Grip Strength Cut Points for Diabetes Risk Among Apparently Healthy U.S. Adults

Brown, Elise C.; Buchan, Duncan S.; Madi, Samar A.; Gordon, Breanne N.; Drignei, Dorin

doi:10.1016/j.amepre.2020.01.016

Cited by 20 publications

(20 citation statements)

References 40 publications

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“…Therefore, relative grip strength may be a practical method to identify people who have muscle weakness, who are at high risk of developing T2DM. 25 Our findings partially agree with existing evidence regarding the association of muscle strength and T2DM risk. 2 11-13 26 A recent meta-analysis conducted in 39 233 incident T2DM cases and 1 713 468 participants without diabetes from 13 studies reported that 1 SD higher absolute grip strength was associated with a 24% lower risk of T2DM when the analyses were not adjusted for adiposity (mainly BMI), however, the association was attenuated but remained significant when the analyses were adjusted for adiposity (13% lower risk of T2DM per 1 SD higher grip strength).…”

Section: Discussionsupporting

confidence: 91%

“…A recent study conducted in 5108 participants aged 20-80 years from the National Health and Nutrition Examination Survey has derived new grip strength cut-off points that could be used as a screening tool for diabetes risk in apparently healthy adults. 25 However, future studies are needed to formally assess whether grip strength improves the prediction ability of the current risk score for T2DM.…”

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confidence: 99%

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Associations between grip strength and incident type 2 diabetes: findings from the UK Biobank prospective cohort study

Boonpor

Parra‐Soto

Petermann‐Rocha

et al. 2021

BMJ Open Diab Res Care

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IntroductionGrip strength has been associated with chronic diseases and mortality. However, current evidence of the association between grip strength and incident type 2 diabetes mellitus (T2DM) is controversial. The aim of this study was to investigate the associations of absolute and relative grip strength with incident T2DM and whether these associations differ by sociodemographic, lifestyle and adiposity-related factors.Research design and methodsThis was a prospective cohort study of 166 894 participants in the UK Biobank (mean age 56.5 years, 54.4% women). The outcome was T2DM incidence and the exposure was grip strength, expressed in absolute (kg) and relative (kg per kg of body weight) values. The association between grip strength and T2DM incidence was investigated using Cox-proportional regression.ResultsThe median follow-up was 5.3 years (IQR: 4.7–6.1). During this time, 3713 participants developed T2DM. Lower grip strength was associated with a higher risk of T2DM in both sexes. Those in the lowest quintile of absolute grip strength had a 50% higher risk in men (HR: 1.50 (95% CI: 1.30 to 1.73)) and 25% higher risk in women (HR: 1.25 (95% CI: 1.06 to 1.47)) compared with those in the highest quintile. For relative grip strength, risk of diabetes was more than double for men (HR: 2.22 (95% CI: 1.84 to 2.67)) and 96% higher for women (HR: 1.96 (95% CI: 1.52 to 2.53)) in the lowest compared with highest quintiles.ConclusionsGrip strength is associated with a higher risk of T2DM incidence in both men and women independent of important confounding factors including age, deprivation, adiposity and lifestyle. However, the associations were stronger when grip strength is expressed relative to body weight, which could reflect the importance of muscle quality.

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Section: Discussionsupporting

confidence: 91%

mentioning

confidence: 99%

Associations between grip strength and incident type 2 diabetes: findings from the UK Biobank prospective cohort study

Boonpor

Parra‐Soto

Petermann‐Rocha

et al. 2021

BMJ Open Diab Res Care

View full text Add to dashboard Cite

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“…Grip strength can be measured easily with a portable dynamometer, and provides the most common single diagnostic measure of muscle strength and performance [3,4]. Grip strength is a marker of health, and low values have been found to predict fractures, disability, type 2 diabetes, hospital outcomes, all-cause mortality, cardiovascular and cancer death, and cardiovascular disease [5][6][7][8][9][10][11][12]. Longitudinal decline in grip strength for an individual is also a strong risk factor for adverse outcomes [13].…”

Section: Introductionmentioning

confidence: 99%

Association of Body Shape Index (ABSI) with Hand Grip Strength

Krakauer

2020

IJERPH

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Hand grip is a leading measure of muscle strength and general health, yet its association with body shape is not well characterized. Here, we examine correlations between grip strength, a body shape index (ABSI), and body mass index (BMI) in the 2011–2014 United States National Health and Nutrition Examination Survey cohorts. Grip strength was found to correlate negatively with ABSI (though positively with BMI), suggesting that those with a more central body profile tend to be weaker than others with the same weight. Individuals with low grip strength, as well as those with high ABSI, were more likely to die during follow up, whereas there was no association of BMI with mortality hazard. Transforming the grip strength, ABSI, and BMI by taking their logarithm prior to standardization did not meaningfully change the associations seen. These findings suggest that combining anthropometrics (ABSI, BMI) with grip strength may better identify individual mortality hazard in research studies and clinical practice.

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“…In addition, the insulin resistance state within skeletal muscle occurs as a result of greater intramuscular adipose tissue and muscle atrophy [47], thus damaging skeletal muscle [48]. In view of the apparent association between HGS and diabetes, HGS has been proposed to be used as a diabetes screening tool among apparently healthy adults [49].…”

Section: Discussionmentioning

confidence: 99%

Handgrip strength and its association with noncommunicable diseases and their risk factors among elderly individuals in Malaysia

Shah¹,

Safian²,

Ahmad³

et al. 2020

Preprint

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Background: Handgrip strength (HGS) is indicative of overall physical health among older people. A reduction in HGS may be associated with an increased risk of disease. This study aims to assess the association between HGS and noncommunicable diseases (NCDs) and the related risk factors.Methods: One thousand two hundred four (1204) participants from four areas in Selangor state, Malaysia, were recruited. A comprehensive face-to-face interview based on the Bahasa Malaysia version of the Japan Gerontological Evaluation Study (JAGES-BM) questionnaire was administered, followed by HGS assessments by a handgrip dynamometer.Results: The mean age of the participants was 68.7 (SD 6.36) years. A total of 691 participants (57.4%) were male, and 513 (42.6%) were female. The mean HGS was 30.0 (SD 7.53) kg for men and 19.4 (SD 5.28) kg for women. Analysis of covariance (ANCOVA) showed that factors associated with HGS among elderly males were age group, employment status, smoking status, alcohol consumption, moderate physical activity, BMI class, diabetes mellitus and self-rated health status. For females, the significant factors were age group, moderate and light physical activity, and BMI class.Conclusions: The study contributed to a better understanding of factors associated with HGS among elderly individuals in Malaysia. Consequently, HGS may be recommended as an assessment for identifying elderly individuals at risk of NCDs and poor health status.Trial RegistrationNot applicable

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Grip Strength Cut Points for Diabetes Risk Among Apparently Healthy U.S. Adults

Cited by 20 publications

References 40 publications

Associations between grip strength and incident type 2 diabetes: findings from the UK Biobank prospective cohort study

Associations between grip strength and incident type 2 diabetes: findings from the UK Biobank prospective cohort study

Association of Body Shape Index (ABSI) with Hand Grip Strength

Handgrip strength and its association with noncommunicable diseases and their risk factors among elderly individuals in Malaysia

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