Green tea phytocompounds as anticancer: A review

Ullah, Najeeb; Ahmad, Mahboob; Aslam, Hasnain; Tahir, Muhammad Asad; Aftab, Muhammad; Bibi, Nizakat; Ahmad, Sohail

doi:10.1016/s2222-1808(15)61040-4

Cited by 18 publications

(9 citation statements)

References 81 publications

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“…Green tea has been extensively studied both in vitro and in vivo for its anticancer effects (Hayakawa et al., 2016; Ullah et al., 2016). Therefore, we compared the effects of various extraction conditions on the anti-proliferative effects of green tea extracts on both HepG2 and HCT-15 cancer cells.…”

Section: Resultsmentioning

confidence: 99%

Evaluation of ethanol-based extraction conditions of sorghum bran bioactive compounds with downstream anti-proliferative properties in human cancer cells

Cox

Noronha

Herald

et al. 2019

Heliyon

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Certain foods such as turmeric and green tea have been extensively studied for anticancer properties, while high polyphenol sorghum has not received the same attention. Some bioactive compounds in Sorghum bicolor with anticancer activity have been identified, indicating the further need for research and screening methods of high polyphenol sorghum varieties. This study was aimed at improving the extraction of sorghum bioactive compounds by using food-grade solvents using ethanol and citric acid. We used three sorghum varieties and green tea (GT) as a control. The extraction methods were screened for anti-proliferative properties in HepG2 and HCT-15 cancer cell lines, using a cell viability assay. Extraction conditions were improved for anti-proliferative compounds from a high-phenolic sorghum variety (HP), sumac sorghum (CS), and GT. HP was more effective at inhibiting cell viability than CB, CS, and GT. The results demonstrate an efficient method for extracting sorghum bioactive compounds for future anticancer research using food approved ingredients.

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Section: Resultsmentioning

confidence: 99%

Evaluation of ethanol-based extraction conditions of sorghum bran bioactive compounds with downstream anti-proliferative properties in human cancer cells

Cox

Noronha

Herald

et al. 2019

Heliyon

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“…Green tea is a very widespread and commonly used beverage in the world. The majority of anticancer effects from green tea are attributed to EGCG [ 197 , 198 ]. EGCG is able to kill cancer cells notoriously resistant to proapoptotic stimuli and induces death through a necroptosis pathway in many cancer [ 189 ].…”

Section: Insights On the Role Of Flavonoids In Cancermentioning

confidence: 99%

Targeting Cancer with Phytochemicals via Their Fine Tuning of the Cell Survival Signaling Pathways

Chirumbolo

Bjørklund

Lysiuk

et al. 2018

IJMS

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The role of phytochemicals as potential prodrugs or therapeutic substances against tumors has come in the spotlight in the very recent years, thanks to the huge mass of encouraging and promising results of the in vitro activity of many phenolic compounds from plant raw extracts against many cancer cell lines. Little but important evidence can be retrieved from the clinical and nutritional scientific literature, where flavonoids are investigated as major pro-apoptotic and anti-metastatic compounds. However, the actual role of these compounds in cancer is still far to be fully elucidated. Many of these phytochemicals act in a pleiotropic and poorly specific manner, but, more importantly, they are able to tune the reactive oxygen species (ROS) signaling to activate a survival or a pro-autophagic and pro-apoptosis mechanism, depending on the oxidative stress-responsive endowment of the targeted cell. This review will try to focus on this issue.

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“…One of these is green tea ( Camellia sinensis ) for which its phytocompounds have been proven to have anticancer properties [ 51 ]. It provides protection against environmental factors that affect homeostasis, such as genotoxic substances and free radicals [ 52 ].…”

Section: Comparing Emergent Extracts With Classicsmentioning

confidence: 99%

Bioactive Compounds and Extracts from Traditional Herbs and Their Potential Anti-Inflammatory Health Effects

Serrano,

Ros,

Nieto

2018

Medicines

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The inflammatory processes associated with several chronic illnesses like cardiovascular disease and cancer have been the focus of mechanistic studies of the pathogenicity of these diseases and of the use of different pharmacological and natural methods to prevent them. In this study we review the current evidence regarding the effectiveness of natural extracts from as-yet little-studied traditional botanical species in alleviating the inflammation process associated with several chronic diseases. Additionally, the intention is to expose the known pathways of action and the potential synergistic effects of the constituent compounds of the discussed extracts. It is noted that the here-studied extracts, which include black garlic rich in S-allylcystein, polyphenols from cat’s claw (Uncaria tomentosa), devil’s claw (Harpagophytum procumbens), camu-camu (Myrciaria dubia), and blackcurrant (Ribes nigrum), and citrus fruit extracts rich in hesperidin, have similar or greater effects than other, more extensively studied extracts such as tea and cocoa. The combined use of all of these extracts can give rise to synergetic effects with greater biological relevance at lower doses.

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Green tea phytocompounds as anticancer: A review

Cited by 18 publications

References 81 publications

Evaluation of ethanol-based extraction conditions of sorghum bran bioactive compounds with downstream anti-proliferative properties in human cancer cells

Evaluation of ethanol-based extraction conditions of sorghum bran bioactive compounds with downstream anti-proliferative properties in human cancer cells

Targeting Cancer with Phytochemicals via Their Fine Tuning of the Cell Survival Signaling Pathways

Bioactive Compounds and Extracts from Traditional Herbs and Their Potential Anti-Inflammatory Health Effects

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