Green Tea Polyphenols and Sulfasalazine have Parallel Anti-Inflammatory Properties in Colitis Models

Oz, Helieh S.; Chen, Theresa; Villiers, Willem J.S. de

doi:10.3389/fimmu.2013.00132

Cited by 174 publications

(142 citation statements)

References 57 publications

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“…() had determined the clear composition of the Fuzhuan tea extract (Table ). One of the ingredient, was green tea polyphenols (Oz et al ., ), proven to be effective in colitis, which supported our findings. A dose of 6.9 mg kg −1 EGCG has been demonstrated to exert anti‐inflammatory and anti‐oxidative properties and to reduce reactive oxygen species in the inflamed colon tissues (Bruckner et al ., ).…”

Section: Discussionsupporting

confidence: 91%

Crude extract of Fuzhuan brick tea ameliorates DSS‐induced colitis in mice

Liu

Yang

Zeng

et al. 2016

Int J of Food Sci Tech

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Summary Inflammatory bowel disease (IBD) is highly prevalent worldwide and includes ulcerative colitis (UC) and Crohn's disease. It is a high incidence rate disease all over the world and an inducement of colon cancer. The aim of this study was to investigate the potential protective effect of Fuzhuan brick tea (FBT) against colitis induced by dextran sulphate sodium (DSS) in mice. ICR mice were administered FBT orally for 7 days before drinking 3% DSS (w/v). The FBT significantly attenuated the symptoms of colitis including diarrhoea, rectal bleeding and loss of body weight. FBT reduced the shortening of colon length and alleviated the histopathological damages. The myeloperoxidase activity, nitric oxide and malondialdehyde level in colon tissues were also significantly decreased by FBT. Besides, FBT treatment obviously suppressed the expression of the inflammatory cytokines such as TNF‐α, IL‐1β and IFN‐γ. Our results provide a safe and efficient method for preventing and treating colitis.

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Section: Discussionsupporting

confidence: 91%

Crude extract of Fuzhuan brick tea ameliorates DSS‐induced colitis in mice

Liu

Yang

Zeng

et al. 2016

Int J of Food Sci Tech

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“…Such changes in gut microbial community are correlated as well with the increasing rate of IBD; particularly, frequent consumption of fast food meals, fatty acids and reduced intake of fruit and vegetables have been associated with the disease development [43–46]. Moreover, polyphenols contained in fruit, and at high concentrations in green tea, can help to increase the levels of antioxidants and attenuate severity of colitis in the analogous way to sulfasalazine, reducing the rate of IBD in Iranians [43, 47]. The result of this study proposes that pasteurized milk would need to be considered as a weak transmission vector confirming the previous report [48] and is in line with other reports.…”

Section: Discussionmentioning

confidence: 99%

Mycobacterium avium subsp. paratuberculosis and associated risk factors for inflammatory bowel disease in Iranian patients

et al. 2017

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BackgroundInflammatory bowel disease (IBD) is described as a relapsing condition with high morbidity and uncertain complex pathogenesis. The association of Mycobacterium avium ssp. paratuberculosis (MAP) with Crohn’s disease (CD) in human has been debated for decades, however there is no confirmed data to verify such relations in Iran. The aim of this study was to investigate risk factors and a possible role of MAP in Iranian patients with CD.MethodsAnti-MAP antibodies were detected in serum of IBD patients and subjects without IBD (nIBD) through ELISA; MAP DNA and viable MAP cells were identified in patients’ biopsies through nested PCR and direct culture methods, respectively. Principal component analysis (PCA) was used to investigate the risk factors in relation to IBD and MAP infection.ResultsPositivity for IS900 PCR was detected in 64% (n = 18) of CD, 33% (n = 10) of ulcerative colitis (UC) and 9.7% (n = 6) of nIBD samples. Live MAP cells were isolated from biopsies of 2 CD patients only. Among 28 patients with CD, 46% (n = 13) and 39% (n = 11) were positive for antibodies against MAP3865c133–141 and MAP3865c125–133 peptides, respectively, whereas much lower seroreactivity was detected in UC subjects accounting for 3% (n = 1) for MAP3865c133–141 and 16.7% (n = 5) for MAP3865c125–133. A high immune reactivity to MAP epitopes among CD patients was positively correlated with consumption of fast food meals and IBD familiarity. For both CD and UC, breastfeeding period and consumption of fruit/vegetables presented negative correlation with the presence of anti-MAP antibodies.ConclusionsThis study provided evidences that high prevalence of MAP DNA and anti-MAP antibodies in CD patients is significantly associated with the development of CD. Despite the role of several factors contributing to IBD, the presence of MAP DNA and anti-MAP antibodies in Iranian CD patients highlights a possible transmission of MAP from animal-derived products to humans.

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“…Heart, liver, and uterus were excised and weighed. Colonic contents were removed and colonic length and weigh data measured and flash frozen in liquid nitrogen and stored at −80°C for future studies [32] [33]. Live fetuses were removed from uteri, counted, and weighed and their lengths measured using a digital caliper.…”

Section: Methodsmentioning

confidence: 99%

Novel Synergistic Protective Efficacy of Atovaquone and Diclazuril on Fetal-Maternal Toxoplasmosis

Oz¹

2014

IJCM

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Over 1 billion people globally are estimated to be infected with Toxoplasma gondii with severe or unknown consequences and no safe and effective therapies are available against congenital or persistent chronic infection. We propose that atovaquone and diclazuril synergistically protect against fetal-maternal toxoplasmosis. Methods Programmed pregnant mice were treated with atovaquone and diclazuril monotherapy, or combined (atovaquone + diclazuril) therapy and infected with tachyzoites (0, 300, 600) and the course of infection was studied. Results Infected dams with low dose (300) developed moderate toxoplasmosis complications and treatments were similarly effective with minor differences between monotherapies. In contrast, major differences were observed amongst varied treatments during high-dose (600) infection and severe related- toxoplasmosis complications as follows. Dams developed hydrothorax, ascities and excess weight gain. Combined therapy (P < 0.01) and to a lesser extent diclazuril monotherapy (P < 0.05) protected dams from excess weight, hydrothorax, and ascities. Infected dams exhibited splenomegaly, hepatomegaly and severe hepatitis. Combined therapy synergistically normalized pathology (P < 0.001) and to a lesser degree monotherapy (diclazuril P < 0.01, and atovaquone P < 0.05) protected dams from hepatitis and splemomegaly. Additionally, behavioral response to pain stimuli and fetal weight and fetal numbers were significantly preserved in treated dams Conclusions This is the first report describing combined atovaquone and diclazuril therapy (a) to be safe in pregnancy, (b) to exert novel synergistic effects, and (c) to protect dams and their nested fetuses against adverse effects of severe toxoplasmosis.

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Green Tea Polyphenols and Sulfasalazine have Parallel Anti-Inflammatory Properties in Colitis Models

Cited by 174 publications

References 57 publications

Crude extract of Fuzhuan brick tea ameliorates DSS‐induced colitis in mice

Crude extract of Fuzhuan brick tea ameliorates DSS‐induced colitis in mice

Mycobacterium avium subsp. paratuberculosis and associated risk factors for inflammatory bowel disease in Iranian patients

Novel Synergistic Protective Efficacy of Atovaquone and Diclazuril on Fetal-Maternal Toxoplasmosis

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