Green Synthesis, Molecular Docking, In Silico ADME and Biological Evaluation of Methoxy Substituted 1,5-Benzodiazepines as Potential Antioxidant, Anti-Inflammatory, and Antidiabetic Agents

Schiff Base Conjugate of 5-Fluoroisatin with Thiophene-2-Ethylamine and its Mannich Bases: Synthesis, Molecular Docking, and Evaluation of in vitro Anti-inflammatory and Anti-tubercular Activity

“…The anti-inflammatory activity of conjugates was investigated by analyzing percentage inhibition of denaturation of the BSA technique 19,[25][26][27][28] using the reported method. The sample containing test compound and 1% aqueous solution of the BSA fraction was prepared and the pH of the mixture was adjusted to pH 6.3 using a small amount of dilute hydrochloric acid.…”

Chalcone derived benzoheterodiazepines for medicinal applications: A Two‐pot and one‐pot synthetic approach

“…Benzodiazepines and benzothiazepines played a prominent role in drug research during the last three decades [34]. Their derivatives are also equally significant in pharmaceutical applications with a wide spectrum of biological properties such as antiinfectives [35], antiarrhythmic [36], anthelmintic [37], anticancer [38][39][40][41][42], antifidant [43], antihypnotic [44], antihypertensive [45], anticonvulsant [46,47], antioxidant [48,49], antidiabetic [50], antiHIV [24,51,52], antifungal [53], antidepressant [54], antimicrobial [55], antituberculosis [18], antineoplastics [56], anti-inflammatory [57] as well as inhibitors for cholinesterase [58] and neurological disorders [59]. Benzoheterodiazepine derivatives have also been reported as corrosion inhibitors [60], dyes for the acrylic fibers [57] in photography, photographic emulsions [61], and lubricating oil with antioxidant properties [62].…”