Green Tea Polyphenols Inhibit the Sodium-Dependent Glucose Transporter of Intestinal Epithelial Cells by a Competitive Mechanism

Kobayashi, Yôko; Suzuki, Miho; Satsu, Hideo; Arai, Soichi; Hara, Yukihiko; Suzuki, Koichi; Miyamoto, Yusei; Shimizu, Makoto

doi:10.1021/jf0006832

Cited by 343 publications

(263 citation statements)

References 27 publications

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“…So, we know that coffee contains many compounds, which may have potential to influence glucose metabolism process to prevent hyperglycemia and oxidative stress consequently. For instance, chlorogenic acid inhibits glucose transporters (Na þ -dependent glucose transporter) (Kobayashi et al, 2000). Chlorogenic acid also reduces or inhibits glucose-6-phosphatase (Glc-6-phase) hydrolysis, which may reduce plasma glucose output from the liver, leading to reduced plasma glucose concentration (Newgard et al, 1984;Arion et al, 1997).…”

Section: Discussionmentioning

confidence: 99%

Coffee consumption, serum γ-glutamyltransferase and risk of type II diabetes

Bidel

Silventoinen

et al. 2007

Eur J Clin Nutr

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Objectives: To study the joint association of coffee consumption and serum g-glutamyltransferase (GGT) levels on the risk of developing type II diabetes. Design, setting and subjects: A total of 21 826 Finnish men and women who were 35-74 years of age and without any history of diabetes at baseline (years 1982, 1987, 1992 and 1997) were included in the present analyses. They were prospectively followed up for onset of type II diabetes (n ¼ 862 cases), death or until the end of the year 2002. Coffee consumption, serum GGT and other study parameters were determined at baseline using standardized measurements. Analyses were stratified by the serum GGT level classified into two classes using the 75th sex-specific percentiles as the cut point. Results: Coffee consumption was significantly and inversely associated with incident diabetes among both men and women. Serum GGT modified the association between coffee consumption and incident diabetes. Subjects in the high category of coffee consumption with the GGT level X75th percentile showed a significant inverse association for women, and for both sexes combined. The association was not significant in subjects with the GGT level p75th percentile. There was a significant interaction effect of GGT and coffee consumption on risk of type II diabetes in data of women (P ¼ 0.05) and in both sexes combined (P ¼ 0.02). Conclusions: Habitual coffee consumption is associated with lower incidence of type II diabetes particularly in those with higher baseline serum GGT levels.

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Section: Discussionmentioning

confidence: 99%

Coffee consumption, serum γ-glutamyltransferase and risk of type II diabetes

Bidel

Silventoinen

et al. 2007

Eur J Clin Nutr

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“…29 On the other hand, it has also been reported that tea catechins including EGCG could inhibit the sodiumdependent glucose transporter. 30 If the reduced energy absorption is taken into account, EGCG resulted in a slightly (but not significantly) reduced total energy digestion of about 200 kJ throughout the 4-week treatment period (control: 2790 kJ, EGCG 0.5%: 2565 kJ, EGCG 1%: 2587 kJ). In total, 200 kJ correspond to the energy content of approximately 5 g lipids, which is very close to the difference in body fat gain between the control group and the 1% EGCG group.…”

Section: Egcg Prevents Obesity S Klaus Et Almentioning

confidence: 93%

Epigallocatechin gallate attenuates diet-induced obesity in mice by decreasing energy absorption and increasing fat oxidation

et al. 2005

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OBJECTIVE:To examine the antiobesity effect of epigallocatechin gallate (EGCG), a green tea bioactive polyphenol in a mouse model of diet-induced obesity. METHODS: Obesity was induced in male New Zealand black mice by feeding of a high-fat diet. EGCG purified from green tea (TEAVIGOt) was supplemented in the diet (0.5 and 1%). Body composition (quantitative magnetic resonance), food intake, and food digestibility were recorded over a 4-week period. Animals were killed and mRNA levels of uncoupling proteins (UCP1-3), leptin, malic enzyme (ME), stearoyl-CoA desaturase-1 (SCD1), glucokinase (GK), and pyruvate kinase (PK) were analysed in different tissues. Also investigated were acute effects of orally administered EGCG (500 mg/kg) on body temperature, activity (transponders), and energy expenditure (indirect calorimetry). RESULTS: Dietary supplementation of EGCG resulted in a dose-dependent attenuation of body fat accumulation. Food intake was not affected but faeces energy content was slightly increased by EGCG, indicating a reduced food digestibility and thus reduced long-term energy absorption. Leptin and SCD1 gene expression in white fat was reduced but SCD1 and UCP1 expression in brown fat was not changed. In liver, gene expression of SCD1, ME, and GK was reduced and that of UCP2 increased. Acute oral administration of EGCG over 3 days had no effect on body temperature, activity, and energy expenditure, whereas respiratory quotient during night (activity phase) was decreased, supportive of a decreased lipogenesis and increased fat oxidation. CONCLUSIONS: Dietary EGCG attenuated diet-induced body fat accretion in mice. EGCG apparently promoted fat oxidation, but its fat-reducing effect could be entirely explained by its effect in reducing diet digestibility.

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“…It was shown that green tea treatment of diabetic rats significantly reduced the blood glucose level. This antihyperglycemic effect may be linked to enhanced basal and insulin-stimulated glucose uptake in rat adipocytes [139], inhibition of the intestinal glucose transporter [140], and decreased expression of genes that control gluconeogenesis [141]. Green tea supplementation also reduced the accumulation of AGEs in diabetic rats as indicated by decreased collagen linked fluorescence [49].…”

Section: E (+)-Catechin (−)-Catechin (+)-Epicatechin and (−)-Epicmentioning

confidence: 99%