Green synthesis of 5-hydroxymethylfurfural through non-catalytic conversion of glucose in a microreactor

Tongtummachat, Tiprawee; Jaree, Attasak; Akkarawatkhoosith, Nattee

doi:10.1016/j.ecmx.2021.100141

Cited by 6 publications

(12 citation statements)

References 31 publications

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“…But above the optimum value, the contamination of MIBK with water also increased which further enhanced the hydration of HMF present in the MIBK phase, which was contaminated with water, thereby decreasing HMF yield and selectivity . Another problem with a very high organic phase-to-aqueous phase ratio is the reduced mass-transfer area between the organic and aqueous phases . Furthermore, a very high residence time in a microreactor decreases the HMF yield, because of the dehydration of HMF into levulinic acid …”

Section: Hmf Synthesis From Sugarsmentioning

confidence: 99%

“…42 However, it is important to not use excess organic phase volume because it leads to a decrease in the HMF yield. 44 Excess organic phase results in H 2 O entering into the organic phase with the catalyst, which again promotes side reactions in the organic phase and decreases HMF yield. Therefore, it is essential to limit the diffusion of catalyst into the organic phase, maintain high catalyst concentration in the aqueous phase, and, at the same time, ensure a high organic phase/aqueous phase ratio.…”

Section: Solvents For Hmf Synthesismentioning

confidence: 99%

“…They are a promising novel reactor, especially for reactions with multiphase solvent systems. 44 However, when they are used for converting sugars into HMF, humins formed as a byproduct can stick to the inner surface walls of the microreactor. To prevent this, slug flow operation was followed in the microreactor.…”

Section: Continuous Conversion Of Sugars Into Hmfmentioning

confidence: 99%

“…69 Another problem with a very high organic phaseto-aqueous phase ratio is the reduced mass-transfer area between the organic and aqueous phases. 44 Furthermore, a very high residence time in a microreactor decreases the HMF yield, because of the dehydration of HMF into levulinic acid. 44 A comparative study between batch and microreactor for HMF synthesis from fructose revealed that 80% HMF yield from microreactor was achieved within <10 min.…”

Section: Continuous Conversion Of Sugars Into Hmfmentioning

confidence: 99%

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A Review on Green and Efficient Synthesis of 5-Hydroxymethylfurfural (HMF) and 2,5-Furandicarboxylic Acid (FDCA) from Sustainable Biomass

Aranha

Gogate

2023

Ind. Eng. Chem. Res.

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The present work gives an overview of the approaches for green synthesis of 5-hydroxymethylfurfural (HMF) and 2,5 furan dicarboxylic acid (FDCA) focusing on reduction in the byproduct formation such as levulinic acid and humins. It was elucidated that the use of highly polar and aqueous solvents, high Brønsted acidity, high pH, reaction time, and temperature increases the levulinic acid formation in the reaction. In contrast, humin formation is increased by high basicity, temperature, and initial substrate concentration. Specific catalytic and solvent systems for minimizing the byproduct formation during HMF synthesis are also discussed along with options for use of microwave, ultrasound, and continuous processes. In terms of intensification, safety, and ease of scale-up, the use of ultrasound for HMF synthesis is promising; however, microreactors are currently a better choice for higher substrate concentration usage and higher yields. Effect of parameters like reaction time, temperature, oxidizing source, solvent, and base on FDCA synthesis is also analyzed. Depending on the reaction conditions and the reactor type, the optimum temperature typically should be between 80 and 160 °C, moderate bases, such as K2CO3 and KHCO3, are preferred to maintain a preferred pH of 7−11 and O2 is an ideal oxidizing agent. The reaction pathway for FDCA synthesis from HMF was also studied and the effect of the base and solvent elucidated. Finally, one-pot synthesis of FDCA from HMF and the strategies necessary to optimize the FDCA yield has been discussed. It was demonstrated that one-pot two-step FDCA synthesis from sugars provides enhanced FDCA yield, selectivity, and lower byproduct formation, compared to one-pot one-step synthesis.

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Section: Hmf Synthesis From Sugarsmentioning

confidence: 99%

Section: Solvents For Hmf Synthesismentioning

confidence: 99%

Section: Continuous Conversion Of Sugars Into Hmfmentioning

confidence: 99%

Section: Continuous Conversion Of Sugars Into Hmfmentioning

confidence: 99%

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A Review on Green and Efficient Synthesis of 5-Hydroxymethylfurfural (HMF) and 2,5-Furandicarboxylic Acid (FDCA) from Sustainable Biomass

Aranha

Gogate

2023

Ind. Eng. Chem. Res.

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“…One alternative solution is to use a biphasic reaction system with a water-immiscible organic phase such as methyl isobutyl ketone, methyl tetrahydrofuran or butanol. [19][20][21] In such systems, the fructose is dehydrated in the aqueous phase by an acid catalyst to produce 5-HMF, which is then extracted into the organic phase, thus avoiding the further degradation of 5-HMF in the aqueous solution, and the resulting 5-HMF is obtained in a yield of up to 75%. 22 The advantage of this process is that the fructose concentration in the aqueous phase can be very high, which facilitates a higher space-time yield of the reaction.…”

Section: Introductionmentioning

confidence: 99%

Insight into the dehydration of high-concentration fructose to 5-hydroxymethylfurfural in oxygen-containing polar aprotic solvents

et al. 2022

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Nanoparticles for the synthesis of bio‐based chemical 5‐Hydroxymethyl furfural from agricultural waste and biomass‐derived carbohydrates‐A review

Anjali,

Veluturla,

Saranya

et al. 2024

J of Chemical Tech & Biotech

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The need for 5‐Hydroxymethylfurfural (HMF) has garnered significant attention due to its versatile application in the chemical industry as a precursor for biofuels, pharmaceuticals and fine chemicals. This abstract summarizes a complete review on the synthesis of HMF using heterogeneous catalyst from agriculture waste and various biomass‐derived carbohydrates, focusing on their efficiency, selectivity and industrial feasibility. This review systematically outlines the diverse classes of heterogeneous catalyst employed in HMF production, including Titanium dioxide (TiO2), Zirconium dioxide (ZrO2), Silicon dioxide (SiO2), Aluminium oxide (Al2O3) where the discussion highlights their catalytic mechanisms and intrinsic properties that influence HMF yield, selectivity, stability and reusability. In addition, the impact of reaction parameters such as temperature, pressures, solvents, feedstock's composition and catalyst morphology on HMF synthesis has been assessed. This review consolidates the current state‐ methodologies in the synthesis of 5‐Hydroxymethyl furfural using various heterogeneous nanoparticle catalysts.This article is protected by copyright. All rights reserved.

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Green synthesis of 5-hydroxymethylfurfural through non-catalytic conversion of glucose in a microreactor

Cited by 6 publications

References 31 publications

A Review on Green and Efficient Synthesis of 5-Hydroxymethylfurfural (HMF) and 2,5-Furandicarboxylic Acid (FDCA) from Sustainable Biomass

A Review on Green and Efficient Synthesis of 5-Hydroxymethylfurfural (HMF) and 2,5-Furandicarboxylic Acid (FDCA) from Sustainable Biomass

Insight into the dehydration of high-concentration fructose to 5-hydroxymethylfurfural in oxygen-containing polar aprotic solvents

Nanoparticles for the synthesis of bio‐based chemical 5‐Hydroxymethyl furfural from agricultural waste and biomass‐derived carbohydrates‐A review

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