Grip strength in men and women aged 50–79 years is associated with non-vertebral osteoporotic fracture during 15 years follow-up: The Tromsø Study 1994–1995

Søgaard, Anne‐Johanne; Magnus, Jeanette H.; Bjørnerem, Åshild; Holvik, Kristin; Ranhoff, Anette Hylen; Emaus, Nina; Meyer, Haakon E; Strand, Bjørn Heine

doi:10.1007/s00198-019-05191-4

Cited by 10 publications

(8 citation statements)

References 43 publications

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“…We identified 18 population-based prospective cohort studies reporting on the associations between handgrip strength and fracture risk (Electronic Supplementary Material 7 and Table 3 ). [ 2 , 3 , 15 , 20 , 27 , 28 , 31 , 36 , 38 , 54 , 60 , 62 – 65 , 70 , 74 ] Including the current study, the pooled analysis comprised 19 studies involving 220,757 participants and 9199 incident fractures (comprising 1302 hip fractures). Average age of participants ranged from 18 to 81 years with a weighted mean (SD) of 48 (16) years.…”

Section: Resultsmentioning

confidence: 99%

Handgrip strength—a risk indicator for future fractures in the general population: findings from a prospective study and meta-analysis of 19 prospective cohort studies

et al. 2020

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Evolving debate suggests that handgrip strength, a measure of muscular strength, might be associated with the risk of fractures; however, the evidence is conflicting. We aimed to assess the association of handgrip strength with the risk of fracture in the general population. Handgrip strength, measured using a dynamometer, was assessed at baseline in a population-based sample of 853 men and women aged 61–73 years in the Kuopio Ischemic Heart Disease prospective cohort. Hazard ratios (HRs) with 95% confidence intervals (CIs) were estimated for incident fractures. Incident fractures (hip, humeral, or wrist) (n = 159) occurred during a median follow-up of 16.7 years. Comparing extreme tertiles of handgrip strength, the age- and sex-adjusted hazard ratio (95% CI) for fractures was 0.80 (0.55–1.18). The association remained similar on further adjustment for other potential confounders: HR (95% CI) of 0.82 (0.55–1.21). In a meta-analysis of 19 population-based prospective cohort studies (including the current study) comprising 220,757 participants and 9199 fractures (including 1302 hip fractures), the fully adjusted relative risk (RR) (95% confidence interval, CI) for incident fractures was 0.70 (0.61–0.80) comparing the top versus bottom thirds of handgrip strength. The association remained significant after trim-and-fill correction for publication bias. The corresponding RR (95% CI) for hip fractures (9 studies) was 0.61 (0.54–0.70). Handgrip was only modestly associated with fracture risk in the primary analysis, which may be driven by the low event rate. Pooled prospective cohort evidence suggests that elevated handgrip strength is associated with reduced future fracture risk.

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Section: Resultsmentioning

confidence: 99%

Handgrip strength—a risk indicator for future fractures in the general population: findings from a prospective study and meta-analysis of 19 prospective cohort studies

et al. 2020

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“…Grip strength was associated with total hip aBMD in women and men in both age groups in the age-adjusted models, but only in women with both age groups combined in the fully adjusted models. While we and others have found grip strength to be associated with hip fractures and other osteoporotic fractures [ 24 , 26 , 40 ], it is possible that grip strength is more closely related to the risk of falling than it is to osteoporosis. Other studies have indicated that grip strength is associated with upper limb BMD [ 18 ] which we did not assess in our study.…”

Section: Discussionmentioning

confidence: 64%

“…An association between grip strength and lower limb BMD remains inconclusive [18,20]. We recently reported an inverse association between grip strength and fracture risk in the population-based Tromsø study, including hip fractures [24]. The ability to stand on one leg over time is a predictor of hip fracture risk [25,26], and several studies have indicated that one-leg stance tests are associated with BMD [21][22][23].…”

Section: Introductionmentioning

confidence: 99%

Physical capability, physical activity, and their association with femoral bone mineral density in adults aged 40 years and older: The Tromsø study 2015–2016

et al. 2021

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Since muscles can influence bone growth and vice versa, we examined if level of physical activity and physical capability tests can predict areal bone mineral density (aBMD). Both high activity level and good test performance were associated with higher aBMD, especially in women. Introduction Muscle influences bone formation and vice versa. Tests of physical capability and level of physical activity reflect various muscle qualities. We assessed the associations between total hip aBMD and physical activity as well as a range of standardized physical capability tests in an adult general population. Methods A total of 3 533 women and men aged 40-84 years, participating in the population-based cross-sectional Tromsø study in Norway in 2015-2016, were included. Linear regression was used to assess associations between aBMD and physical activity and the physical capability tests grip strength, Timed Up and Go (TUG), Short Physical Performance Battery (SPPB), and standing balance. Non-linear associations were examined in cubic spline models. Standardized regression coefficients were calculated to compare effect sizes across physical capability measures. Results In fully adjusted models, higher physical activity was positively associated with total hip aBMD in both sexes compared to a sedentary lifestyle. All tests of physical capability were associated with aBMD in women, SPPB showing the strongest association although effect sizes were too small to indicate clinically significant differences (1 point increase corresponded to an aBMD increase of 0.009 g/cm 2 , CI = 0.005 to 0.012). In men, SPPB and its subtests were associated with aBMD with chair rises showing the strongest association (1 s increase in execution time corresponded to an aBMD decrease of 0.005 g/cm 2 , CI = 0.008 to 0.002). Conclusion Physical activity was associated with aBMD, and tests of physical capability can account for some of the aBMD variations in adults aged 40 years and older, especially in women.

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“…A total of 12 studies were selected for this systematic review (Figure 1). Six studies were rated as good quality (16,18,(22)(23)(24)26) and another six rated as fair quality (17,(19)(20)(21)25,27).…”

Section: Flow Of Studies In the Reviewmentioning

confidence: 99%

“…Five studies were using the hand-held Jamar dynamometer to measure the dominant hand grip strength (19,(21)(22)(24)(25). In another study, the grip strength of the non-dominant hand was measured using the Martin Vigorimeter (26), While one study did not state the tool for hand grip strength measure (20). investigated.…”

Section: Muscle Strengthmentioning

confidence: 99%

Risk Factors Associated With Fragility Fracture Among Older Adults With Fragility Fracture: A Systematic Review

Kahar¹,

Chua²,

Singh³

et al. 2022

MJMHS

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Aim: To investigate risk factors of fragility fractures among older people. Data Sources: The electronic databases employed were PubMed, Science Direct, and Google Scholar from 2016 to December 2021. Review Method: The methodological quality of the studies was assessed using the National Institutes of Health (NIH) Quality Assessment Tool for Observational Cohort and Cross-sectional study. Two independent reviewers screened total 147 articles. Results: Twelve studies were finally included in this review that consisted of 7 cross sectional, 2 longitudinal and 3 cohort studies. Six studies were of good quality and six were fair. Studies that were of good quality showed that physical performance, muscle strength, and falls due to balance impairment were associated with an increased of fragility fractures. While the results for sarcopenia status were uncertain. Conclusion: This review suggests that physical functional related factors were main contributors to the risk of fragility fracture among older people. Lack of research in this area warrants more studies to be carried out in the future.

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Grip strength in men and women aged 50–79 years is associated with non-vertebral osteoporotic fracture during 15 years follow-up: The Tromsø Study 1994–1995

Abstract: In 50-79-year-olds who participated in the Tromsø Study (1994-95), the risk of non-vertebral osteoporotic fractures during 15 years follow-up increased by 22 percent in men and 9 percent in women per 1 SD lower grip strength. The strongest association was observed in men aged 50-64 years.

Cited by 10 publications

References 43 publications

Handgrip strength—a risk indicator for future fractures in the general population: findings from a prospective study and meta-analysis of 19 prospective cohort studies

Handgrip strength—a risk indicator for future fractures in the general population: findings from a prospective study and meta-analysis of 19 prospective cohort studies

Physical capability, physical activity, and their association with femoral bone mineral density in adults aged 40 years and older: The Tromsø study 2015–2016

Risk Factors Associated With Fragility Fracture Among Older Adults With Fragility Fracture: A Systematic Review

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