Green tea and cancer chemoprevention

Suganuma, Masami; Okabe, Sachiko; Sueoka, Naoko; Sueoka, Eisaburo; Matsuyama, Satoru; Imai, Kazue; Nakachi, Kei; Fujiki, Hirota

doi:10.1016/s1383-5742(99)00059-9

Cited by 182 publications

(87 citation statements)

References 12 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…(7 -10). Epidemiologic studies also suggest that incidence of breast cancer in regions where green tea is consumed in large quantities, including China and Japan, is much lower than in Western countries (11). Furthermore, several lines of evidence from experimental studies have shown that GTP induced growth inhibitory effects on cancerous cells but does not adversely affect normal cells (12).…”

Section: Introductionmentioning

confidence: 99%

Growth Inhibitory and Antimetastatic Effect of Green Tea Polyphenols on Metastasis-Specific Mouse Mammary Carcinoma 4T1 Cells In vitro and In vivo Systems

Baliga¹,

Meleth²,

Katiyar

2005

Clinical Cancer Research

154

View full text Add to dashboard Cite

Purpose: Breast cancer is the second leading cause of cancer-related deaths among females. Dietary habits may have a role in breast cancer risk and prevention as well. Here, we examined the effect of green tea polyphenols (GTP) on growth and metastasis of highly metastatic mouse mammary carcinoma 4T1 cells in vitro and in vivo systems.Experimental Design: 4T1 cells were treated with (À À À) -epigallocatechin-3-gallate (EGCG), and the effect was determined on cellular proliferation, induction of apoptosis, proapoptosis, and antiapoptotic proteins of Bcl-2 family, and caspase 3 and poly(ADP-ribose) polymerase activation following 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide, flow cytometry, and Western blot analysis. Anticarcinogenic and antimetastatic effect of GTP in 4T1 cells was assessed in immunocompetent BALB/c mice.Results: Treatment of 4T1 cells with EGCG resulted in inhibition of cell proliferation, induction of apoptosis in doseand time-dependent manner. The increase in apoptosis was accompanied with decrease in the protein expression of Bcl-2 concomitantly increase in Bax, cytochrome c release, Apaf-1, and cleavage of caspase 3 and PARP proteins. Treatment of EGCG-rich GTP in drinking water to 4T1 cells bearing BALB/c mice resulted in reduction of tumor growth accompanied with increase in Bax/Bcl-2 ratio, reduction in proliferating cell nuclear antigen and activation of caspase 3 in tumors. Metastasis of tumor cells to lungs was inhibited and survival period of animals was increased after green tea treatment.Conclusion: This study suggests that GTP have the ability to prevent the development of breast cancer and its metastasis; however, further in vivo studies are required to identify the molecular targets.

show abstract

Section: Introductionmentioning

confidence: 99%

Growth Inhibitory and Antimetastatic Effect of Green Tea Polyphenols on Metastasis-Specific Mouse Mammary Carcinoma 4T1 Cells In vitro and In vivo Systems

Baliga¹,

Meleth²,

Katiyar

2005

Clinical Cancer Research

154

View full text Add to dashboard Cite

show abstract

“…[22][23][24] The tea component theanine can enhance the antitumor activity of adriamycin and doxorubicin against ovarian sarcoma. 10,11 Progress has been made recently in understanding the molecular mechanisms of cancer chemo-prevention by tea and tea polyphenols.…”

Section: Discussionmentioning

confidence: 99%

Green tea consumption enhances survival of epithelial ovarian cancer

Zhang

Lee

Binns

et al. 2004

Intl Journal of Cancer

View full text Add to dashboard Cite

Our study investigates whether tea consumption can enhance the survival of patients with epithelial ovarian cancer, a prospective cohort study was conducted in Hangzhou, China. The cohort comprised 254 patients recruited during 1999 -2000 with histopathologically confirmed epithelial ovarian cancer and was followed up for a minimum of 3 years. Two hundred forty four (96.1%) of the cohort or their close relatives were traced. The variables examined included their survival time and the frequency and quantity of tea consumed post-diagnosis. The actual number of deaths was obtained and Cox proportional hazards models were used to obtain hazard ratios and associated 95% confidence intervals (CI), adjusting for age at diagnosis, locality, BMI, parity,

show abstract

“…Drinking tea, especially green tea, is associated with a lower incidence of human cancer (1,2). Subsequent studies demonstrated that certain fractions of green tea, among them (Ϫ)-epigallocatechin-3-gallate (EGCG), 34 promote apoptosis and cell cycle arrest of transformed cells (3)(4)(5).…”

mentioning

confidence: 99%

Green Tea Epigallocatechin-3-Gallate Mediates T Cellular NF-κB Inhibition and Exerts Neuroprotection in Autoimmune Encephalomyelitis

Aktaş

Prozorovski

Smorodchenko

et al. 2004

The Journal of Immunology

301

188

View full text Add to dashboard Cite

Recent studies in multiple sclerosis and its animal model, experimental autoimmune encephalomyelitis (EAE), point to the fact that even in the early phase of inflammation, neuronal pathology plays a pivotal role in the sustained disability of affected individuals. We show that the major green tea constituent, (−)-epigallocatechin-3-gallate (EGCG), dramatically suppresses EAE induced by proteolipid protein 139–151. EGCG reduced clinical severity when given at initiation or after the onset of EAE by both limiting brain inflammation and reducing neuronal damage. In orally treated mice, we found abrogated proliferation and TNF-α production of encephalitogenic T cells. In human myelin-specific CD4+ T cells, cell cycle arrest was induced, down-regulating the cyclin-dependent kinase 4. Interference with both T cell growth and effector function was mediated by blockade of the catalytic activities of the 20S/26S proteasome complex, resulting in intracellular accumulation of IκB-α and subsequent inhibition of NF-κB activation. Because its structure implicates additional antioxidative properties, EGCG was capable of protecting against neuronal injury in living brain tissue induced by N-methyl-d-aspartate or TRAIL and of directly blocking the formation of neurotoxic reactive oxygen species in neurons. Thus, a natural green tea constituent may open up a new therapeutic avenue for young disabled adults with inflammatory brain disease by combining, on one hand, anti-inflammatory and, on the other hand, neuroprotective capacities.

show abstract

Green tea and cancer chemoprevention

Cited by 182 publications

References 12 publications

Growth Inhibitory and Antimetastatic Effect of Green Tea Polyphenols on Metastasis-Specific Mouse Mammary Carcinoma 4T1 Cells In vitro and In vivo Systems

Growth Inhibitory and Antimetastatic Effect of Green Tea Polyphenols on Metastasis-Specific Mouse Mammary Carcinoma 4T1 Cells In vitro and In vivo Systems

Green tea consumption enhances survival of epithelial ovarian cancer

Green Tea Epigallocatechin-3-Gallate Mediates T Cellular NF-κB Inhibition and Exerts Neuroprotection in Autoimmune Encephalomyelitis

Contact Info

Product

Resources

About