Green Synthesis of Silica Nanoparticles From Olive Residue and Investigation of Their Anticancer Potential

Rezaeian, Masoud; Afjoul, Homa; Shamloo, Amir; Maleki, Ali; Afjoul, Neda

doi:10.2217/nnm-2021-0040

Cited by 22 publications

(3 citation statements)

References 54 publications

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“…The enhanced cytobiocompatibility of green synthesized OE-Ag NPs with hMSC cells and 293T cells might be resulted because of the existence of biological active and biocompatible secondary metabolites of the plant leaf extract. The similar finding on the biocompatible nature of plant leaf extract and enhanced cytobiocompatibility of the nanoparticles after the inclusion of secondary metabolites on their surface were also reported by [58,59].…”

Section: Biocompatibility Analysissupporting

confidence: 85%

Green Synthesis of Silver Nanoparticles Using Olea europaea Leaf Extract for Their Enhanced Antibacterial, Antioxidant, Cytotoxic and Biocompatibility Applications

Sellami

Khan

Ahmad

et al. 2021

IJMS

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Herein, we report the green synthesis of silver nanoparticles (OE-Ag NPs) by ecofriendly green processes using biological molecules of Olea europaea leaf extract. Green synthesized OE-Ag NPs were successfully characterized using different spectroscopic techniques. Antibacterial activity of OE-Ag NPs was assessed against four different bacteriological strains using the dilution serial method. The cytotoxic potential was determined against MCF-7 carcinoma cells using MTT assay in terms of cell viability percentage. Antioxidant properties were evaluated in terms of 2,2-diphenyl-1-picrylhydrazyl (DPPH) free radical scavenging. Biocompatibility was further examined by incubating the synthesized NPs with hMSC cells for 24 h. The results were demonstrated that synthesized OE-Ag NPs presented excellent log10 reduction in the growth of all the tested bacterial strains, which as statistically equivalent (p > 0.05) to the standard antibiotic drug. Moreover, they also demonstrated excellent cytotoxic efficacy against the MCF-7 carcinoma cells compared to plant lead extract and Com-Ag NPs. Green synthesized OE-Ag NPs appeared more biocompatible to hMSC and 293T cells compared to Com-Ag NPs. Excellent biological results of the OE-Ag NPs might be attributed to the synergetic effect of NPs’ properties and the adsorbed secondary metabolites of plant leaf extract. Hence, this study suggests that synthesized OE-Ag NPs can be a potential contender for their various biological and nutraceutical applications. Moreover, this study will open a new avenue to produce biocompatible nanoparticles with additional biological functionalities from the plants.

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Section: Biocompatibility Analysissupporting

confidence: 85%

Green Synthesis of Silver Nanoparticles Using Olea europaea Leaf Extract for Their Enhanced Antibacterial, Antioxidant, Cytotoxic and Biocompatibility Applications

Sellami

Khan

Ahmad

et al. 2021

IJMS

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“…Some of these works evaluated the mixing efficiency and merging of microparticles into a magnetic platform [ 29 ]. However, because these platforms provide manipulation conditions for a single droplet, they are not suitable for processes such as drug screening, which require high-throughput droplet formation [ 30 ]. Magnetic stirring inside the droplet is an alternative way to enhance the mixing.…”

Section: Introductionmentioning

confidence: 99%

The Effect of Non-Uniform Magnetic Field on the Efficiency of Mixing in Droplet-Based Microfluidics: A Numerical Investigation

et al. 2022

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Achieving high efficiency and throughput in droplet-based mixing over a small characteristic length, such as microfluidic channels, is one of the crucial parameters in Lab-on-a-Chip (LOC) applications. One solution to achieve efficient mixing is to use active mixers in which an external power source is utilized to mix two fluids. One of these active methods is magnetic micromixers using ferrofluid. In this technique, magnetic nanoparticles are used to make one phase responsive to magnetic force, and then by applying a magnetic field, two fluid phases, one of which is magneto-responsive, will sufficiently mix. In this study, we investigated the effect of the magnetic field’s characteristics on the efficiency of the mixing process inside droplets. When different concentrations of ferrofluids are affected by a constant magnetic field, there is no significant change in mixing efficiency. As the magnetic field intensifies, the magnetic force makes the circulation flow inside the droplet asymmetric, leading to chaotic advection, which creates a flow that increases the mixing efficiency. The results show that the use of magnetic fields is an effective method to enhance the mixing efficiency within droplets, and the efficiency of mixing increases from 65.4 to 86.1% by increasing the magnetic field intensity from 0 to 90 mT. Besides that, the effect of ferrofluid’s concentration on the mixing efficiency is studied. It is shown that when the concentration of the ferrofluid changes from 0 to 0.6 mol/m3, the mixing efficiency increases considerably. It is also shown that by changing the intensity of the magnetic field, the mixing efficiency increases by about 11%.

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“…Immobilization of bioactive and compatible biomolecules on the surface of LEVB-Ag NAPs may have contributed to their better cytobiocompatibility with normal cell lines. Another study found that immobilizing physiologically active phytoconstituents from plant extracts on the surface of silica NAPs improved their cytobiocompatibility ( Rezaeian et al, 2021 ).…”

Section: Resultsmentioning

confidence: 99%

Viola betonicifolia-Mediated Biosynthesis of Silver Nanoparticles for Improved Biomedical Applications

et al. 2022

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We report the biosynthesis of silver (Ag) nanoparticles (NAPs) (LEVB-Ag NAPs) by an environmentally friendly green synthesis approach using the phytoconstituents of Viola betonicifolia leaf extract. The spectroscopic techniques were employed to characterize biosynthesized LEVB-Ag NAPs successfully. Biosynthesized LEVB-Ag NAPs were assessed for antibacterial and antimycotic activities against bacterium and mycological strains (H. pylori, S. epidermidis, C. tropicalis, and T. rubrum) using the serial dilution method. They were also evaluated for their biofilm inhibiting potential against both bacterial and fungi species. They were further assessed for the cytobiocompatible potential with two normal cell lines (293T and hMSC). The results demonstrate that the biosynthesized LEVB-Ag NAPs showed superior log10 reduction in bacterial and fungal growth and presented more than 99.50% killing efficiency. Moreover, biosynthesized LEVB-Ag NAPs excellently inhibited the biofilm formation of bacterial (Gram-positive and Gram-negative) and mycological strains and presented more than 80% biofilm inhibiting percentage compared to both plant extract and CHE-Ag NAPs. They further presented good cytobiocompatibility in vitro with 293T and hMSC cells compared to CHE-Ag NAPs. Biosynthesized LEVB-Ag NAPs presented superior antibacterial, antimycotic, biofilm inhibition, and cytobiocompatible results that might be attributed to the synergistic effect of the NAPs’ physiochemical properties and the immobilized phytoconstituents from plant leaf extract on their surface. Hence, biosynthesized LEVB-Ag NAPs may be a promising contender for a variety of therapeutic applications.

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Green Synthesis of Silica Nanoparticles From Olive Residue and Investigation of Their Anticancer Potential

Cited by 22 publications

References 54 publications

Green Synthesis of Silver Nanoparticles Using Olea europaea Leaf Extract for Their Enhanced Antibacterial, Antioxidant, Cytotoxic and Biocompatibility Applications

Green Synthesis of Silver Nanoparticles Using Olea europaea Leaf Extract for Their Enhanced Antibacterial, Antioxidant, Cytotoxic and Biocompatibility Applications

The Effect of Non-Uniform Magnetic Field on the Efficiency of Mixing in Droplet-Based Microfluidics: A Numerical Investigation

Viola betonicifolia-Mediated Biosynthesis of Silver Nanoparticles for Improved Biomedical Applications

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