Green synthesis of controlled size gold and silver nanoparticles using antioxidant as capping and reducing agent

Khan, Musammir; Ahmad, Fawad; Koivisto, Janne T.; Kellomäki, Minna

doi:10.1016/j.colcom.2020.100322

Cited by 39 publications

(14 citation statements)

References 48 publications

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“…The idea that phenolic compounds and polysaccharides actively participate in AuNPs synthesis, arises because a significant amount of these compounds can be observed from FT-IR. This is supported by different reaction mechanisms explained elsewhere [39,[47][48][49].…”

Section: Characterization Of Gold Nanoparticlessupporting

confidence: 82%

Developing a CNT-SPE Sensing Platform Based on Green Synthesized AuNPs, Using Sargassum sp.

González-Fuentes

Molina

Silva

et al. 2020

Sensors

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Detection and quantification of diverse analytes such as molecules, cells receptor and even particles and nanoparticles, play an important role in biomedical research, particularly in electrochemical sensing platform technologies. In this study, gold nanoparticles (AuNPs) prepared by green synthesis from Sargassum sp. were characterized using ultraviolet-visible (UV-Vis) and Fourier transform-infrared (FT-IR) spectroscopies, X-ray diffraction (XRD), scanning electron microscopy (SEM), dynamic light scattering (DLS) and zeta potential (ζ) obtaining organic capped face-centered cubic 80–100 nm AuNPs with an excellent stability in a wide range of pH. The AuNPs were used to modify a carbon nanotubes-screen printed electrode (CNT-SPE), through the drop-casting method, to assemble a novel portable electrochemical sensing platform for glucose, using a novel combination of components, which together have not been employed. The ability to sense and measure glucose was demonstrated, and its electrochemical fundamentals was studied using cyclic voltammetry (CV). The limits of detection (LOD) and quantification (LOQ) to glucose were 50 μM and 98 μM, respectively, and these were compared to those of other sensing platforms.

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Section: Characterization Of Gold Nanoparticlessupporting

confidence: 82%

Developing a CNT-SPE Sensing Platform Based on Green Synthesized AuNPs, Using Sargassum sp.

González-Fuentes

Molina

Silva

et al. 2020

Sensors

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“…Another strategy would be the functionalization of plant-based AuNPs with synthetic polymers to enhance their targeting efficacy. It has been established that the PEGylation of AuNPs resulted in larger particle size, decreased zeta potential value, and exhibited a completely safe profile for biomedical application [ 209 ]. Nevertheless, the commercialization of AuNPs on a large scale requires careful consideration of the selected biological components.…”

Section: Challenges and Opportunitiesmentioning

confidence: 99%

Application of Green Gold Nanoparticles in Cancer Therapy and Diagnosis

et al. 2022

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Nanoparticles are currently used for cancer theranostics in the clinical field. Among nanoparticles, gold nanoparticles (AuNPs) attract much attention due to their usability and high performance in imaging techniques. The wide availability of biological precursors used in plant-based synthesized AuNPs allows for the development of large-scale production in a greener manner. Conventional cancer therapies, such as surgery and chemotherapy, have significant limitations and frequently fail to produce satisfying results. AuNPs have a prolonged circulation time, allow easy modification with ligands detected via cancer cell surface receptors, and increase uptake through receptor-mediated endocytosis. To exploit these unique features, studies have been carried out on the use of AuNPs as contrast agents for X-ray-based imaging techniques (i.e., computed tomography). As nanocarriers, AuNPs synthesized by nontoxic and biocompatible plants to deliver therapeutic biomolecules could be a significant stride forward in the effective treatment of various cancers. Fluorescent-plant-based markers, including AuNPs, fabricated using Medicago sativa, Olax Scandens, H. ambavilla, and H. lanceolatum, have been used in detecting cancers. Moreover, green synthesized AuNPs using various extracts have been applied for the treatment of different types of solid tumors. However, the cytotoxicity of AuNPs primarily depends on their size, surface reactivity, and surface area. In this review, the benefits of plant-based materials in cancer therapy are firstly explained. Then, considering the valuable position of AuNPs in medicine, the application of AuNPs in cancer therapy and detection is highlighted with an emphasis on limitations faced by the application of such NPs in drug delivery platforms.

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“…Green chemistry has revolutionized the field of material science and nanotechnology to design low‐cost, biocompatible, and biodegradable materials with desired mechanical properties and minimum side product formation. [ 17 ] The use of GA as green capping and reducing agents for the synthesis of Ag and Au NPs is an attractive strategy, [ 18 ] thus avoiding the use of toxic reductants such as hydrazine and sodium borohydride. [ 19 ]…”

Section: Introductionmentioning

confidence: 99%

Injectable and self‐healing biobased composite hydrogels as future anticancer therapeutic biomaterials

2022

Self Cite

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Self-healing composite hydrogels are prepared from sustainable biopolymers by a green chemistry approach and analyzed by physicochemical and mechanical characterization techniques for future injectable anticancer biomaterials. Watersoluble chitosan (WSC) was prepared by grafting polyethylene glycol (PEG), glutamic acid and gallic acid onto the chitosan chain by carbodiimide chemistry. This WSC showed fast gelation (t ≈ < 60 seconds) with benzaldehyde-terminated 4-arm-PEG as a crosslinker through an amine/aldehyde Schiff base reaction.The compression modulus of these gels can be controlled between 6 and 67 kPa, which was dependent on both the crosslinker content as well as the total solid content (T%). It showed injectability and complete self-healing ability at the lower solid content (T = 2%). The hydrogel nanocomposites (HNCs) were synthesized together with gold (Au) and silver (Ag) nanoparticles (NPs) and tested for cytotoxicity using fibroblast cells (WI-38) for 48 hours, which showed good biocompatibility. The in-vitro assay against cancer cells (U87MG) for 48 hours indicated that only the HNCs with incorporated AuNPs were effective agents for cancer cell apoptosis in contrast to pristine gel, pure NPs (Ag and AuNPs) and HCNs with AgNPs. Therefore, these HNCs could be effective chemotherapeutic materials for designing anticancer nanomedicines in the future.

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Green synthesis of controlled size gold and silver nanoparticles using antioxidant as capping and reducing agent

Cited by 39 publications

References 48 publications

Developing a CNT-SPE Sensing Platform Based on Green Synthesized AuNPs, Using Sargassum sp.

Developing a CNT-SPE Sensing Platform Based on Green Synthesized AuNPs, Using Sargassum sp.

Application of Green Gold Nanoparticles in Cancer Therapy and Diagnosis

Injectable and self‐healing biobased composite hydrogels as future anticancer therapeutic biomaterials

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