Green tea (-)-epigallocatechin-3-gallate counteracts daytime overeating induced by high-fat diet in mice

Li, Hongyu; Kek, Huiling Calvina; Lim, Joy; Gelling, Richard W.; Han, Weiping

doi:10.1002/mnfr.201600162

Cited by 37 publications

(20 citation statements)

References 42 publications

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“…Diminished insulin signaling in the brain has an orexigenic effect, which results in body weight gain associated with peripheral insulin resistance (66). Furthermore, a high-fat diet was reported to impair the brain reward system and propagate a vicious cycle of repetitive eating (67). In this study, the effect of HFFD on the expression of appetite-regulating genes was in agreement with previous reports, and EGCG was found to attenuate this effect.…”

Section: Discussionsupporting

confidence: 92%

EGCG ameliorates high‐fat– and high‐fructose‐induced cognitive defects by regulating the IRS/AKT and ERK/CREB/BDNF signaling pathways in the CNS

Fan

et al. 2017

FASEB j.

114

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Obesity, which is caused by an energy imbalance between calorie intake and consumption, has become a major international health burden. Obesity increases the risk of insulin resistance and age-related cognitive decline, accompanied by peripheral inflammation. (-)-Epigallocatechin-3-gallate (EGCG), the major polyphenol in green tea, possesses antioxidant, anti-inflammatory, and cardioprotective activities; however, few reports have focused on its potential effect on cognitive disorders. In this study, our goal was to investigate the protective effects of EGCG treatment on insulin resistance and memory impairment induced by a high-fat and high-fructose diet (HFFD). We randomly assigned 3-mo-old C57BL/6J mice to 3 groups with different diets: control group, HFFD group, and HFFD plus EGCG group. Memory loss was assessed by using the Morris water maze test, during which EGCG was observed to prevent HFFD-elicited memory impairment and neuronal loss. Consistent with these results, EGCG attenuated HFFD-induced neuronal damage. Of note, EGCG significantly ameliorated insulin resistance and cognitive disorder by up-regulating the insulin receptor substrate-1 (IRS-1)/AKT and ERK/cAMP response element binding protein (CREB)/brain-derived neurotrophic factor (BDNF) signaling pathways. Long-term HFFD-triggered neuroinflammation was restored by EGCG supplementation by inhibiting the MAPK and NF-κB pathways, as well as the expression of inflammatory mediators, such as TNF-α. EGCG also reversed high glucose and glucosamine-induced insulin resistance in SH-SY5Y neuronal cells by improving the oxidized cellular status and mitochondrial function. To our knowledge, this study is the first to provide compelling evidence that the nutritional compound EGCG has the potential to ameliorate HFFD-triggered learning and memory loss.-Mi, Y., Qi, G., Fan, R., Qiao, Q., Sun, Y., Gao, Y., Liu, X. EGCG ameliorates high-fat- and high-fructose-induced cognitive defects by regulating the IRS/AKT and ERK/CREB/BDNF signaling pathways in the CNS.

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Section: Discussionsupporting

confidence: 92%

EGCG ameliorates high‐fat– and high‐fructose‐induced cognitive defects by regulating the IRS/AKT and ERK/CREB/BDNF signaling pathways in the CNS

Fan

et al. 2017

FASEB j.

114

View full text Add to dashboard Cite

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“…Polyphenols, such as proanthocyanidins, resveratrol, and nobiletin have drawn increasing attention as their clock‐enhancing properties. A recent research exhibited that supplementary of EGCG altered diurnally oscillating expression pattern of key appetite‐regulating genes as well as key circadian genes like Clock and Bmal1 in hypothalamus of mice . Furthermore, our previous studies have revealed that EGCG, the most abundant catechin in green tea, may ameliorate HFFD‐induced obesity and metabolic disorders via circadian clock related mechanisms .…”

Section: Discussionmentioning

confidence: 96%

(‐)‐Epigallocatechin‐3‐gallate Ameliorates Insulin Resistance and Mitochondrial Dysfunction in HepG2 Cells: Involvement of Bmal1

Gao

et al. 2017

Molecular Nutrition Food Res

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“…Huang et al [40] showed that Jiao-Tai-Wan could increase the expression levels of circadian proteins CRY1 and CRY2 in hypothalamus of obesity-resistant rats with chronic partial sleep deprivation, which was associated with improvement in inflammation. The benefits of green tea (-)-epigallocatechin-3-gallate on food intake were confirmed to be associated with the expression of Clock and Bmal1 in hypothalamus of high-fat fed mice [41]. However, research exploring the association between the protective effects of genistein intake against metabolic disorders and the circadian clock is scarce.…”

Section: Discussionmentioning

confidence: 99%

Dietary Genistein Could Modulate Hypothalamic Circadian Entrainment, Reduce Body Weight, and Improve Glucose and Lipid Metabolism in Female Mice

Zhou

Xiao

Zhang

et al. 2019

International Journal of Endocrinology

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Genistein has beneficial effects on metabolic disorders. However, the specific mechanism is not clearly understood. In light of the significant role of the hypothalamus in energy and metabolic homeostasis, this study was designed to explore whether dietary genistein intake could mitigate the harmful effects of a high-fat diet on glucose and lipid metabolism and whether any alterations caused by dietary genistein were associated with hypothalamic gene expression profiles. C57BL/6 female mice were fed a high-fat diet without genistein (HF), a high-fat diet with genistein (HFG), or a normal control diet (CON) for 8 weeks. Body weight and energy intake were assessed. At the end of the study, glucose tolerance and serum levels of insulin and lipids were analyzed. Hypothalamic tissue was collected for whole transcriptome sequencing and reverse transcription quantitative PCR (RT-qPCR) validation. Energy intake and body weight were significantly reduced in the mice of the HFG group compared with those of the HF group. Mice fed the HFG diet had improved glucose tolerance and decreased serum triacylglycerol, free fatty acids, and low-density lipoprotein cholesterol compared with those fed the HF diet. The HFG diet also modulated gene expression in the hypothalamus; the most abundant genes were enriched in the circadian entrainment pathway. Dietary genistein intake could reduce body weight, improve glucose and lipid metabolism, and regulate hypothalamic circadian entrainment. The ability of genistein intake to influence regulation of the hypothalamic circadian rhythm is important since this could provide a novel target for the treatment of obesity and diabetes.

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Green tea (-)-epigallocatechin-3-gallate counteracts daytime overeating induced by high-fat diet in mice

Abstract: Our study demonstrates that EGCG supplement specifically counteracts daytime overeating induced by HFD in mice, suggesting its central role in regulating feeding behavior and energy homeostasis.

Cited by 37 publications

References 42 publications

EGCG ameliorates high‐fat– and high‐fructose‐induced cognitive defects by regulating the IRS/AKT and ERK/CREB/BDNF signaling pathways in the CNS

EGCG ameliorates high‐fat– and high‐fructose‐induced cognitive defects by regulating the IRS/AKT and ERK/CREB/BDNF signaling pathways in the CNS

(‐)‐Epigallocatechin‐3‐gallate Ameliorates Insulin Resistance and Mitochondrial Dysfunction in HepG2 Cells: Involvement of Bmal1

Dietary Genistein Could Modulate Hypothalamic Circadian Entrainment, Reduce Body Weight, and Improve Glucose and Lipid Metabolism in Female Mice

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