutics [27,28] has received more attention. In sensor construction, the thickness of the coating layer and chemical contents with respect to the loading ceria were examined using various microscopic and spectroscopic approaches including scanning electron microscopy (SEM) and X-ray photoelectron spectroscopy (XPS) [29,30].…”

Section: Introductionmentioning

confidence: 99%

Atropine-Phosphotungestate Polymeric-Based Metal Oxide Nanoparticles for Potentiometric Detection in Pharmaceutical Dosage Forms

et al. 2022

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The new research presents highly conductive polymeric membranes with a large surface area to volume ratio of metal oxide nanoparticles that were used to determine atropine sulfate (AT) in commercial dosage forms. In sensing and biosensing applications, the nanomaterials zinc oxide (ZnONPs) and magnesium oxide (MgONPs) were employed as boosting potential electroactive materials. The electroactive atropine phosphotungstate (AT-PT) was created by combining atropine sulfate and phosphotungstic acid (PTA) and mixing it with polymeric polyvinyl chloride (PVC) with the plasticizer o-nitrophenyl octyl ether (o-NPOE). The modified sensors AT-PT-ZnONPs or AT-PT-MgONPs showed excellent selectivity and sensitivity for the measurements of atropine with a linear concentration range of 6.0 × 10−8 − 1.0 × 10−3 and 8.0 × 10−8 − 1.0 × 10−3 mol L−1 with regression equations of E(mV) = (56 ± 0.5) log [AT] − 294 and E(mV) = (54 ± 0.5) log [AT] − 422 for AT-PT-NPs or AT-PT-MgONPs sensors, respectively. The AT-PT coated wire sensor, on the other hand, showed a Nernstian response at 4.0 × 10−6 − 1.0 × 10−3 mol L−1 and a regression equation E(mV) = (52.1 ± 0.2) log [AT] + 198. The methodology-recommended guidelines were used to validate the suggested modified potentiometric systems against various criteria.

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Green methods for the preparation of MgO nanomaterials and their drug delivery, anti-cancer and anti-bacterial potentials: A review

Cited by 53 publications

References 133 publications

May PdCu@f‐MWCNT NPs be an ecotoxicologic risk?

May PdCu@f‐MWCNT NPs be an ecotoxicologic risk?

Utility of Biogenic Iron and Its Bimetallic Nanocomposites for Biomedical Applications: A Review

Atropine-Phosphotungestate Polymeric-Based Metal Oxide Nanoparticles for Potentiometric Detection in Pharmaceutical Dosage Forms

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