Green tea extract supplementation does not hamper endurance-training adaptation but improves antioxidant capacity in sedentary men

Kuo, Yu Chi; Lin, Jung-Charng; Bernard, Jeffrey R.; Liao, Yi Hung

doi:10.1139/apnm-2014-0538

Cited by 36 publications

(59 citation statements)

References 42 publications

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“…Regarding CK release, no differences between groups were detected. One explanation for this result is the timing of sample collection; the literature reports that, even with intense exercise, high levels of CK may not be detected when sample collection occurs after 24 h following the last training session [49]. TRAP serum results revealed that the ET group had higher antioxidant capacity compared to both sedentary groups, increasing more than twofold (Figure 1A), which agrees with the literature [50].…”

Section: Discussionsupporting

confidence: 87%

Vitamin A Oral Supplementation Induces Oxidative Stress and Suppresses IL-10 and HSP70 in Skeletal Muscle of Trained Rats

et al. 2017

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Exercise training intensity is the major variant that influences the relationship between exercise, redox balance, and immune response. Supplement intake is a common practice for oxidative stress prevention; the effects of vitamin A (VA) on exercise training are not yet described, even though this molecule exhibits antioxidant properties. We investigated the role of VA supplementation on redox and immune responses of adult Wistar rats subjected to swimming training. Animals were divided into four groups: sedentary, sedentary + VA, exercise training, and exercise training + VA. Over eight weeks, animals were submitted to intense swimming 5 times/week and a VA daily intake of 450 retinol equivalents/day. VA impaired the total serum antioxidant capacity acquired by exercise, with no change in interleukin-1β and tumor necrosis factor-α levels. In skeletal muscle, VA caused lipid peroxidation and protein damage without differences in antioxidant enzyme activities; however, Western blot analysis showed that expression of superoxide dismutase-1 was downregulated, and upregulation of superoxide dismutase-2 induced by exercise was blunted by VA. Furthermore, VA supplementation decreased anti-inflammatory interleukin-10 and heat shock protein 70 expression, important factors for positive exercise adaptations and tissue damage prevention. Our data showed that VA supplementation did not confer any antioxidative and/or protective effects, attenuating exercise-acquired benefits in the skeletal muscle.

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Section: Discussionsupporting

confidence: 87%

Vitamin A Oral Supplementation Induces Oxidative Stress and Suppresses IL-10 and HSP70 in Skeletal Muscle of Trained Rats

et al. 2017

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“…Supplementing green tea extract during ten weeks of moderate-intensity endurance training in healthy males resulted in greater fat oxidation while cycling at 55% VO2peak, with no changes observed in the placebo group [109] (Table 4). Untrained men who performed a 4-week training intervention with green tea extract or placebo had similar improvements in VO2max and run to exhaustion time (8.1-9.7 km/h at 18-20% grade), with no differences between groups for total antioxidant status [153]. However, these are performance tasks that would not be expected to benefit from increased fat oxidation rates as they are at an intensity that would be reliant on carbohydrate oxidation [154].…”

Section: Green Tea Extractmentioning

confidence: 94%

Effects of Dietary Supplements on Adaptations to Endurance Training

Rothschild

Bishop

2019

Sports Med

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Endurance training leads to a variety of adaptations at the cellular and systemic levels that serve to minimise disruptions in whole-body homeostasis caused by exercise. These adaptations are differentially affected by training volume, training intensity, and training status, as well as by nutritional choices that can enhance or impair the response to training. A variety of supplements have been studied in the context of acute performance enhancement, but the effects of continued supplementation concurrent to endurance training programs are less well characterised. For example, supplements such as sodium bicarbonate and beta-alanine can improve endurance performance and possibly training adaptations during endurance training by affecting buffering capacity and/or allowing an increased training intensity, while antioxidants such as vitamin C and vitamin E may impair training adaptations by blunting cellular signaling but appear to have little effect on performance outcomes. Additionally, limited data suggest the potential for dietary nitrate (in the form of beetroot juice), creatine, and possibly caffeine, to further enhance endurance training adaptation. Therefore, the objective of this review is to examine the impact of dietary supplements on metabolic and physiological adaptations to endurance training. Abstract word count: 185 Word count: 6,498 Number of tables: 5 Number of figures: 4 Key Points  Many supplements have been studied in the context of acute performance enhancement, but the effects of continued supplementation concurrent to endurance training programs are less well characterised.  Supplements including sodium bicarbonate, beta-alanine, dietary nitrates, antioxidants, caffeine, and creatine have the potential to modify the adaptive response to endurance training (either positively or negatively) by affecting acidbase balance, redox status, oxidant signaling, or cumulative training load, thereby affecting the cellular signaling responses to training.

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“…It was demonstrated that giving antioxidant vitamin C or C and E complex reduced PGC-1 a or NRF2 activation and the whole adaptive response was knocked out ([20], [21], [35], [38], [40], [53], [61] (Table 1.)). However, other investigators noted that the adaptive response is much more complex and regulated by multi protein pathways and signaling agents besides ROS, and also that antioxidant treatment did not eliminate the beneficial effects of exercise [13], [25], [28], [55], [58], [64].…”

Section: Introductionmentioning

confidence: 98%

Exercise, oxidants, and antioxidants change the shape of the bell-shaped hormesis curve

et al. 2017

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It is debated whether exercise-induced ROS production is obligatory to cause adaptive response. It is also claimed that antioxidant treatment could eliminate the adaptive response, which appears to be systemic and reportedly reduces the incidence of a wide range of diseases. Here we suggest that if the antioxidant treatment occurs before the physiological function-ROS dose-response curve reaches peak level, the antioxidants can attenuate function. On the other hand, if the antioxidant treatment takes place after the summit of the bell-shaped dose response curve, antioxidant treatment would have beneficial effects on function. We suggest that the effects of antioxidant treatment are dependent on the intensity of exercise, since the adaptive response, which is multi pathway dependent, is strongly influenced by exercise intensity. It is further suggested that levels of ROS concentration are associated with peak physiological function and can be extended by physical fitness level and this could be the basis for exercise pre-conditioning. Physical inactivity, aging or pathological disorders increase the sensitivity to oxidative stress by altering the bell-shaped dose response curve.

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Green tea extract supplementation does not hamper endurance-training adaptation but improves antioxidant capacity in sedentary men

Cited by 36 publications

References 42 publications

Vitamin A Oral Supplementation Induces Oxidative Stress and Suppresses IL-10 and HSP70 in Skeletal Muscle of Trained Rats

Vitamin A Oral Supplementation Induces Oxidative Stress and Suppresses IL-10 and HSP70 in Skeletal Muscle of Trained Rats

Effects of Dietary Supplements on Adaptations to Endurance Training

Exercise, oxidants, and antioxidants change the shape of the bell-shaped hormesis curve

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