Green synthesis and characterization of silver and iron nanoparticles using Nerium oleander extracts and their antibacterial and anticancer activities

Abstract

Medicinal plants can be used as reducing agents in the preparation of metal nanoparticles by green synthesis because of the chemotherapeutic and anti-infectious properties of natural compounds. Therefore, this paper reports the green synthesis of silver and iron nanoparticles from leaf and flower extracts of Nerium oleander and their capacity as anticancer and antimicrobial agents. Nanoparticle manufacturing and structural characterization of silver and iron nanoparticles are reported. The formation of nanoparticles is characterized by scanning electron microscopy with energy dispersive X-ray spectroscopy, UV-Vis and Fourier transform infrared (FTIR) spectroscopy. Nanoparticles formation was also investigated the surface charge, particle size, and distribution using zeta sizer analysis by DLS. Green synthesis of silver and iron nanoparticles using N. oleander showed different levels of selective cytotoxicity against K562 (human chronic myeloid leukemia cells) in low concentrations and were not cytotoxic to the HUVEC (human umbilical vein endothelial cells) in the same concentrations. Silver nanoparticles showed antibacterial activity against multidrug pathogens, while iron nanoparticles failed to show such activity. Results of the present research demonstrate the potential use of green synthesized nanoparticles in various biomedicine and pharmaceuticals fields in the future.

Biogenic synthesis of RICINUS COMMUNIS mediated iron and silver nanoparticles and its antibacterial and antifungal activity

“…Therefore, plant-based biogenic synthesis of nanoparticles has antibacterial potency due to affluent sources of metabolites with medicinal properties [ 10 ]. Iron and silver nanoparticles have been synthesized using numerous plants [ 11 ], such as Erodium cicutarium [ 12 ] and Nerium oleander [ 13 ]. Among these plants, Ricinus communis (castor) is a flowering plant used as an antioxidant, fungicide, antiulcer, wound healer, laxative, antiasthmatic, and insecticide agent.…”