Nanotechnology has revolutionised biomedical research, offering innovative healthcare solutions. Plant-based nanotechnology is emerging as a sustainable alternative, minimising environmental impacts and enhancing therapeutic effectiveness. This paper explores the potential of plant-derived nanoparticles (PNPs) in medicine, highlighting their biocompatibility, multifunctionality, and eco-friendliness. PNPs, synthesised through green methods, have demonstrated promising applications in drug delivery, cancer therapy, antimicrobial treatments, and tissue regeneration. Their unique properties, such as a high surface area and bioactive components, enable improved drug delivery, targeting, and controlled release, reducing side effects and enhancing treatment efficacy. Additionally, plant-derived compounds’ inherent antimicrobial and antioxidant properties, retained within platinum nanoparticles (PNPs), present innovative opportunities for combating antimicrobial resistance and promoting wound healing. Despite their potential, challenges remain in standardising PNP synthesis, ensuring consistency, and scaling up production for industrial applications. This review emphasises the need for further research on PNP toxicity, biocompatibility, and regulatory frameworks to fully harness their capabilities in clinical and commercial applications. Plant-based nanotechnology represents a promising, greener alternative for advancing healthcare solutions, aligning with global sustainability goals.