Green pH- and magnetic-responsive hybrid hydrogels based on poly(methacrylic acid) and Eucalyptus wood nanocellulose for controlled release of ibuprofen

Markovič, Maja; Šešlija, Sanja I.; Ugrinović, Vukašin; Kunaver, Matjaž; Panic, Vesna V.; Pjanović, Rada; Spasojević, Pavle

doi:10.1007/s10570-021-04222-w

Cited by 18 publications

(6 citation statements)

References 78 publications

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“…[26] Additionally, the easy inclusion of responsive components enables stimulus-responsive drug release based on temperature, pH, or magnetic field. [19,48] The cytocompatibility of the CNC reinforced hydrogels for normal human dermal fibroblast (NHDF) cells was evaluated by measuring the metabolic activity of NHDF cells after exposure to different hydrogel formulations. The cellular metabolic activity of cells in contact with the two formulations of the hydrogels, L1 (4 wt.% CNC, 6 wt.% PNIPAM) and L2 (6 wt.% CNC, 6 wt.% PNI-PAM) was tested using an AlamarBlue assay (Figure 2C).…”

Section: Liquid Injectable Hydrogels Targeting Local Therapeutic Admi...mentioning

confidence: 99%

Versatile Mechanically Tunable Hydrogels for Therapeutic Delivery Applications

Sun,

Tao,

Bovone

et al. 2024

Adv Healthcare Materials

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Hydrogels provide a versatile platform for biomedical material fabrication that can be structurally and mechanically fine‐tuned to various tissues and applications. Applications of hydrogels in biomedicine range from highly dynamic injectable hydrogels that can flow through syringe needles and maintain or recover their structure after extrusion to solid‐like wound‐healing patches that need to be stretchable while providing a selective physical barrier. In this study, a toolbox is designed using thermo‐responsive poly(N‐isopropylacrylamide) (PNIPAM) polymeric matrices and nanocelluloses as reinforcing agent to obtain biocompatible hydrogels with altering mechanical properties, from a liquid injectable to a solid‐like elastic hydrogel. The liquid hydrogels possess low viscosity and shear‐thinning properties at 25°C, which allows facile injection at room temperature, while they become viscoelastic gels at body temperature. In contrast, the covalently cross‐linked solid‐like hydrogels exhibit enhanced viscoelasticity. The liquid hydrogels are biocompatible and are able to delay the in vitro release and maintain the bioactivity of model drugs. The antimicrobial agent loaded solid‐like hydrogels are effective against typical wound‐associated pathogens. This work presents a simple method of tuning hydrogel mechanical strength to easily adapt to applications in different soft tissues and broaden the potential of renewable bio‐nanoparticles in hybrid biomaterials with controlled drug release capabilities.This article is protected by copyright. All rights reserved

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Section: Liquid Injectable Hydrogels Targeting Local Therapeutic Admi...mentioning

confidence: 99%

Versatile Mechanically Tunable Hydrogels for Therapeutic Delivery Applications

Sun,

Tao,

Bovone

et al. 2024

Adv Healthcare Materials

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“…As a general rule, the addition of nanocellulose to the matrix typically inhibits the diffusion of drug molecules and reduces the diffusion flux k, leading to a longer and more controlled drug release. 20,114,143 Since hydrogel matrices are commonly biodegradable materials, the degradation and swelling of the matrix become more pronounced at longer time scales. Compared to before the addition of nanocellulose, the value of n during drug release usually increases significantly, indicating a raising influence of matrix degradation/swelling in the drug release process over longer time scales.…”

Section: Regulation Of Drug Releasementioning

confidence: 99%

“…180 For example, dual responsive hydrogels based on poly(methacrylic acid), CNCs and Fe 3 O 4 particles were proposed to target ibuprofen delivery. 143 When exposed to the external magnetic field, the hydrogels showed a magnetocaloric effect, and the magnetic field directly to the acting site shortened the path and circulation time of drug delivery. Besides, a magnetic hydrogel based on a nanocellulose analog, nanochitin, has been proposed, which shows the ability of thermal ablation of osteosarcoma cells through the remote heating of alternating electromagnetic fields.…”

Section: Journal Of Materials Chemistry B Reviewmentioning

confidence: 99%

Nanocellulose-based hydrogels for drug delivery

Lin

Zhao

et al. 2023

J. Mater. Chem. B

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“…Hence, these materials have great potential as drug carriers and for targeted drug delivery. In addition to the pH sensitivity of PMAA nanohydrogels, some other unique features such as excellent biocompatibility, nontoxicity, tunable size, ease of functionalization, and modi cation make this nanocarrier an ideal candidate for targeted drug delivery [13,14]. Beside these, enzyme-responsive polymer nanohydrogels can also be used as an effective drug delivery which triggering its cargo in response to the lysosomal condition.…”

Section: Introductionmentioning

confidence: 99%

Targeted co-delivery of methotrexate and chloroquine via a pH/enzyme-responsive biocompatible polymeric nanohydrogel for colorectal cancer treatment

Rashidzadeh

Ramazani

Rezaei

et al. 2023

Journal of Biomaterials Science, Polymer Edition

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Application of conventional chemotherapy regardless of its unique effectiveness have been gradually being edged aside due to limited targeting capability, lack of selectivity and chemotherapy-associated side effects. To this end, colon-targeted nanoparticles via combination therapy have shown great therapeutic potential against cancer. Herein, pH/enzyme-responsive biocompatible polymeric nanohydrogels based on poly(methacrylic acid) (PMAA) containing methotrexate (MTX) and chloroquine (CQ) were fabricated. PMAA-MTX-CQ exhibited high drug loading e cacy of which MTX was 4.99% and was CQ 25.01% and displayed pH/enzyme-triggered drug release behavior. Higher CQ release rate (76%) under simulated acidic microenvironment of tumor tissue whereas 39% of CQ was released under normal physiological conditions. Intestinally, MTX release was facilitated in the presence of proteinase K enzyme. TEM image demonstrated spherical morphology with particle size of less than 50 nm. In vitro and in vivo toxicity assessments indicated that developed nanoplatforms possessed great biocompatibility. These nanohydrogels did not cause any adverse effects against Artemia Salina and HFF2 cells (around 100% cell viability) which highlight the safety of prepared nanohydrogels. There was no death in mice received different concentrations of nanohydrogel through oral administration and less than 5% hemolysis was found in red blood cells incubated with PMAA nanohydrogels. In vitro anti-cancer results showed that combination therapy based on PMAA-MTX-CQ can effectively suppress the growth of SW480 colon cancer cells (29% cell viability) compared to monotherapy. Altogether, these ndings suggest that pH/enzyme-responsive PMAA-MTX-CQ could effectively inhibit cancer cell growth and progression via site-speci c delivery of its cargo in a safe and controlled manner.

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Green pH- and magnetic-responsive hybrid hydrogels based on poly(methacrylic acid) and Eucalyptus wood nanocellulose for controlled release of ibuprofen

Cited by 18 publications

References 78 publications

Versatile Mechanically Tunable Hydrogels for Therapeutic Delivery Applications

Versatile Mechanically Tunable Hydrogels for Therapeutic Delivery Applications

Nanocellulose-based hydrogels for drug delivery

Targeted co-delivery of methotrexate and chloroquine via a pH/enzyme-responsive biocompatible polymeric nanohydrogel for colorectal cancer treatment

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