Green synthesis of cobalt oxide nanoparticles for potential biological applications

Abstract

Cobalt oxide nanoparticles (Co 3 O 4 -Nps) have many applications and now a days the green methods of synthesis of these NPs are preferred over other methods because of associated benefits. In this study, Co 3 O 4 -Nps were synthesized by using leaves extract of Populus ciliata (safaida) and cobalt nitrate hexa hydrate as a source of cobalt. The synthesized NPs were analyzed by different techniques such as fourier transform spectroscopy (FTIR), x-ray diffraction (XRD), transmission electron microscopy (TEM) and scanning electron microscopy (SEM). Antibacterial activities of the synthesized Co 3 O 4 -Nps were evaluated against gram negative and gram positive bacteria and found active against Escherichia coli (E. coli), Klebseilla pneumonia (K. pneumonia), Bacillus subtillus (B.subtillus) and Bacillus lichenifermia (B. lichenifermia). The activity results were analyzed statistically by one-way ANOVA, with 'Dunnett's Multiple Comparison Test'. The maximum mean activity (21.8±0.7) was found for B. subtilis and minimum mean activity (14.0±0.6) was observed for E. coli.

Evaluating the antibacterial effect of cobalt nanoparticles against multi-drug resistant pathogens

“…Furthermore, smaller particles were amalgamated to form clusters of larger size. Other researchers made similar observations about the Co NPs [ 26 – 27 ]. In general, the particle shape and size were uniform with a smooth surface, which could be related to contact with the bacteria to demonstrate increased antibacterial activities [ 27 – 28 ].…”

“…The Co NPs played a role as a potential antiseptic to control the infections by other bacteria such as B. Subtilis and Pseudomonas Sp . [ 10 – 27 ]. It was also suggested that Co NPs were biosafe when cell cytotoxicity tests produced minimal damage to human cells at a nanoparticle concentration of 100 μg/ml [ 13 ].…”

Exploring the therapeutic potential of Hibiscus rosa sinensis synthesized cobalt oxide (Co3O4-NPs) and magnesium oxide nanoparticles (MgO-NPs)

“…Studies have proved that the NPs with smaller size, exhibit enhanced antimicrobial potential due to their direct interaction with microbial membranes ( Rydz et al, 2019 , Kasemets et al, 2019 ). Moreover, green synthesis using plant extracts results in capping of phytochemicals on the NPs surface that can be an important factor in defining antioxidant and enzyme inhibition activity of the synthesized Co 3 O 4 -NPs and MgO-NPs ( Hafeez et al, 2020 , Abinaya et al, 2021 ).…”

Synthesis of Polyaniline Coated Magnesium and Cobalt Oxide Nanoparticles through Eco-Friendly Approach and Their Application as Antifungal Agents

“…XRD technique was also utilized to study the arrangement of green synthesized Co 3 O 4 ( Figure 8 ). Well-defined peaks were not observed in diffraction patterns, which suggests that the obtained nanoparticles do not have a clear crystalline structure [ 44 ]. The XRD peaks with diffraction angle of 2θ are 31.3°, 36.93°, 55.7°, 59.3°, 65.3° are related to the planes of (220), (311), (422), (511), (440) respectively (JCPDS: 42-1467) [ 45 ].…”