Green synthesis of carbon quantum dots and their application as a fluorometric sensor for highly selective determination of 6-mercaptopurine in biological samples

Saboorizadeh, Bahar; Zare‐Dorabei, Rouholah; Shahbazi, Neda

doi:10.1016/j.jtice.2021.09.015

Cited by 35 publications

(9 citation statements)

References 35 publications

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“…Shuang’s group designed an anthraquinone–imidazole-based colorimetric and fluorescent sensor for the analysis of Ag(I) and thiols . Zare-Dorabei’s groups synthesized diphenylthiocarbazone immobilized on the triacetyl cellulose membrane, a nanocomposite containing silver sulfide QDs and graphitic carbon nitride nanosheets (g-C 3 N 4 NNs), and a series of nanomaterials to detect Ag(I), small biological molecules, and other hazardous substances. − Liao’s group prepared the g-C 3 N 4 NNs/polyacrylamide/polyacrylic acid composite hydrogel by using the radical polymerization method, which can act as a fluorescent probe to detect Ag(I) with a limit of detection (LOD) of 6.31 μmol L –1 . Chen’s group synthesized the acetaldehyde-modified g-C 3 N 4 NNs through the ethylene glycol-assisted liquid exfoliation method, which was successfully used to detect Ag(I) based on the photo-induced electron transfer (PET) .…”

Section: Introductionmentioning

confidence: 99%

Graphitic Carbon Nitride Quantum Dots in Dual-Mode Fluorescence Switching Platforms for Trace Analysis of Ag(I) and l-Cysteine

Guo

Yang

Wei

et al. 2022

ACS Appl. Nano Mater.

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Graphitic carbon nitride quantum dots (g-C 3 N 4 QDs) are synthesized using a simple, one-pot, and methylamine-assisted hydrothermal method. This material with excellent fluorescence property can be contracted in dual-mode fluorescence switching platforms for trace analysis of Ag(I) and cysteine. Upon adding Ag(I), the fluorescence intensity of g-C 3 N 4 QDs is quenched quickly, but its fluorescence resonance light scattering (RLS) intensity increases owing to the synergistic mechanism between photoinduced electron transfer and chelation mechanisms. Upon subsequently adding cysteine, the fluorescence intensity of g-C 3 N 4 QDs recovers rapidly; however, its RLS intensity decreases obviously due to the strong binding ability between Ag(I) and thiols. According to this interesting reaction mechanism, an "on−off−on" and "off−on−off" dual-mode fluorescence switching sensor exhibits high selectivity and sensitivity for simultaneously analyzing Ag(I) and cysteine, and the detection limits are calculated to be 8.0 and 10.3 nmol L −1 , respectively. The present study also displays excellent analytical performance for the analysis of Ag(I) and cysteine in natural samples.

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Section: Introductionmentioning

confidence: 99%

Graphitic Carbon Nitride Quantum Dots in Dual-Mode Fluorescence Switching Platforms for Trace Analysis of Ag(I) and l-Cysteine

Guo

Yang

Wei

et al. 2022

ACS Appl. Nano Mater.

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“…Saboorizadeh et al. synthesized CQDs from sweet potatoes by the hydrothermal method . Nagaraj et al hydrothermally treated the fruits of Borassus flabellifer to produce carbon quantum dots …”

Section: Introductionmentioning

confidence: 99%

“…synthesized CQDs from sweet potatoes by the hydrothermal method. 17 Nagaraj et al hydrothermally treated the fruits of Borassus flabellifer to produce carbon quantum dots. 18 The conventional preparation method of CQDs is frequently not sustainable in terms of feedstock or a synthesis pathway.…”

Section: ■ Introductionmentioning

confidence: 99%

Energy-Efficient, Room-Temperature, and Facile Synthesis of Carbon Quantum Dots from Interstitial Compound TiC for the Selective Detection of Fe(III)

Wang,

Bai,

Zhou

et al. 2023

ACS Sustainable Chem. Eng.

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The synthesis of carbon quantum dots (CQDs) from renewable resources is extensively regarded as a green approach, but this method is generally accompanied by high energy consumption and complex byproducts, which limit the large-scale production of CQDs. In this work, titanium carbide-derived CQDs (TiC-CQDs) were synthesized only by mixing titanium carbide and hydrogen peroxide (1 wt %) at room temperature. The resulting byproduct was converted to a precipitate by sodium hydroxide to purify the TiC-CQDs, and the reaction mechanism was further explored. The average lateral size of TiC-CQDs is 4.2 ± 1.1 nm and shows excellent fluorescence properties. Moreover, in an acetic acid-sodium acetate buffer solution, the fluorescence of TiC-CQDs could be selectively quenched by a ferric ion (Fe 3+ ) with a broad concentration range of 0.2−5 μM and 5−60 μM and a detection limit as low as 0.14 μM. Due to the absence of the energy input, complex equipment, and nontoxic and harmless precursors, the novel room-temperature synthesis route of TiC-CQDs is energy-efficient, safe, green, and economical, and has great potential in industrial application.

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“…In this regard, several fluorometric sensors have been developed based on CQDs to determine various chemical and biochemical species such as metal ions, drugs, water pollutants, and proteins, to name a few. ,− Due to the sensitivity of the CQDs in sensing applications and the importance of monitoring medication uptake, drug detection is one of the appealing branches of CQD-based fluorometric sensors. − For instance, Feng et al have used nitrogen-doped CQDs functionalized with molecularly imprinted polymers for doxycycline determination based on fluorescence quenching. In another study, the fluorescence resonance energy transfer (FRET) mechanism was used to detect the gemcitabine drug via silver nanoparticle–CQD nanocomplex by Shekarbeygi and colleagues .…”

Section: Introductionmentioning

confidence: 99%

“…In a similar study, CQD-based nanocomposite with silver nanostructure was used for methimazole determination (an antithyroid drug) . Other mechanisms can also be used to develop a CQD-based fluorometric detection, such as fluorescence enhancement, photo-induced electron transfer (PET), and inner filter effect (IFE). ,− …”

Section: Introductionmentioning

confidence: 99%

Intrinsic Dual-Emitting Carbon Quantum-Dot-Based Selective Ratiometric Fluorescent Mercaptopurine Detection

Saboorizadeh

Zare‐Dorabei

2022

ACS Biomater. Sci. Eng.

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, an immunosuppressive drug, has been widely prescribed for treating leukemia and autoimmune diseases. The level of the 6-MP drug in body fluids is of great interest due to the severe health problems related to its overdose. This study used a facile microwave preparation route to synthesize carbon quantum dots (CQDs) using glutathione and formamide as carbon sources. The obtained monodispersed quantum dots showed dual fluorescence emission with a sensitive affinity toward the 6-MP drug. The sensor's response was optimized by tuning the temperature, pH, and volume ratio of the probe. The prepared ratiometric fluorescence method showed accurate measurements for determining mercaptopurine in aqueous solutions in the concentration range of 1.4−7.6 mg L −1 with the limit of detection of 1.3 mg L −1 . The sensor's performance was assessed in complex solutions, human urine, and human plasma sample and recovery values in the range of 88− 127% were obtained. The reliable dual fluorometric sensor showed promising results for 6-MP determination and potential application for the determination of other chemical and biochemical species.

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Green synthesis of carbon quantum dots and their application as a fluorometric sensor for highly selective determination of 6-mercaptopurine in biological samples

Cited by 35 publications

References 35 publications

Graphitic Carbon Nitride Quantum Dots in Dual-Mode Fluorescence Switching Platforms for Trace Analysis of Ag(I) and l-Cysteine

Graphitic Carbon Nitride Quantum Dots in Dual-Mode Fluorescence Switching Platforms for Trace Analysis of Ag(I) and l-Cysteine

Energy-Efficient, Room-Temperature, and Facile Synthesis of Carbon Quantum Dots from Interstitial Compound TiC for the Selective Detection of Fe(III)

Intrinsic Dual-Emitting Carbon Quantum-Dot-Based Selective Ratiometric Fluorescent Mercaptopurine Detection

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