Gromadzenie trzewnej tkanki tłuszczowej a stężenie wybranych cytokin prozapalnych u nieotyłych mieszkańców Wrocławia

Bednarek-Tupikowska, Grażyna; Zdrojowy-Wełna, Aleksandra; Stachowska, Barbara; Kuliczkowska-Płaksej, Justyna; Matczak-Giemza, Magdalena; Kubicka, Eliza; Tworowska-Bardzińska, Urszula; Milewicz, Andrzej; Bolanowski, Marek

doi:10.5603/ep.2014.0062

Cited by 9 publications

(5 citation statements)

References 21 publications

(32 reference statements)

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“…Phillips et al found that MHO patients had lower levels of complement component 3, TNF-a, IL-6 and CRP, as well as a reduced white blood cell count and higher adiponectin [49]. Multiple studies have suggested this “favorable” inflammatory profile in MHO development [50–52], though the degree of profile is not universally agreed upon [19]. MHO show higher free fatty acid (FFA), IL-6, and CD4+ T cell levels and macrophage infiltration into adipose tissue [9].…”

Section: Metabolic Outcomesmentioning

confidence: 99%

Metabolic health and weight: Understanding metabolically unhealthy normal weight or metabolically healthy obese patients

2016

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Section: Metabolic Outcomesmentioning

confidence: 99%

Metabolic health and weight: Understanding metabolically unhealthy normal weight or metabolically healthy obese patients

2016

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“…An increase in adipose tissue, which is considered a dynamic endocrine organ, 4 is associated with an increased production of several proinflammatory cytokines and acute phase reactants, 5 such as CRP. 6 7 The association between obesity and elevated serum levels of CRP appears to be stronger in women than in men. 8 Moreover, there are also data that PROs are higher in obese patients with chronic back pain.…”

Section: Introductionmentioning

confidence: 99%

Does body mass index (BMI) influence the Ankylosing Spondylitis Disease Activity Score in axial spondyloarthritis?

et al. 2016

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ObjectiveObesity is associated with elevated C reactive protein (CRP) levels. The Ankylosing Spondylitis Disease Activity Score (ASDAS) combines patient-reported outcomes (PROs) and CRP. We evaluated the effect of body mass index (BMI) on CRP and on ASDAS, and studied if ASDAS can be used in obese axial spondyloarthritis (axSpA) patients to assess disease activity.MethodsBaseline data of patients with chronic back pain of short duration included in the SPondyloArthritis Caught Early (SPACE) cohort were used. Collected data included BMI and ASDAS. Patients were classified according to the ASAS axSpA classification criteria and BMI (overweight ≥25 and obese ≥30). Correlation and linear regression analyses were performed to assess the relation between BMI and ASDAS. Linear regression models were performed to assess if age or gender were effect modifiers in the relation between BMI and CRP, and between BMI and ASDAS.ResultsIn total, 428 patients were analysed (n=168 axSpA; n=260 no-axSpA). The mean age was 31.1 years, 36.9% were male, 26.4% were overweight and 13.3% obese, median CRP was 3 mg/L and the mean ASDAS was 2.6. Gender was the only factor modifying the relationship between BMI and CRP as BMI had an influence on CRP only in females (β=0.35; p<0.001). Correlations between BMI and CRP or PROs were generally weak, and only significant for CRP in female patients. BMI was not related to ASDAS in axSpA patients.ConclusionsASDAS is not affected by BMI in axSpA patients. Therefore, based on our data it is not necessary to take BMI in consideration when assessing disease activity using ASDAS in axSpA patients.

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“…Contrarily, recent studies have shown that IL-6 levels are not entirely linked to the amount of body fat [21,22]. Recently, Méndez-García and collaborators, after evaluating 103 individuals, observed that overweight men and women had a reduction in the serum concentration of IL-6 and that its level also did not correlate with abdominal circumference [22]; the same was observed by Bednarek-Tupikowska and colleagues [21]. Thus, since IL-6 can play both an inflammatory and anti-inflammatory functions, depending on the conditions it is secreted [23], IL-6 levels do not seem to be the most appropriate marker for subclinical inflammation [24].…”

Section: Discussionmentioning

confidence: 99%

“…This cytokine is secreted by adipose tissue and, therefore, studies suggest that IL-6 has a positive correlation with the volume of that tissue [19,20]. Contrarily, recent studies have shown that IL-6 levels are not entirely linked to the amount of body fat [21,22]. Recently, Méndez-García and collaborators, after evaluating 103 individuals, observed that overweight men and women had a reduction in the serum concentration of IL-6 and that its level also did not correlate with abdominal circumference [22]; the same was observed by Bednarek-Tupikowska and colleagues [21].…”

Section: Discussionmentioning

confidence: 99%

Short-Term Combined Exercise Improves Inflammatory Profile in the Retina of Obese Mice

Campos

Rodrigues

Pereira

et al. 2020

IJMS

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Excess of adipose tissue increases the concentration of proinflammatory cytokines, triggering a subclinical inflammatory condition. This inflammatory profile contributes to retina damage, which can lead to retinal dysfunction and reduced vision. Regularly practicing both aerobic and strength exercises is well known for promoting anti-inflammatory effects on different organs in the peripheral and central regions. However, the effects of combined physical exercise (CPE; strength + aerobic) on the inflammatory process in the retina tissue are not yet known. This study aimed to investigate the effects of CPE on the inflammatory profile of the retina in obese mice. Swiss mice were distributed into control, sedentary obese, and trained obese groups. The trained obese group was subjected to short-term CPE, 1 h/day, for 7 days. The CPE was composed of aerobic and strength exercises in the same exercise session. The strength exercise protocol consisted of 10 climbing series, with 12 ± 1 dynamic climbing movements at 70% of the maximum voluntary carrying capacity (MVCC), and the aerobic exercise protocol consisted of 30 min of treadmill running, with an intensity of 75% of the exhaust velocity. Subsequently, the retina was excised and analyzed by Western blot. Obese animals presented impairment on glucose homeostasis and elevated levels of proinflammatory proteins in the serum and retina; however, CPE was effective in reversing these parameters, independently of changes in body adiposity. Therefore, for the first time, we have shown that short-term CPE can be an important strategy to treat an inflammatory profile in the retina.

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Gromadzenie trzewnej tkanki tłuszczowej a stężenie wybranych cytokin prozapalnych u nieotyłych mieszkańców Wrocławia

Cited by 9 publications

References 21 publications

Metabolic health and weight: Understanding metabolically unhealthy normal weight or metabolically healthy obese patients

Metabolic health and weight: Understanding metabolically unhealthy normal weight or metabolically healthy obese patients

Does body mass index (BMI) influence the Ankylosing Spondylitis Disease Activity Score in axial spondyloarthritis?

Short-Term Combined Exercise Improves Inflammatory Profile in the Retina of Obese Mice

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