Green synthesis of gold nanoparticles using brown algae Cystoseira baccata: Its activity in colon cancer cells

González-Ballesteros, Noelia; Prado‐Lopez, Sonia; Rodríguez-González, J. B.; Lastra, Mariano; Rodrı́guez-Argüelles, Marı́a C.

doi:10.1016/j.colsurfb.2017.02.020

Cited by 239 publications

(100 citation statements)

References 49 publications

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“…[ 11 ] In a study conducted with Cystoseira baccata extract, indicated that the OH group may be responsible for the reduction. [ 12 ] In another study, it is mentioned that these functional groups are involved in reduction. [ 6 ]…”

Section: Resultsmentioning

confidence: 99%

Determination of Antimicrobial and Toxic Metal Removal Activities of Plant‐Based Synthesized (Capsicum annuumL. Leaves), Ecofriendly, Gold Nanomaterials

2020

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Nanoparticles are valuable materials with widespread use. The fact that these materials are obtained by biological resources with an environmentally friendly method contributes to the development of studies in this field. Gold nanoparticles (AuNPs) from waste vegetable sources (green leaves of Capsicum annum L.) are economically and easily synthesized. The obtained particles are characterized by UV–vis spectroscopy (UV–vis), Fourier transform infrared spectroscopy (FTIR), X‐ray diffraction (XRD), and scanning electron microscopy (SEM) analysis. The antimicrobial activity of the particles on the pathogenic microorganisms Escherichia coli ATCC 25922, Staphylococcus aureus ATCC 29213, Bacillus subtilis bacteria, and Candida albicans yeast are found to have a significant suppressive effect. The removal activities of eight toxic metals (Pd, Cd, Fe, Ni, Co, Mn, Zn, Pb) in Diyarbakır drinking water and artificially prepared water within different pHs are investigated. Gold nanoparticles synthesized from Capsicum annuum L. leaves are found to be effective in toxic metal removal in water samples.

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Section: Resultsmentioning

confidence: 99%

Determination of Antimicrobial and Toxic Metal Removal Activities of Plant‐Based Synthesized (Capsicum annuumL. Leaves), Ecofriendly, Gold Nanomaterials

2020

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“…The cytotoxic effects of CAO and CAO-AuNPs showed a concentration-dependent cytotoxicity in the range of 12.5–400 μg/mL, and the cell viability was negatively correlated with concentrations of CAO and CAO-AuNPs (as shown in Figure 6B). The IC 50 values of free CAO and CAO-AuNPs against HCT-116 cells holded at 49.9 ± 1.6 μg/mL and 34.4 ± 1.7 μg/mL in 72 h, respectively [38]. Similarly, the IC 50 values of free CAO and CAO-AuNPs to MDA-MB-231 cells were 164.2 ± 1.8 μg/mL and 129.2 ± 1.7 μg/mL, respectively.…”

Section: Resultsmentioning

confidence: 99%

Green Synthesis of Gold Nanoparticles Using Carrageenan Oligosaccharide and Their In Vitro Antitumor Activity

et al. 2018

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Gold nanoparticles (AuNPs) have been widely used in catalysis, photothermal therapy, and targeted drug delivery. Carrageenan oligosaccharide (CAO) derived from marine red algae was used as a reducing and capping agent to obtain AuNPs by an eco-friendly, efficient, and simple synthetic route for the first time. The synthetic conditions of AuNPs were optimized by response surface methodology (RSM), and the CAO-AuNPs obtained were demonstrated to be ellipsoidal, stable and crystalline by means of transmission electron microscopy (TEM), scanning electron microscopy (SEM) and X-ray diffraction (XRD). The CAO-AuNPs showed localized surface plasmon resonance (LSPR) oscillation at about 530 nm with a mean diameter of 35 ± 8 nm. The zeta potential of CAO-AuNPs was around −20 mV, which was related to the negatively charged CAO around AuNPs. The CAO-AuNPs exhibited significant cytotoxic activities to HCT-116 and MDA-MB-231 cells, which could be a promising nanomaterial for drug delivery.

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“…Nanotechnology research has increased in many different areas in the last years, including biomedicine, where nanoparticles have been assessed by their potential to be used against different diseases like cancer. Nanoparticles have been shown to be interesting options in cancer diagnostics and therapeutics, [1][2][3] as an alternative to nonviral delivery systems. 4 Among the different types of nanoparticles, gold nanoparticles (AuNPs) have been demonstrated to inhibit proliferation and induce cell death on different types of cancer cell lines; [1][2][3][5][6][7] moreover, they have been shown to be safe in several biological models, and interesting agents for drug delivery and photothermal therapy against cancer.…”

Section: Introductionmentioning

confidence: 99%

Chitosan gold nanoparticles induce cell death in HeLa and MCF-7 cells through reactive oxygen species production

Martínez‐Torres¹,

Zárate-Triviño²,

Lorenzo-Anota³

et al. 2018

IJN

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BackgroundNanotechnology has gained important interest, especially in the development of new therapies; the application of gold nanoparticles (AuNPs) in the treatment and detection of diseases is a growing trend in this field. As cancer represents a serious health problem around the world, AuNPs are studied as potential drugs or drug carriers for anticancer agents. Recent studies show that AuNPs stabilized with chitosan (CH) possess interesting biological activities, including potential antitumor effects that could be selective to cancer cells.Materials and methodsIn this study, we synthesized sodium citrate-AuNPs and CH-capped AuNPs of 3–10 nm, and analyzed their cytotoxicity in cervical (HeLa) and breast (MCF-7) cancer cells, and in peripheral blood mononuclear cells (PBMCs). Then, we evaluated the clonogenic potential, cell cycle, nuclear alterations, caspase dependence, and reactive oxygen species (ROS) production in HeLa and MCF-7 cells after chitosan gold nanoparticles (CH-AuNPs) exposure.ResultsOur data showed that CH-AuNPs are cytotoxic in a dose-dependent manner in the cancer cell lines tested, while they induce low cytotoxicity in PBMCs. Sodium citrate gold nanoparticles did not show cytotoxic effects. In both HeLa and MCF-7 cell lines, CH-AuNPs inhibit clonogenic potential without inducing cell cycle arrest or nuclear alterations. The cell death mechanism is specific for the type of cancer cell line tested, as it depends on caspase activation in HeLa cells, whereas it is caspase independent in MCF-7 cells. In all cases, ROS production is mandatory for cell death induction by CH-AuNPs, as ROS inhibition with N-acetyl cysteine inhibits cell death.ConclusionOur results show that CH-AuNPs are selective for HeLa and MCF-7 cancer cells, rather than normal PBMCs, and that ROS production seems to be a conserved feature of the cell death mechanism induced by CH-AuNPs. These results improve the knowledge of CH-AuNPs and open the way to the design of new pharmacological strategies using these agents against cancer.

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Green synthesis of gold nanoparticles using brown algae Cystoseira baccata: Its activity in colon cancer cells

Cited by 239 publications

References 49 publications

Determination of Antimicrobial and Toxic Metal Removal Activities of Plant‐Based Synthesized (Capsicum annuumL. Leaves), Ecofriendly, Gold Nanomaterials

Determination of Antimicrobial and Toxic Metal Removal Activities of Plant‐Based Synthesized (Capsicum annuumL. Leaves), Ecofriendly, Gold Nanomaterials

Green Synthesis of Gold Nanoparticles Using Carrageenan Oligosaccharide and Their In Vitro Antitumor Activity

Chitosan gold nanoparticles induce cell death in HeLa and MCF-7 cells through reactive oxygen species production

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