Green synthesis and anticancer potential of chalcone linked-1,2,3-triazoles

Synthesis, characterization, and antifungal evaluation of novel 1,2,3-triazolium-functionalized starch derivative

“…The effective functionalization of 6-azido-6-deoxy starch is further confirmed by the presence of the protons of -CH2N3 at 3.77 ppm [22]. The new signal at high frequency (7.62 ppm) is produced by the hydrogen at 5-H position of 1,2,3-triazole, which demonstrates that the 1,2,3-triazole group has been successfully introduced to starch backbone [13,31].…”

“…Moreover, the chemical structures of starch and the synthesized starch derivatives are further confirmed by 13 C NMR spectra. The 13 C NMR spectrum of starch reveals the carbons in the pyranose ring at around 60-100 ppm [34].…”

“…1 H Nuclear magnetic resonance ( 1 H NMR) and 13 C Nuclear magnetic resonance ( 13 C NMR) spectra were all recorded on a Bruker AVIII-500 Spectrometer (Bruker Tech. and Serv.…”

“…1,2,3-triazole moiety formed by cuprous-catalyzed azide-alkyne cycloaddition (CuAAC) has emerged as attractive heterocyclic compounds in biochemistry and pharmaceutical research due to their wide range of biological properties, such as antimicrobial, anticancer, and antimalarial [11][12][13][14]. These interesting biological properties can facilitate the chemical modification of starch with 1,2,3-triazoles [15,16].…”

“…The chemical structures of the derivatives were characterized by FTIR, UV-vis, 1 H NMR, 13 C NMR, and elemental analysis. Three plant-threatening fungi, Colletotrichum lagenarium (C.…”