Grey matter volume alterations in trigeminal neuralgia: A systematic review and meta-analysis of voxel-based morphometry studies

Tang, Yu; Wang, Maohua; Tian, Zheng; Yuan, Fengying; Yang, Han; Han, Fei; Chen, Guangxiang

doi:10.1016/j.pnpbp.2019.109821

Cited by 27 publications

(21 citation statements)

References 61 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…In this study, compared to HC, in TN wNVC, the GM volume deficits were widely distributed across the thalamus, superior frontal gyrus, inferior frontal gyrus, middle temporal gyrus, angular gyrus, and posterior central gyrus. These affected regions were mostly consistent with those reported by previously published large-sized VBM analyses and meta-analyses which have reported that patients with CTN show GM volume deficits throughout the frontal, temporal and parietal lobes; cingulate and insular cortices; and thalamus [17][18][19][20][21][22][23]. In contrast, in patients with TN woNVC as compared with HC, we observed almost all reductions in GM volume were bilateral symmetrical, which were limited to the bilateral inferior temporal gyrus, bilateral PCC.…”

Section: Discussionsupporting

confidence: 91%

Gray and white matter abnormalities in primary trigeminal neuralgia with and without neurovascular compression

Jiang

Qiu

et al. 2020

J Headache Pain

View full text Add to dashboard Cite

Purpose Previous researches have reported gray and white matter microalterations in primary trigeminal neuralgia (TN) with neurovascular compression (NVC). The central mechanism underlying TN without NVC are unknown but may include changes in specific brain regions or circuitries. This study aimed to investigate abnormalities in the gray matter (GM) and white matter (WM) of the whole brain and the possible pathogenetic mechanism underlying this disease. Methods We analyzed brain morphologic images of TN patients, 23 with NVC (TN wNVC) and 22 without NVC (TN wNVC) compared with 45 healthy controls (HC). All subjects underwent 3T-magnetic resonance imaging and pain scale evaluation. Voxel-based morphometry (VBM) and surface-based morphometry (SBM) were used to investigate whole brain grey matter quantitatively; graph theory was applied to obtain network measures based on extracted DTI data based on DTI data of the whole brains. Sensory and affective pain rating indices were assessed using the visual analog scale (VAS) and short-form McGill Pain Questionnaire (SF-MPQ). Results The VBM and SBM analyses revealed widespread decreases in GM volume and cortical thickness in TN wNVC compared to TN woNVC, and diffusion metrics measures and topology organization changes revealed DTI showed extensive WM integrity alterations. However, above structural changes differed between TN wNVC and TN woNVC, and were related to specific chronic pain modulation mechanism. Conclusion Abnormalities in characteristic regions of GM and WM structural network were found in TN woNVC compared with TN wNVC group, suggesting differences in pathophysiology of two types of TN.

show abstract

Section: Discussionsupporting

confidence: 91%

Gray and white matter abnormalities in primary trigeminal neuralgia with and without neurovascular compression

Jiang

Qiu

et al. 2020

J Headache Pain

View full text Add to dashboard Cite

show abstract

“…The pain intensity processing of SMN network was supported by our correlation analysis between the static ALFF in precentral/postcentral gyrus and VAS scores. The thalamus is a key gate for processing sensory and motor signals and is as a hub for information exchanges between different subcortical areas and the cerebral cortex ( Hwang et al, 2017 ; Lipiec and Wisniewska, 2019 ; Tang et al, 2020 ). It is also plays an important role in regulation of consciousness ( Steriade and Llinas, 1988 ; Redinbaugh et al, 2020 ).…”

Section: Discussionmentioning

confidence: 99%

Static and Dynamic Changes of Amplitude of Low-Frequency Fluctuations in Cervical Discogenic Pain

Zhang

Liu

et al. 2020

Front. Neurosci.

View full text Add to dashboard Cite

Cervical discogenic pain (CDP) is a clinically common pain syndrome caused by cervical disk degeneration. A large number of studies have reported that CDP results in brain functional impairments. However, the detailed dynamic brain functional abnormalities in CDP are still unclear. In this study, using resting-state functional magnetic resonance imaging, we explored the neural basis of CDP with 40 CDP patients and 40 age-, gender-matched healthy controls to delineate the changes of the voxel-level static and dynamic amplitude of low frequency fluctuations (ALFF). We found increased static ALFF in left insula (INS) and posterior precuneus (PCu), and decreased static ALFF in left precentral/postcentral gyrus (PreCG/PoCG), thalamus (THA), and subgenual anterior cingulate cortex in CPD patients compared to healthy controls. We also found decreased dynamic ALFF in left PreCG/PoCG, right posterior middle temporal gyrus, and bilateral THA. Moreover, we found that static ALFF in left PreCG/PoCG and dynamic ALFF in THA were significantly negatively correlated with visual analog scale and disease duration, respectively. Our findings provide the neurophysiological basis for CDP and facilitate understanding the neuropathology of CDP.

show abstract

“…The 12-point checklist involved in the previous meta-analysis of VBM studies was used to assess the quality of each study selected for this meta-analysis ( Tang et al, 2020 ), which is shown in Supplementary Table 2 . Literature search, study evaluation, and selection were independently performed by two investigators (TM and Y-YJ), and all controversial discrepancies were resolved by a third investigator (L-FY) for the final decision.…”

Section: Methodsmentioning

confidence: 99%

Gray Matter Volume Abnormality in Chronic Pain Patients With Depressive Symptoms: A Systemic Review and Meta-Analysis of Voxel-Based Morphometry Studies

Yan

et al. 2022

Front. Neurosci.

View full text Add to dashboard Cite

BackgroundGray matter volume (GMV) alteration in specific brain regions has been widely regarded as one of the most important neuroplasticity features in chronic pain patients with depressive symptoms (CP-D). However, the consistent and significant results were still lacking. Thus, further exploration was suggested to be performed.ObjectivesThis study aimed to comprehensively collect the voxel-based morphometry (VBM) studies on GMV alteration between CP-D and healthy controls (HCs). And a systemic review and meta-analysis were made to explore the characteristic brain regions in chronic pain and depression comorbidity.MethodsSearch of PubMed, MEDLINE, Web of Science, and Cochrane Library databases updated to July 13, 2021. The altered GMV between CP-D and HCs in VBM studies was included in this meta-analysis. In total, 18 studies (20 datasets) and 1320 participants (520 patients and 800 HCs) were included. The significant coordinate information (x, y, z) reported in standard space and the effect size (t-value or z-score) were extracted and analyzed by anisotropic effect size-signed differential mapping (AES-SDM) 5.15 software.ResultsAccording to the main analysis results, CP-D showed significant and consistent increased GMV in the left hippocampus (HIP. L) and decreased GMV in the medial part of the left superior frontal gyrus (SFG. L, BA 10) compared to HCs. Subgroup analysis showed significant decreased GMV in the medial orbital part of SFG.R (BA 10) in neuropathic pain, as well as significant increased GMV in the right parahippocampal gyrus (PHG.R, BA 35), left hippocampus (HIP.L, BA 20), and right middle frontal gyrus (MFG.R) in musculoskeletal pain. Furthermore, meta-regression showed a positive relationship between the decreased GMV in the medial part of SFG.L and the percentage of female patients.ConclusionGMV abnormality in specific brain areas (e.g., HIP.L and SFG) was robust and reproducible, which could be significantly involved in this comorbidity disease. The findings in this study may be a valuable reference for future research.Systematic Review Registration[www.crd.york.ac.uk/prospero/].

show abstract

Grey matter volume alterations in trigeminal neuralgia: A systematic review and meta-analysis of voxel-based morphometry studies

Cited by 27 publications

References 61 publications

Gray and white matter abnormalities in primary trigeminal neuralgia with and without neurovascular compression

Gray and white matter abnormalities in primary trigeminal neuralgia with and without neurovascular compression

Static and Dynamic Changes of Amplitude of Low-Frequency Fluctuations in Cervical Discogenic Pain

Gray Matter Volume Abnormality in Chronic Pain Patients With Depressive Symptoms: A Systemic Review and Meta-Analysis of Voxel-Based Morphometry Studies

Contact Info

Product

Resources

About