Green tea catechins prevent low-density lipoprotein oxidation via their accumulation in low-density lipoprotein particles in humans

Suzuki-Sugihara, Norie; Kishimoto, Yoshimi; Saita, Emi; Taguchi, Chie; Kobayashi, Makoto; Ichitani, Masaki; Ukawa, Yuuichi; Sagesaka, Yuko M.; Suzuki, Eiji; Kondo, Kazuo

doi:10.1016/j.nutres.2015.10.012

Cited by 73 publications

(41 citation statements)

References 42 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…EGCG induces HO-1 expression in EC exposed to H 2 O 2 through activation of Akt and Nrf2, thereby diminishing the effects of oxidative stress [247]. Many other catechins exert antioxidant properties expressed as prevention of in vitro LDL oxidation and in humans [248]. Studies on green tea found that its administration (2% in water) to diabetic rats increased serum PON1 activity [249].…”

Section: Isoflavonesmentioning

confidence: 99%

Phenolic Compounds Exerting Lipid-Regulatory, Anti-Inflammatory and Epigenetic Effects as Complementary Treatments in Cardiovascular Diseases

et al. 2020

View full text Add to dashboard Cite

Atherosclerosis is the main process behind cardiovascular diseases (CVD), maladies which continue to be responsible for up to 70% of death worldwide. Despite the ongoing development of new and potent drugs, their incomplete efficacy, partial intolerance and numerous side effects make the search for new alternatives worthwhile. The focus of the scientific world turned to the potential of natural active compounds to prevent and treat CVD. Essential for effective prevention or treatment based on phytochemicals is to know their mechanisms of action according to their bioavailability and dosage. The present review is focused on the latest data about phenolic compounds and aims to collect and correlate the reliable existing knowledge concerning their molecular mechanisms of action to counteract important risk factors that contribute to the initiation and development of atherosclerosis: dyslipidemia, and oxidative and inflammatory-stress. The selection of phenolic compounds was made to prove their multiple benefic effects and endorse them as CVD remedies, complementary to allopathic drugs. The review also highlights some aspects that still need clear scientific explanations and draws up some new molecular approaches to validate phenolic compounds for CVD complementary therapy in the near future.In the last decade the scientific researchers turned their attention to phytochemicals, as effective, safe and low-cost natural bioactive compounds for CVD treatment.Dyslipidemia consists of increased blood concentrations of total cholesterol (TC), low density lipoproteins-cholesterol (LDL-C) and/or triglycerides (TG), and decreased high density lipoproteins-cholesterol (HDL-C) [6]. The lipid metabolism is complex and the candidate mechanisms that could generate dyslipidemia include: (i) excessive dietary lipid absorption in the small intestine; (ii) packing of exogenous lipids with cholesterol and fatty acids produced de novo in the liver and their secretion as very low density lipoproteins (VLDL); (iii) hydrolysis of TG from VLDL by lipases and their conversion into LDL, which are taken up by the peripheral tissues through LDL receptor (LDL-R) and scavenger receptors; (iv) diminished production of HDL by the liver and small intestine, thereby decreasing reverse cholesterol transport (RCT) from the peripheral tissues to the liver; (v) lowered excess cholesterol excretion from the liver into gallbladder or to the intestinal lumen through the ATP-binding cassette G5 and G8 transporters (ABCG5/G8) that facilitate trans-intestinal cholesterol efflux (TICE). Dyslipidemia is associated with the accumulation of LDL in the sub-endothelium of the artery wall. At this site, LDL undergoes oxidative modifications (oxLDL) that trigger inflammatory responses, and is taken up by the monocyte-derived macrophages infiltrated in the sub-endothelium which thus become lipid-loaded foam cells, the hallmark of atheroma development [7]. Until now, the most effective lipid-lowering treatment for hyperlipidemic patients was the statin therapy. But recen...

show abstract

Section: Isoflavonesmentioning

confidence: 99%

Phenolic Compounds Exerting Lipid-Regulatory, Anti-Inflammatory and Epigenetic Effects as Complementary Treatments in Cardiovascular Diseases

et al. 2020

View full text Add to dashboard Cite

show abstract

“…In addition, a recent study found that green tea catechins are incorporated into LDL particles, and are then able to reduce the oxidation of LDL. Catechins prevent LDL oxidation via radical-trapping abilities and act as hydrogen donors to α-tocopherol radicals [105].…”

Section: Lipid Metabolismmentioning

confidence: 99%

An Update on the Health Benefits of Green Tea

Reygaert

2017

Beverages

View full text Add to dashboard Cite

Abstract:Green tea, which is produced from the leaves of the Camellia sinensis plant, is one of the most popular beverages worldwide. Over the past 30 years or more, scientists have studied this plant in respect to potential health benefits. Research has shown that the main components of green tea that are associated with health benefits are the catechins. The four main catechins found in green tea are: (−)-epicatechin (EC), (−)-epicatechin-3-gallate (ECG), (−)-epigallocatechin (EGC), and (−)-epigallocatechin-3-gallate (EGCG). Of these four, EGCG is present in the largest quantity, and so has been used in much of the research. Among the health benefits of green tea are: anticarcinogenic, anti-inflammatory, antimicrobial, and antioxidant properties, and benefits in cardiovascular disease and oral health. Research has been carried out using various animal models and cells lines, and is now more and more being carried out in humans. This type of research will help us to better understand the direct benefits of green tea. This review will focus primarily on research conducted using human subjects to investigate the health benefits of green tea.

show abstract

“…In recent years, the damage degree of DNA induced by reactive oxygen species (ROS)—such as hydroxyl radicals (·OH), hydrogen peroxide (H 2 O 2 ), and superoxide (O 2 − )—or the capacity of antioxidants for scavenging ROS have been widely investigated in the food technology and human health fields [ 9 , 10 ]. Several research papers indicate that oxidized low-density lipoprotein (LDL) within the arterial wall promotes the development of atherosclerosis [ 11 ]. Protection against LDL oxidation is an effective strategy to prevent atherosclerosis [ 11 , 12 ], and growing evidence from epidemiologic studies has shown that dietary antioxidants contribute to the prevention of coronary heart disease [ 11 , 13 ].…”

Section: Introductionmentioning

confidence: 99%

Bovine Colostrum Whey Protein Hydrolysate Inhibits Cell DNA Damage and LDL Oxidation In Vitro

et al. 2017

View full text Add to dashboard Cite

Whey protein isolated from bovine colostrums collected on the second day postpartum was two-stage hydrolyzed by alcalase and flavourzyme. The whey hydrolysates were finally fractionated by ultrafiltration (UF) with a 10 kDa molecular weight (MW) cutoff membrane and subsequently used to evaluate the effect of whey protein hydrolysis on inhibition of DNA oxidative damage and low-density lipoprotein (LDL) oxidation in vitro. Results showed that whey hydrolysis exhibited not only higher inhibitory activities of oxidative damage of deoxyribose but also an inhibitory effect on the breakdown of supercoiled DNA into open circular DNA and linear DNA. The quantities of 8-hydroxy-2′-deoxyguanosine (8-OH-2′-dG) formed with the addition of whey hydrolysate protein, the hydrolysate fraction of MW >10 kDa, and the hydrolysate fraction of MW <10 kDa were 0.25, 0.06, and 0.09 μg/mL, respectively. The lag time of conjugated diene formation of the control sample, which was only combined with cupric ions and LDL, was 90 min. The samples added with the hydrolysate fractions exhibited higher inhibitory activity on LDL oxidation. The whey hydrolysate fractions extended the lag time of conjugated diene formation to 270 min. The lag time of the whey hydrolysate fractions was 3 times that of the control.

show abstract

Green tea catechins prevent low-density lipoprotein oxidation via their accumulation in low-density lipoprotein particles in humans

Cited by 73 publications

References 42 publications

Phenolic Compounds Exerting Lipid-Regulatory, Anti-Inflammatory and Epigenetic Effects as Complementary Treatments in Cardiovascular Diseases

Phenolic Compounds Exerting Lipid-Regulatory, Anti-Inflammatory and Epigenetic Effects as Complementary Treatments in Cardiovascular Diseases

An Update on the Health Benefits of Green Tea

Bovine Colostrum Whey Protein Hydrolysate Inhibits Cell DNA Damage and LDL Oxidation In Vitro

Contact Info

Product

Resources

About