Green Nanotechnology as an innovative drug delivery approach for Typha capensis and Naringenin—New class of phytochemical embedded biocompatible gold nanoparticles in prostate cancer therapy

Pearce, Keenau; Thipe, Velaphi C.; Henkel, Ralf; Katti, Kattesh V.

doi:10.1016/j.jddst.2022.104100

Cited by 10 publications

(2 citation statements)

References 44 publications

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“…TM3 and TM4 cell viability was examined using the 3‐(4,5‐dimethylthiazol‐2‐yl‐2,5‐diphenyl) tetrazolium bromide (MTT) (Sigma‐Aldrich) cell proliferation assay after 24 h of culture, as previously described. [ 32 ] Briefly, in a 96‐well plate, 100 µL of complete culture medium was used to seed 2.5 × 10 3 cells per well for 24 h. The cells were then exposed to testosterone at 0.1, 1, 10, and 20 nM and ATZ at 232 µM for 24 h. The medium was removed and 10 µL of MTT was added to the cells. Thereafter, 100 µL of DMSO was added to dissolve the formazan crystals after the removal of the MTT solution.…”

Section: Methodsmentioning

confidence: 99%

Testosterone restores TM3 and TM4 cell viability, reduces reactive oxygen species generation, and protects against atrazine‐induced stereological changes in rat testes

Mgbudom‐Okah,

Abarikwu,

Wegwu

et al. 2023

J Biochem & Molecular Tox

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In this study, we performed the stereological examination of rat testes and evaluated the protective effect of testosterone against atrazine (ATZ) toxicity in TM3 Leydig and TM4 Sertoli cells. Testosterone intake in rats increased the volumetric density of the seminiferous tubules; tubular diameter; germinal epithelial height; number of spermatogonia, primary and secondary spermatocytes, round spermatids, Sertoli cells, and Leydig cells; and Johnsen scores compared with the values after ATZ treatment (p < 0.05). Furthermore, testosterone increased the viability of TM3 cells and reduced reactive oxygen species (ROS) generation in TM4 cells compared to the ATZ‐treated group. In conclusion, exogenous testosterone intake maintains testicular morphometry and spermatogenesis in rats, and minimizes cell death and ROS generation in testicular cell lines exposed to ATZ. However, TM4 cells are more responsive to testosterone‐mediated regulation of ROS generation induced by ATZ than TM3 cells.

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Section: Methodsmentioning

confidence: 99%

Testosterone restores TM3 and TM4 cell viability, reduces reactive oxygen species generation, and protects against atrazine‐induced stereological changes in rat testes

Mgbudom‐Okah,

Abarikwu,

Wegwu

et al. 2023

J Biochem & Molecular Tox

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show abstract

“…The majority of the biologically active components of extracts, such as tannins, terpenoids, and flavonoids, are highly water insoluble, have large molecular sizes, and exhibit poor absorption, resulting in loss of bioavailability and efficacy [115]. Several studies have shown that herbal remedies have good activity in assays in vitro, which are not reproducible in investigations in vivo [116,117]. Quercetin is a promising candidate for the management of various diseases.…”

Section: Nanotechnology and Quercetin Delivery Systemsmentioning

confidence: 99%

Unveiling the Potential of Quercetin: Chemistry, Health Benefits, Toxicity, and Cutting-Edge Advances

A. Ghareeb,

Z. Zayan,

H. Shari

et al. 2024

Quercetin - Effects on Human Health [Working Title]

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Quercetin, a naturally occurring flavonoid, has gained significant attention in recent years due to its potential health benefits and versatile applications. This book chapter explores the chemistry of quercetin, shedding light on its molecular structure, biosynthesis, and extraction methods. The chapter delves into the extensive research on the health effects of quercetin, highlighting its antioxidant, anti-inflammatory, anticancer, neuroprotective, and cardioprotective properties. Moreover, the potential risks and toxicity associated with quercetin consumption are thoroughly examined, emphasizing the importance of proper dosage and potential drug interactions. The chapter concludes by providing an overview of recent advances in quercetin development, including nanoformulations, targeted delivery systems, and combination therapies, that hold promise for enhancing its therapeutic efficacy and bioavailability. This comprehensive exploration of quercetin aims to provide researchers, scientists, and healthcare professionals with valuable insights into its multifaceted nature and potential applications in human health.

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Advanced Nanomaterials for Cancer Therapy: Gold, Silver, and Iron Oxide Nanoparticles in Oncological Applications

Singh,

Pandit,

Balusamy

et al. 2024

Adv Healthcare Materials

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Cancer remains one of the most challenging health issues globally, demanding innovative therapeutic approaches for effective treatment. Nanoparticles, particularly those composed of gold, silver, and iron oxide, have emerged as promising candidates for changing cancer therapy. This comprehensive review demonstrates the landscape of nanoparticle‐based oncological interventions, focusing on the remarkable advancements and therapeutic potentials of gold, silver, and iron oxide nanoparticles. Gold nanoparticles have garnered significant attention for their exceptional biocompatibility, tunable surface chemistry, and distinctive optical properties, rendering them ideal candidates for various cancer diagnostic and therapeutic strategies. Silver nanoparticles, renowned for their antimicrobial properties, exhibit remarkable potential in cancer therapy through multiple mechanisms, including apoptosis induction, angiogenesis inhibition, and drug delivery enhancement. With their magnetic properties and biocompatibility, iron oxide nanoparticles offer unique cancer diagnosis and targeted therapy opportunities. This review critically examines the recent advancements in the synthesis, functionalization, and biomedical applications of these nanoparticles in cancer therapy. Moreover, the challenges are discussed, including toxicity concerns, immunogenicity, and translational barriers, and ongoing efforts to overcome these hurdles are highlighted. Finally, insights into the future directions of nanoparticle‐based cancer therapy and regulatory considerations, are provided aiming to accelerate the translation of these promising technologies from bench to bedside.

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Green Nanotechnology as an innovative drug delivery approach for Typha capensis and Naringenin—New class of phytochemical embedded biocompatible gold nanoparticles in prostate cancer therapy

Cited by 10 publications

References 44 publications

Testosterone restores TM3 and TM4 cell viability, reduces reactive oxygen species generation, and protects against atrazine‐induced stereological changes in rat testes

Testosterone restores TM3 and TM4 cell viability, reduces reactive oxygen species generation, and protects against atrazine‐induced stereological changes in rat testes

Unveiling the Potential of Quercetin: Chemistry, Health Benefits, Toxicity, and Cutting-Edge Advances

Advanced Nanomaterials for Cancer Therapy: Gold, Silver, and Iron Oxide Nanoparticles in Oncological Applications

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