Green synthesis and biological screening of some fluorinated pyrazole chalcones in search of potent anti-inflammatory and analgesic agents

Jadhav, Shravan Y.; Peerzade, Nargisbano A.; Gawali, Rakhi G; Bhosale, Raghunath B.; Kulkarni, Amol A.; Varpe, Bhushan D.

doi:10.4103/epj.epj_64_19

Cited by 9 publications

(3 citation statements)

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“…All of the compounds were found to be within the permissible druglikeness parameters, which include M.W., HBD, HBA, and log P. 34 The conjugates were predicted to have high gastrointestinal absorption. Except conjugate ITF 4, all the compounds are predicted as (Blood Brain Barrier) BBB permeants.…”

Section: In Silico Admementioning

confidence: 92%

Schiff Base Conjugate of 5-Fluoroisatin with Thiophene-2-Ethylamine and its Mannich Bases: Synthesis, Molecular Docking, and Evaluation of in vitro Anti-inflammatory and Anti-tubercular Activity

Varpe¹,

Jadhav²

2021

JPHI

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Section: In Silico Admementioning

confidence: 92%

Schiff Base Conjugate of 5-Fluoroisatin with Thiophene-2-Ethylamine and its Mannich Bases: Synthesis, Molecular Docking, and Evaluation of in vitro Anti-inflammatory and Anti-tubercular Activity

Varpe¹,

Jadhav²

2021

JPHI

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“…The effectiveness of sonication is evident—a 10% increase in yield in 1/20 the reaction time. Jadhava’s team used PEG-400 as a benign solvent to mediate the condensation of 4-fluoroacetophenone 84 and a series of pyrazole carbaldehydes 85 en route to eight fluorinated pyrazolyl hybrid chalcones 86 [ 60 ]. Kudlickova and coworkers employed a mechanochemical ball-milling process to prepare a series of indoylchalcones 92 in yields ranging from 28 to 79% in only 30 min [ 61 ].…”

Section: B-ring Heteroaromatic Hybrid Chalcone Synthesismentioning

confidence: 99%

Advances in the Synthesis of Heteroaromatic Hybrid Chalcones

Mallia

Sloop

2023

Molecules

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Chalcones continue to occupy a venerated status as scaffolds for the construction of a variety of heterocyclic molecules with medicinal and industrial properties. Syntheses of hybrid chalcones featuring heteroaromatic components, especially those methods utilizing green chemistry principles, are important additions to the preparative methodologies for this valuable class of molecules. This review outlines the advances made in the last few decades toward the incorporation of heteroaromatic components in the construction of hybrid chalcones and highlights examples of environmentally responsible processes employed in their preparation.

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“…Pyrimidines ring is also present in vitamin B2 and folic acid having different biological activities. [30][31] The wide spectrum pharmacological effects of different pyrimidine derivatives prompted us to design the pyrimidines synthesis by treating guanidine hydrochloride as well as urea in presence of basic catalyst with various chalcones to obtain a series of substituted pyrimidine derivatives.…”

Section: Introductionmentioning

confidence: 99%

Green Synthesis and Biological Screening of Imidazo [2,1-B] Thiazole Pyrimidines as Potent Anti-Bacterial Agents

Sonawane¹,

Bhosale²,

Rashinkar³

et al. 2022

YMER

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A series of Imidazo[2,1-b]thiazole pyrmidine derivatives (3a-g-) were designed, synthesized from imidazo[2,1-b]thiazole chalcone derivatives. (2a-g) and Urea in PEG-400 and evaluated for their anti-bacterial potency. Characterization of newly synthesized compounds was done using IR and 1H NMR and Mass spectroscopy. Further Imidazo [2,1-b]thiazole pyrimidine derivatives were subjected to check their anti-bacterial activities against four different strains, viz two Gram +ve bacteria Staphylococcus aureus & Bacillus subtilis and two Gram -ve bacteria Escherichia coli & Pseudomonas aeruginosa by using Well diffusion method for the determination of zone of inhibition as antibacterial activity of the synthesized compounds. KEY WORDS: Imidazo[2,1-b]thiazole Chalcones, Imidazo[2,1-b]thiazole 4-carbaldehyde, Imidazo[2,1-b]thiazole pyrimidines, PEG-400, anti-inflammatory activity

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Green synthesis and biological screening of some fluorinated pyrazole chalcones in search of potent anti-inflammatory and analgesic agents

Cited by 9 publications

References 0 publications

Schiff Base Conjugate of 5-Fluoroisatin with Thiophene-2-Ethylamine and its Mannich Bases: Synthesis, Molecular Docking, and Evaluation of in vitro Anti-inflammatory and Anti-tubercular Activity

Schiff Base Conjugate of 5-Fluoroisatin with Thiophene-2-Ethylamine and its Mannich Bases: Synthesis, Molecular Docking, and Evaluation of in vitro Anti-inflammatory and Anti-tubercular Activity

Advances in the Synthesis of Heteroaromatic Hybrid Chalcones

Green Synthesis and Biological Screening of Imidazo [2,1-B] Thiazole Pyrimidines as Potent Anti-Bacterial Agents

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