Green synthesis of copper oxide nanoparticles using sinapic acid: an underpinning step towards antiangiogenic therapy for breast cancer

Preeth, Desingh Raj; Shairam, Manickaraj; Suganya, Natarajan; Roshandel, Hootan; Kartik, R.; Pierre, K. M.; Chatterjee, Suvro; Rajalakshmi, S.

doi:10.1007/s00775-019-01676-z

Cited by 52 publications

(21 citation statements)

References 59 publications

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“…An Ultraviolet-Visible spectrum is used to analyse the Surface Plasmon Resonance (SPR) of nanoparticles. The UV-Visible spectra for CuNPs were in the range of 250 nm-360 nm [38,39]. Likewise, our CuNPs synthesized using Wt R.Br showed absorption peak maxima at 357 nm in the UV-Visible spectra (Figure 3).…”

Section: Uv-visible Spectral Analysismentioning

confidence: 56%

Mixed phytochemicals mediated synthesis of copper nanoparticles for anticancer and larvicidal applications

Rajagopal¹,

Nivetha

Sundar³

et al. 2021

Heliyon

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The synthesis of copper nanoparticles (CuNPs) using Wrightia tinctoria (Wt) R.Br extract is defined in this article as being convenient, environmentally friendly, and non-toxic. UV-visible spectrophotometry, FT-IR, XRD, particle size analyser, SEM-EDAX and TEM methods were used to describe the physicochemical properties of Wt extract mediated synthesized CuNPs (Wt-CuNPs). The Wt-CuNPs synthesized was found to be monodispersed and spherical, with an average size of 15 nm. Gas chromatography and mass spectrometry (GC-MS) research revealed that the Wt R.Br plant extract contains various phytochemical compounds. The properties of Wt-CuNPs were verified by the findings of characterization tests. Via in silico molecular docking experiments with established targets, the underlying mechanisms of cytotoxicity against breast cancer and larvicidal behaviour against Aedes aegypti of Wt-CuNPs were investigated. Interestingly, in vitro cytotoxicity studies showed 50% cell death (IC 50 ) of Wt-CuNPs treated MCF-7 cells and Vero Cells (Kidney epithelial cells) were displayed at 119.23 μg.mL À1 and 898.75 μg.mL À1 , respectively. Also, Wt-CuNPs showed least LC 50 and LC 90 values for larvicidal activity against A. aegypti were of 32.10 μg.mL À1 and 21.70 μg.mL À1 , respectively. Furthermore, Wt-CuNPs is found to be less toxic and biocompatible in haemolytic assays. The findings clearly showed that biosynthesized Wt-CuNPs have been used as a possible anticancer and larvicidal agent, as well as being environmentally friendly.

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Section: Uv-visible Spectral Analysismentioning

confidence: 56%

Mixed phytochemicals mediated synthesis of copper nanoparticles for anticancer and larvicidal applications

Rajagopal¹,

Nivetha

Sundar³

et al. 2021

Heliyon

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“…It is a sensitive colorimetric assay for the determination of the number of survivable cells in cell proliferation and cytotoxicity assays, based on the mitochondrial reduction of the tetrazolium salt by actively growing cells to produce blue water-insoluble formazan crystals. It is well known that CuO can produce strong oxidant OH• as reactive oxygen species (ROS) [36], biomedical and clinical sectors [37] and radical scavenging [38]. In this study, it capped CuO-NPs by QT in order to enhance the efficiency of QT delivery, thus treating cancer cells.…”

Section: Cytotoxicity Assaymentioning

confidence: 99%

Synthesis and characterization of CuO nanoparticles stabilized by quercetin and its application for anti-breast cancer activity

Fakhree¹,

Waheed

Mahmoud

2021

Egypt. J. Chem.

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The main idea in this research used quercetin (QT) as a stabilizing agent to prepare CuO nanoparticle (NPs). QT is a pigment which exists from plants, fruits, and in some medicines. It contains numerous hydroxyl groups, works as a complexing agent and a self-assembly agent. The prepared CuO-NPs were characterized by Fourier transformed infrared (FT-IR), X-ray diffraction (XRD), scanning and transmission electron microscopy (SEM and TEM), and energy-dispersive X-ray analysis (EDX). The structure investigation confirm that the CuO-NPs were polycrystalline nature having a monoclinic crystalline form and showed (111̅ ) and (111) preferential orientations. The estimated particle sizes by XRD, TEM, and SEM ranged from 12.03 to 15.3 nm. Surface analysis displayed that homogeneously distributed CuO-NPs with a spherical shape. On the other hand, synthesized CuO-NPs were tested for anticancer activity on the human breast. The infected cell (MCF-7) uses MTT (3-(4,5-dimethyl-2-triazolyl)-2,5-diphenyl-2tetrazolium bromide) test. The inferred CuO-NPs clarify high anticancer cytotoxicity of the (MCF-7) with an IC50 μM value of 57.6 and 42.8 µg/mL for 24 and 72 h respectively.

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“…Recently Metal Oxide nanoparticles have a challenging base for research as wide varieties of applications attract researchers to explore its properties especially due to their ability to alter the physical, optical and the electronic properties of compounds. Copper oxide nanoparticles gains special interest among the oxides of transition metals because of their efficiency as nanofluids [1], sensors [2], antimicrobial applications [3], catalysis [4], super conductors [5] energy storage systems [6] and as anticancer agent [7]. So far,Copper oxide nanoparticles have been synthesized using chemical, physical, biological and hybrid methods.…”

Section: Introductionmentioning

confidence: 99%

Synthesis and characterization of copper oxide nanoparticles using Brassica oleracea var. italic extract for its antifungal application

Renuga¹,

Jeyasundari²,

Athithan³

et al. 2020

Mater. Res. Express

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Green synthesis has emerged as a reliable, sustainable and ecofriendly protocol for synthesizing a wide range of nanomaterials and hybrid materials. In this paper, we report the synthesis of Copper oxide nanoparticles by a simple biological route using the extract of Brassica oleracea var. italic and copper (II) acetate as the metal precursor. The synthesized copper oxide nanoparticles were characterized using UV-visible spectroscopy, FTIR spectroscopy, FESEM, EDAX, and XRD techniques. UV -Visible analysis shows a characteristic peak around 220 nm for copper oxide nanoparticles. FTIR spectroscopy was used to characterize various capping and reducing agents present in the plant extract responsible for nanoparticle formation. The surface morphology was characterized using FESEM. The EDAX and XRD pattern suggested that prepared copper oxide nanoparticles were highly pure. The average particle size was calculated as 26 nm using the XRD technique. Further, the nanoparticles were found to exhibit the highest antifungal activity against Aspergillus niger and Candida Albicans.

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Green synthesis of copper oxide nanoparticles using sinapic acid: an underpinning step towards antiangiogenic therapy for breast cancer

Cited by 52 publications

References 59 publications

Mixed phytochemicals mediated synthesis of copper nanoparticles for anticancer and larvicidal applications

Mixed phytochemicals mediated synthesis of copper nanoparticles for anticancer and larvicidal applications

Synthesis and characterization of CuO nanoparticles stabilized by quercetin and its application for anti-breast cancer activity

Synthesis and characterization of copper oxide nanoparticles using Brassica oleracea var. italic extract for its antifungal application

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