Green synthesized doxorubicin loaded zinc oxide nanoparticles regulates the Bax and Bcl-2 expression in breast and colon carcinoma

Vimala, Karuppaiya; Kannan, R.; Paulpandi, Manickam; Vengatesan, Srinivasan; Kannan, Soundarapandian

doi:10.1016/j.procbio.2013.10.007

Cited by 227 publications

(93 citation statements)

References 45 publications

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“…While increasing concentration by 50 μM/mL cytotoxicity increases in 48 h (Figure c and d). Indeed, our results provide conclusive evidence for cytotoxic effect of synthesized compounds against breast cancer MCF‐7 cell line compared with HBL‐100 normal breast cell line …”

Section: Resultssupporting

confidence: 62%

Synthesis, Biological Evaluation and Molecular Docking of Novel Curcumin Derivatives as Bcl‐2 Inhibitors Targeting Human Breast Cancer MCF‐7 Cells

2017

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An efficient one‐pot multicomponent double Michael addition strategy was developed for the synthesis of novel curcumin derivatives using 1,4‐diazabicyclo [2.2.2] octane (DABCO) as the catalyst. Selected compounds (E)‐4,4′′,5′‐trihydroxy‐6′‐(3‐(4‐hydroxy‐3‐methoxyphenyl)acryloyl)‐3,3′′‐dimethoxy‐3′,4′‐dihydro‐[1, 1′:3′, 1′′‐terphenyl]‐2′,2′(1′H)‐dicarbonitrile (4 k) and (E)‐ethyl 2′‐cyano‐4′′,5′‐dihydroxy‐6′‐(3‐(4‐hydroxy‐3‐methoxyphenyl)acryloyl)‐3′′‐methoxy‐4‐methyl‐1′,2′,3′,4′‐tetrahydro‐[1, 1′:3′, 1′′‐terphenyl]‐2′‐carboxylate (6 j) were evaluated for their in‐vitro anticancer activities against human breast cancer cells (MCF‐7) and human normal breast cells (HBL 100) and found to show effective cytotoxicity on MCF‐7 cells and less cytotoxicity on HBL 100 cells than simple curcumin. In addition, molecular docking studies helped to rationalize anti‐apoptotic Bcl‐2 binding of all the synthesized compounds and revealed that the docking of compounds 4 k and 6 j with Bcl‐2 was more potent compared to curcumin.

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Section: Resultssupporting

confidence: 62%

Synthesis, Biological Evaluation and Molecular Docking of Novel Curcumin Derivatives as Bcl‐2 Inhibitors Targeting Human Breast Cancer MCF‐7 Cells

2017

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“…SEM micrographs of green synthesized ZnO nanorods showed main particle size of 100 nm [30]. Earlier SEM reports showed the synthesis of spherical and rod-like shapes with sizes of 50-60 nm [31]. In the EDX spectrum, Zn atom exhibited strong signal, along with Zn atom the small signal was exhibited from Ca, K and O atoms respectively, which may be linked to the presence of carbohydrates and proteins present in the plant extract [27].…”

Section: Discussionmentioning

confidence: 80%

“…TEM images of the synthesized ZnO showed the center of a tetrapod to the tip of a rod, where the thickness of the rod was uniform (68 nm). In addition, rod-like ZnO had similar characteristics with that of tetrapod-like ZnO [31]. TEM analysis of green Ag nanoparticles synthesized using M. fragrans seed extract were predominantly spherical in shape, distributed with a size range of 7-20 nm [28].…”

Section: Discussionmentioning

confidence: 99%

Toxicity on Dengue Mosquito Vectors Through Myristica fragrans-Synthesized Zinc Oxide Nanorods, and Their Cytotoxic Effects on Liver Cancer Cells (HepG2)

et al. 2016

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Dengue is an arbovirus mainly vectored by Aedes mosquitoes. Its prevention and control depends to effective vector control measures. Cancer causes millions of death every year. Most of the anticancer drugs have high toxicity and low specificity of action, leading to systemic toxicity and severe side effects. Thus, the development of effective tools is a priority. We fabricated zinc oxide nanoparticles using the Myristica fragrans extract as a reducing and stabilizing agent. Nanoparticles were studied using UV-vis spectrophotometry, Fourier transform infrared spectroscopy, X-ray diffraction, zeta potential, dynamic light scattering, energy dispersive X-ray analysis, field emission scanning electron microscopy and transmission electron microscopy. ZnO nanorods were highly effective against A. aegypti young instars, with LC 50 ranging from 3.44 (larva I) to 14.63 ppm (pupa). Nanorods showed adult LC 50 of 15.004 ppm. ZnO nanorods exhibited dose-dependent cytotoxicity against human hepato-cancer cells (HepG2). After 48 and 24 h of incubation, the IC 50 were 20 and 22 lg/ml, respectively. Nanorods triggered the induction of apoptosis. Overall, this study highlights that the possibility to employ M. fragrans-synthesized ZnO nanorods in mosquito control, as well as in the development of novel chemotherapeutic agents with reduced systemic toxicity.

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“…Dai et al 74 reported stable NPs from ginsenoside and anticancer drugs, with enhanced antitumor effects in vitro and in vivo compared to free drugs. Research by Vimala et al 75 has indicated the potential of zinc oxide (ZnO) NPs as a carrier for DOX, which focuses on the significance of progressing novel green chemistry-based strategies for introducing safe sources of NPs.…”

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confidence: 99%

A review of drug delivery systems based on nanotechnology and green chemistry: green nanomedicine

Jahangirian

Lemraski

Webster

et al. 2017

IJN

449

216

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This review discusses the impact of green and environmentally safe chemistry on the field of nanotechnology-driven drug delivery in a new field termed “green nanomedicine”. Studies have shown that among many examples of green nanotechnology-driven drug delivery systems, those receiving the greatest amount of attention include nanometal particles, polymers, and biological materials. Furthermore, green nanodrug delivery systems based on environmentally safe chemical reactions or using natural biomaterials (such as plant extracts and microorganisms) are now producing innovative materials revolutionizing the field. In this review, the use of green chemistry design, synthesis, and application principles and eco-friendly synthesis techniques with low side effects are discussed. The review ends with a description of key future efforts that must ensue for this field to continue to grow.

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Green synthesized doxorubicin loaded zinc oxide nanoparticles regulates the Bax and Bcl-2 expression in breast and colon carcinoma

Cited by 227 publications

References 45 publications

Synthesis, Biological Evaluation and Molecular Docking of Novel Curcumin Derivatives as Bcl‐2 Inhibitors Targeting Human Breast Cancer MCF‐7 Cells

Synthesis, Biological Evaluation and Molecular Docking of Novel Curcumin Derivatives as Bcl‐2 Inhibitors Targeting Human Breast Cancer MCF‐7 Cells

Toxicity on Dengue Mosquito Vectors Through Myristica fragrans-Synthesized Zinc Oxide Nanorods, and Their Cytotoxic Effects on Liver Cancer Cells (HepG2)

A review of drug delivery systems based on nanotechnology and green chemistry: green nanomedicine

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