GREEN TEA IMPROVES, AT NUTRITIONAL DOSES, INSULIN SENSITIVITY AND PLASMA LIPIDS CONCENTRATIONS IN OBESE DOG BY INCREASING PPARγ EXPRESSION.

Abstract

In dog as in human, obesity is associated with insulin resistance, dyslipidemia and other chronic diseases. Epidemiological and laboratory studies have shown that green tea has a variety of health effects. The aim of this study was to examine the effects of a green tea supplementation at nutritional doses on insulin sensitivity and plasma lipid concentrations and expression of peroxysome proliferator activated receptor gamma (PPARγ) in a model of obese dog. Ten obese insulin resistant dogs were divided in 2 groups: a “Green tea” group (n = 6) and a control group (n = 4). Dogs of the Green tea group were given, for 12 weeks, a capsule of green tea extract (81 mg/kg/d) just before their single meal. Insulin sensitivity using euglycemic hyperinsulinemic clamp and plasma triglycerides, total cholesterol and free fatty acids concentrations were assessed in each group. Expression of PPARγ gene was studied in visceral and subcutaneous adipose tissue. In “Green tea” group, the insulin sensitivity index increased by 60 ± 11 % (p < .05), plasma triglycerides concentrations decreased by 50 ± 10 % (p < .001) and PPARγ expression significantly increased in both adipose tissues. These findings show that treatment with green tea extract at nutritional doses may reverse some obesity‐related metabolic disorders by improving insulin sensitivity, lipid profile, and PPARγ expression in visceral and subcutaneous adipose tissues.

Red-Skin Extracts of Lotus Seeds Alleviate High-Fat-Diet Induced Obesity via Regulating Lipoprotein Lipase Activity

“…could significantly increase LPL activity by induction of AMPK signaling activity. Serisier et al [ 8 ] reported that dogs who were given green-tea extract for 12 weeks could significantly down-regulate LPL expression in adipose tissues and up-regulate LPL expression in skeletal muscle compared with baseline.…”