Ground-glass-like hepatocellular inclusions in the course of adult-onset Still’s disease

Sarı, Ayşegül; Tunakan, Mine; Özmen, Mustafa; Turkkan, Ebru

doi:10.1007/s10165-009-0233-6

Cited by 3 publications

(3 citation statements)

References 12 publications

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“…These findings are not specific and are often found in AIH or DILI. Ground glass‐like cytoplasmic inclusions, which are associated with venous outflow impairment, are also observed in AOSD 11 . A typical feature of AIH is the presence of interface hepatitis, piecemeal necrosis, plasma cell‐rich infiltrates, and emperipolesis 12 .…”

Section: Discussionmentioning

confidence: 98%

“…Ground glass-like cytoplasmic inclusions, which are associated with venous outflow impairment, are also observed in AOSD. 11 A typical feature of AIH is the presence of interface hepatitis, piecemeal necrosis, plasma cell-rich infiltrates, and emperipolesis. 12 Emperipolesis is the engulfment of lymphocytes by hepatocytes, probably reflecting immune-mediated injury that occurs in several liver diseases (including AIH, chronic hepatitis B, and chronic hepatitis C).…”

Section: Discussionmentioning

confidence: 99%

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Autoimmune hepatitis complicated by adult‐onset Still's disease during treatment with tocilizumab: A case report from acute onset to recurrence

Uchihara

Suzuki

Koya

et al. 2023

Clinical Case Reports

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Adult-onset Still's disease (AOSD) is a systemic inflammatory disorder of unknown etiology that usually affects young adults. 1 Spiking fever, arthritis, and evanescent rash are commonly observed during the course of the disease. Other frequently observed clinical features include sore throat, hepatosplenomegaly, lymphadenopathy, and serositis. 2 Adult-onset Still's disease is usually complicated by liver dysfunction. 3 However, cases of autoimmune hepatitis (AIH) complicated by AOSD are rare, and discerning the cause of liver dysfunction as AOSD or AIH is difficult. This was a very rare case that could be followed up from acute onset to recurrence of AIH complicated by AOSD. Herein, we report a case of AIH complicated by AOSD that was successfully diagnosed by a liver biopsy.

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Section: Discussionmentioning

confidence: 98%

Section: Discussionmentioning

confidence: 99%

Autoimmune hepatitis complicated by adult‐onset Still's disease during treatment with tocilizumab: A case report from acute onset to recurrence

Uchihara

Suzuki

Koya

et al. 2023

Clinical Case Reports

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“…It is hypothesized that ground glass change in these settings is a result of glycogen accumulation due to enzymatic inhibition in glucose metabolism ( 4 ). Ground glass-like inclusion may thus reflect subcellular hepatocyte injury with abnormal glycogen deposition ( 10 ). Electron microscopy revealed glycogen accumulation with degenerated organelles.…”

Section: Discussionmentioning

confidence: 99%

Ground glass-like inclusions: associated with liver toxicity

Denız

2020

TJPATH

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Objective: The etiology of ground glass-like inclusions is heterogenous and the pathology has been described in various conditions including HBV infection, Lafora's disease, fibrinogen storage disease, type IV glycogenosis, and alcohol reversion therapy. Similar ground glass-like inclusions are also associated with immunosuppressed conditions and multiple medications, for which the clinical significance is still unclear. Additional cases, some with previously unreported unique etiologies, and their follow-up were described in this study. Materials and Methods: Eleven cases were examined between 2008 and 2019 for this study. The clinical data and histologic slides were reviewed. All of the cases were negative for Hepatitis B virus. None of the patients declared alcohol intake or a history of epilepsy. Results: Liver histology showed mild lobular inflammation in most of the cases (72%). Ground glass-like hepatocytes were distributed in the patchy-panlobular, periportal, and centrizonal pattern at 55%, 27%, and 18%, respectively. Clinical history revealed medication use in nine (82%) patients including NSAIDs, steroids, and chemotherapy. Ground glass-like inclusions were related to herbal toxicity in two of the patients. Liver function tests were elevated in all of the cases. Follow-up data revealed four patients with malignancy who died of their cancer. Seven patients showed resolution of elevated liver enzymes with a median follow-up period of 37 months (range 7-132 months). Conclusions: Medication is the most relevant etiology for the development of these inclusions. Ground glass-like inclusions may also seen in herbal toxicity. Transplantation was not an etiologic factor in our patients. Most of the patients displayed an indolent course with resolution of the elevated transaminases.

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Autoimmune hepatitis complicated by adult-onset Still’s disease during treatment with tocilizumab: a case report from acute onset to recurrence

Uchihara¹,

Suzuki²,

Koya

et al. 2023

Preprint

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Ground-glass-like hepatocellular inclusions in the course of adult-onset Still’s disease

Cited by 3 publications

References 12 publications

Autoimmune hepatitis complicated by adult‐onset Still's disease during treatment with tocilizumab: A case report from acute onset to recurrence

Autoimmune hepatitis complicated by adult‐onset Still's disease during treatment with tocilizumab: A case report from acute onset to recurrence

Ground glass-like inclusions: associated with liver toxicity

Autoimmune hepatitis complicated by adult-onset Still’s disease during treatment with tocilizumab: a case report from acute onset to recurrence

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