Griseofulvin

Townley, Edward R.

doi:10.1016/s0099-5428(08)60119-7

Cited by 16 publications

(7 citation statements)

References 35 publications

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“…The DSC results in Figure a corroborate the X‐ray diffraction results, which show that that the two components in the coground formulation exist as separate crystalline phases. All thermograms showed single endothermic peaks with onset temperatures around 167°C and 216°C, corresponding to literature values of pure mannitol and griseofulvin, respectively. The results indicated a slight peak broadening of the griseofulvin endotherm without any change in the heat of fusion of the ground samples, which could be because of the reduction of particle size without a loss of crystallinity of the griseofulvin during milling .…”

Section: Resultssupporting

confidence: 69%

Solid Dispersions Prepared by Continuous Cogrinding in an Air Jet Mill

Muehlenfeld

Kann

Windbergs

et al. 2013

Journal of Pharmaceutical Sciences

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Section: Resultssupporting

confidence: 69%

Solid Dispersions Prepared by Continuous Cogrinding in an Air Jet Mill

Muehlenfeld

Kann

Windbergs

et al. 2013

Journal of Pharmaceutical Sciences

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“…There is only one crystalline form for griseofulvin reported in the literature 32. Figure 2 shows that the PXRD pattern of the unmilled crystalline form matches very closely the calculated pattern, based on the Cambridge Structural Database.…”

Section: Resultssupporting

confidence: 66%

Process Induced Disorder in Crystalline Materials:Differentiating Defective Crystals from the Amorphous Form of Griseofulvin

Feng

Pinal

Carvajal

2008

Journal of Pharmaceutical Sciences

121

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“…Only an endothermic melting peak with an onset temperature of 218.0 ± 0.5°C (n = 4) was seen on the DSC thermogram. Although this onset temperature was slightly lower than that of the starting material, (219.1 ± 0.2°C), it fell within the onset melting point temperatures (217-224°C) reported in the literature (Townley 1979). This suggested that the solvent-diffusion method of particle preparation had not altered the polymorphic form of the drug.…”

Section: Microparticle Production and Characterizationsupporting

confidence: 70%

Fast-dissolving microparticles fail to show improved oral bioavailability

Wong¹,

Kellaway²,

Murdan³

2006

Journal of Pharmacy and Pharmacology

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Oral dosage forms are the preferred means of delivering drugs for systemic absorption. However, development problems occur for drugs with poor water solubility and/or gastrointestinal permeability. It is generally believed that the in-vivo bioavailability of poorly water-soluble drugs from Class II of the Biopharmaceutics Classification System can be improved by increasing the dissolution rate. We have attempted to increase the in-vivo oral bioavailability of a model Class II drug (griseofulvin) by preparing rapidly-dissolving particles. The solvent-diffusion method was used to prepare particles with hydrophilic surfactants (Brij 76/Tween 80 surfactant blend) and in-vivo studies were conducted in rats. The griseofulvin particles produced were bipyramidal in habit with a particle size of 2.18 +/- 0.12 microm; they contained crystalline drug and a relatively large proportion (12% w/w) of hydrophilic surfactant. The latter and the small particle size ensured rapid particle dispersion and dissolution in-vitro. Thus, within 30 min of the in-vitro dissolution test, the bipyramidal particles had released approximately 70% of drug compared with approximately 10% from the starting material (particle size 12.61 +/- 1.11 microm). However, the rapid and increased drug dissolution in-vitro was not translated to rapid and enhanced absorption in-vivo, and the oral bioavailability of the model drug was found to be the same from the control and from the bipyramidal particles. The poor in-vivo performance of the bipyramidal particles showed that although the dissolution rate of a Class II drug is thought to be a good indicator of its in-vivo bioavailability, this is not always the case.

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Griseofulvin

Cited by 16 publications

References 35 publications

Solid Dispersions Prepared by Continuous Cogrinding in an Air Jet Mill

Solid Dispersions Prepared by Continuous Cogrinding in an Air Jet Mill

Process Induced Disorder in Crystalline Materials:Differentiating Defective Crystals from the Amorphous Form of Griseofulvin

Fast-dissolving microparticles fail to show improved oral bioavailability

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