Crude extract of Fuzhuan brick tea ameliorates <scp>DSS</scp>‐induced colitis in mice

Liu, Bo; Yang, Tao; Zeng, Linna; Shi, Limin; Li, Yan; Xia, Zanguo; Xia, Xuping; Lin, Qinlu; Luo, Feijun

doi:10.1111/ijfs.13241

Cited by 25 publications

(13 citation statements)

References 38 publications

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“…Previous studies have shown that a dosage of 5–60 mg/kg of unaged pu-erh tea can alleviate colitis in mice better, , but the optimal dosage of aged ripe pu-erh tea has not been defined. In the previous experiment, (DSS salt, molecular weight = 36–50 kDa) DSS-treated mice, which received normal diet and 3.5% (w/v) DSS in drinking water, were given intragastric administration with various concentrations of P2006 (1, 10, 50, 100, and 200 mg/kg bw) to confirm the best concentration.…”

Section: Methodsmentioning

confidence: 99%

Aged Ripe Pu-erh Tea Reduced Oxidative Stress-Mediated Inflammation in Dextran Sulfate Sodium-Induced Colitis Mice by Regulating Intestinal Microbes

Shi

Liu

et al. 2021

J. Agric. Food Chem.

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Ripened pu-erh tea has the biological activity of antioxidation and anti-inflammation, which inhibits the related parameters of colitis. However, the role of storage-induced changes in bioactive ingredients of ripened pu-erh tea in colitis remains unclear. In this study, 3.5% dextran sulfate sodium-induced colitis mice were treated with 10 mg/kg bw/day extracts, aged 14 years (P2006) and unaged (P2020) ripened pu-erh tea, respectively, for 1 week. We found that ripened pu-erh tea, especially P2006, inhibited the intestinal oxidative stress-mediated inflammation pathway (TLR4/MyD88/ROS/p38MAPK/NF-κB p65), upregulated the expression of intestinal tight junction proteins (Mucin-2, ZO-1, occludin), promoted M2 polarization of macrophages, and in turn, improved the intestinal immune barrier, which stemmed from the reshaping of intestinal microbiota (e.g., increased Lachnospiraceae_NK4A136_group and Akkermansia levels). Our results speculate that drinking aged ripe pu-erh tea (10 mg/kg bw/ day in mice, a human equivalent dose of 7 g/60 kg bw/day) has a practical effect on alleviating and preventing the development of intestinal inflammation.

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Section: Methodsmentioning

confidence: 99%

Aged Ripe Pu-erh Tea Reduced Oxidative Stress-Mediated Inflammation in Dextran Sulfate Sodium-Induced Colitis Mice by Regulating Intestinal Microbes

Shi

Liu

et al. 2021

J. Agric. Food Chem.

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“…Similarly, L. coreana , containing a characteristic phytochemical profile, showed anti‐inflammatory effects in different studies . Recently, the therapeutic effects of colitis have been found in green, black, and dark teas . However, the difference in the phytochemical composition of these teas may result in different in vitro and in vivo biological activities.…”

Section: Introductionmentioning

confidence: 99%

Camellia sinensis and Litsea coreana Ameliorate Intestinal Inflammation and Modulate Gut Microbiota in Dextran Sulfate Sodium‐Induced Colitis Mice

Liu

Wang

Chen

et al. 2020

Molecular Nutrition Food Res

112

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Scope Polyphenol‐enriched herbal extracts have been proved as alternative therapeutic strategies for experimentally induced colitis. The in vivo and in vitro anti‐inflammatory effects of Camellia sinensis (green, white, yellow, oolong, black, and dark tea) and Litsea coreana (hawk tea) are comparatively explored. Methods and results HPLC analysis confirms dissimilarities among phytochemical compositions of these teas. The tea extracts (TEs) significantly decrease the production of pro‐inflammatory cytokines (IL‐6, IL‐12, and tumor necrosis factor‐α) and increase the anti‐inflammatory cytokines (IL‐10) in LPS‐stimulated RAW 264.7 macrophages and a dextran sodium sulfate (DSS)‐induced colitis mouse model. The treatment of TEs in colitis mice can ameliorate colon inflammation, pro‐oxidative enzyme activity, colon integrity, and suppress the activation of nuclear factor‐κB. Of note, green TE significantly attenuates the DSS‐induced decrease in richness and diversity of gut microbiota. Moreover, TEs are capable of exerting a prebiotic effect on gut microbiota by increasing the abundance of potentially beneficial bacteria (e.g., Faecalibaculum, and Bifidobacterium), and decreasing the abundance of potentially harmful bacteria (e.g., Bacteroids, and Mucispirillum). TEs restore the decreased production of SCFAs in the feces of colitic mice. Conclusion The treatment of seven types of tea can alleviate DSS‐induced colitis in mice, and modulate the dysbiosis of gut microbiota in colitis mice.

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“…Furthermore, Fuzhuan brick tea (FBT), one of the unique dark teas mainly produced in the Hunan and Shanxi provinces of China with the help of aerobic or anaerobic microbial fermentation, has been used as a nutritional supplement for people in the border regions of Southern/Western China since the 1860s. , The traditional manufacturing process of FBT mainly includes withering, steaming, rolling, microbial fermentation, drying, screening, pile fermentation, compact shaping, and packaging . Nowadays, FBT has received increasing attention due to its unique flavor and various health-promoting functions, including antioxidant, hepatoprotective, antiobesity, , anti-inflammatory, and antibacterial activities. However, the bioactive components in FBT contributing to the health-promoting functions remain unclear.…”

Section: Introductionmentioning

confidence: 99%

Structural Characterization and Immunostimulatory Activity of Heteropolysaccharides from Fuzhuan Brick Tea

Chen

Bai

Zeng

et al. 2021

J. Agric. Food Chem.

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Fuzhuan brick tea (FBT), one of the unique dark teas, has various health-promoting functions. In the present study, one polysaccharide fraction, namely FBTPS-2-1, was extracted and purified from FBT, and its structure and potential immunostimulatory activity were investigated. The results showed that FBTPS-2-1,one of typical heteropolysaccharides, was mainly composed of Gal, Ara, and Glc with little molar content of Man, Rha, GalA, and GlcA in molar ratio of 46.59:22.13:13.57:8.20:6.02:2.12:1.38 and molecular weight of 748 kDa. The backbone of FBTPS-2-1 contained →4)-β-d-Galp-(1→4)-β-d-Galp-(1→, →4)-β-d-Galp-(1→4)-α-d-Glcp-(1→, →4)-α-d-Glcp-(1→4)-α-d-Glcp-(1→, →4)-α-d-Glcp-(1→4)-β-d-Galp-(1→, →3)-β-d-Galp-(1→4)-β-d-Galp-(1→, →3,6)-β-d-Galp-(1→3)-β-d-Galp-(1→ and →3,6)-β-d-Galp-(1→3,6)-β-d-Galp-(1→. The linkages of branches in FBTPS-2-1 were mainly composed of α-l-Araf-(1→3,6)-β-d-Galp-(1→, →5)-α-l-Araf-(1→3,6)-β-d-Galp-(1→, →6)-β-d-Galp-(1→3,6)-β-d-Galp-(1→, α-l-Araf-(1→3,5)-α-l-Araf-(1→, →3,5)-α-l-Araf-(1→5)-α-l-Araf-(1→, α-d-Galp-(1→3,5)-α-l-Araf-(1→ and →5)-α-l-Araf-(1→6)-β-d-Galp-(1→. Furthermore, FBTPS-2-1 could increase the phagocytosis of macrophages and promote the secretion of NO and a variety of inflammatory cytokines, including TNF-α, IL-1β, and IL-6, indicating noticeable immune enhancement activity. Thus, FBTPS-2-1 could serve as a potentially functional food to improve human health by modulating the host immunoreaction.

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Crude extract of Fuzhuan brick tea ameliorates DSS‐induced colitis in mice

Cited by 25 publications

References 38 publications

Aged Ripe Pu-erh Tea Reduced Oxidative Stress-Mediated Inflammation in Dextran Sulfate Sodium-Induced Colitis Mice by Regulating Intestinal Microbes

Aged Ripe Pu-erh Tea Reduced Oxidative Stress-Mediated Inflammation in Dextran Sulfate Sodium-Induced Colitis Mice by Regulating Intestinal Microbes

Camellia sinensis and Litsea coreana Ameliorate Intestinal Inflammation and Modulate Gut Microbiota in Dextran Sulfate Sodium‐Induced Colitis Mice

Structural Characterization and Immunostimulatory Activity of Heteropolysaccharides from Fuzhuan Brick Tea

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