Green synthesis of Cobalt Nanoparticles using Ethanolic extract of Cadiospermum halicacebium Characterisation and its anticancer applications

Malathy, D.; Revathi, M.

doi:10.5958/0974-360x.2021.00271.7

Cited by 2 publications

(1 citation statement)

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“…Their results showed effective antibacterial activity against the pathogenic bacteria [14]. The present study followed a similar protocol to synthesize Co-NPs using Limonia acidissima leaf extract with a few modifications, as described by a study that used cobalt nitrate to synthesize NPs [21]. Significant antimicrobial activity of these Co-NPs against all the tested Gram positive and Gram negative bacteria and two Candida spp.…”

Section: Cobaltmentioning

confidence: 99%

Medicinal Properties of Cobalt and Copper Nanoparticles Synthesized Using Limonia acidissima Leaf Extract

Panicker,

Mathew,

Dalvi

et al. 2024

BJI

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Aim: The present investigation was undertaken to synthesize Cobalt and copper nanoparticles (NPs) using Limonia acidissima L. leaf extract and to test their few medicinal properties like antimicrobial antioxidant and anti-diabetic activities. Methodology: Limonia acidissima plant leaves were collected from the vicinity of the College and the study was completed in 11 months. The hot aqueous leaf extract and soxhlet extract using ethyl acetate as solvent were prepared. Phytochemical analysis of the leaf extract showed the presence of Tannins, Flavonoids, Alkaloids and absence of Phenols. The leaf extract was then used to make Cobalt and copper nanoparticles (NPs) using Cobalt acetate and Copper sulphate respectively. Results: The formation of NPs was checked by color change and confirmed with UV–visible spectrophotometry. The typical peaks of Co-NPs were detected in the range of maximum wavelength between 380-520 nm and that for Cu NPs was detected between 260-580 nm. The antimicrobial activity of the synthesized NPs of both metal oxides was then tested against Gram positive and Gram negative bacteria and also against two Candida sps. Cobalt NPs exhibited strong antimicrobial activity against all tested organisms but Copper NPs showed no antimicrobial activity. The both NPs were also tested for antioxidant and anti-diabetic properties. Comparatively the Copper NPs possessed higher antioxidant and anti-diabetic activity than the cobalt nanoparticles. Conclusion: Thus, this underutilized plant from India can be further exploited for more medicinal properties and bring it into pharmaceutical usage.

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Section: Cobaltmentioning

confidence: 99%

Medicinal Properties of Cobalt and Copper Nanoparticles Synthesized Using Limonia acidissima Leaf Extract

Panicker,

Mathew,

Dalvi

et al. 2024

BJI

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Anticancer cytotoxicity and antifungal abilities of green-synthesized cobalt hydroxide (Co(OH)2) nanoparticles using Lantana camara L.

Ravi¹,

Sreenivas²,

Kumari³

et al. 2022

Beni-Suef Univ J Basic Appl Sci

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Background Green synthesis of metal nanoparticles with pharmaceutical applications is the current focus in the field of nanomedicine. This study aims at use of Lantanacamara L as a source of green reducing agent toward synthesis of cobalt nanoparticles. Results Fe3+-reducing assay demonstrated that Lantana camara methanol extract (LCM) has significant electron transfer potential. Gas chromatography mass spectroscopy (GC–MS) analysis of the crude extracts revealed the presence of 7 known and 17 unknown phytochemicals in LCM. Synthesis of cobalt nanoparticles was confirmed based on color change of reaction mixture from light brown to dark brown. UV–visible spectrometry analysis showed that the synthesized particles had a λmax at 267.5 nm. Based on the two theta (2θ) and Miller indices (hkl) values obtained in XRD analysis, the particles were confirmed to be cobalt hydroxide (Co(OH)2) nanoparticles. Further dynamic light scattering (DLS) analysis showed that the average size of the Co(OH)2 nanoparticles is 180 nm. SEM image analysis of the particles revealed that they are spherical mass of feather-like structure, contributing toward increased surface area of the particles. Further, the pharmaceutical potential of the Co(OH)2 nanoparticles was evaluated against eukaryotic cancer and fungal cells. MTT cytotoxicity analysis showed that Co(OH)2 nanoparticles have selective toxicity toward HCT-116 cancer cells with an IC50 value of 25 µg/ml and reduced cytotoxicity to non-cancerous VERO cells with an IC50 value of 200 µg/ml suggesting that the particles possess selective anti-cancerous cytotoxicity. Additionally, the particles demonstrated significant antifungal activity against 5 human fungal pathogens. Conclusions Results of this study conclude that green-synthesized Co(OH)2 nanoparticles using Lantanacamara L possess excellent eukaryotic cytotoxicity against cancer cells and fungal pathogens.

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Green synthesis of Cobalt Nanoparticles using Ethanolic extract of Cadiospermum halicacebium Characterisation and its anticancer applications

Cited by 2 publications

References 0 publications

Medicinal Properties of Cobalt and Copper Nanoparticles Synthesized Using Limonia acidissima Leaf Extract

Medicinal Properties of Cobalt and Copper Nanoparticles Synthesized Using Limonia acidissima Leaf Extract

Anticancer cytotoxicity and antifungal abilities of green-synthesized cobalt hydroxide (Co(OH)2) nanoparticles using Lantana camara L.

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