Groundwater characterization and non-carcinogenic and carcinogenic health risk assessment of nitrate exposure in the Mahanadi River Basin of India

Pasupuleti, Srinivas; Singha, Soumya S.; Singha, Sudhakar; Kumar, Suresh; Singh, Rambabu; Dhada, Indramani

doi:10.1016/j.jenvman.2022.115746

Cited by 32 publications

(7 citation statements)

References 56 publications

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“…On the other hand, body weight (BW) was identified as the most insignificant parameter in the estimated THI, exhibiting a total variability of −34 % for adults and −16.90 % for children. In other words, an increase in body weight can significantly reduce potential health risks associated with TMs exposure [ 54 ].…”

Section: Resultsmentioning

confidence: 99%

Bioavailability and health risk of pollutants around a controlled landfill in Morocco: Synergistic effects of landfilling and intensive agriculture

El Fadili,

Ben Ali,

Rahman

et al. 2024

Heliyon

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Section: Resultsmentioning

confidence: 99%

Bioavailability and health risk of pollutants around a controlled landfill in Morocco: Synergistic effects of landfilling and intensive agriculture

El Fadili,

Ben Ali,

Rahman

et al. 2024

Heliyon

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“…The majority of neurological illnesses are mostly caused by prenatal or postnatal exposure to environmental toxins [24]. Some experimental and clinical studies have also reported the adverse effect of nitrates on health by targeting various physiological and metabolic functions in the body [8, [25][26][27]. Epidemiological studies have shown that high levels of nitrate can be toxic and its chronic exposure may affect brain development [8,27].…”

Section: Discussionmentioning

confidence: 99%

Crosstalk Between miRNA and Protein Expression Profiles in Nitrate-Exposed Brain Cells

et al. 2023

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Growing evidence reported a strong association between the ingestion of nitrate and adverse health consequences in humans, including its detrimental impact on the developing brain. The present study identi ed miRNAs and proteins in SH-SY5Y human neuroblastoma cells and HMC3 human microglial cells using high throughput techniques in response to nitrate level most prevalent in the environment (mainly India) (X) and an exceptionally high nitrate level (5X) that can be reached in the near future. Cells were exposed to mixtures of nitrates for 72 h at doses of X and 5X, 320 mg/L and 1600 mg/L, respectively. OpenArray and LCMS analysis revealed that maximum deregulation in miRNAs and proteins was found in cells exposed to 5X dose. Top deregulated miRNAs include miR-34b, miR-34c, miR-155, miR-143, and miR-145. The proteomic pro les of both cell types include proteins that are potential targets of deregulated miRNAs. These miRNAs and their targeted proteins are involved in multiple functions, including cellular senescence, cell cycle, apoptosis, neuronal disorders, brain development, and homeostasis. Further, measuring mitochondrial bioenergetics in cells exposed to nitrate using a Seahorse XFp ux analyzer revealed that a 5X dose causes a signi cant reduction in oxygen consumption rate (OCR) and other bioenergetics parameters in both cell types. In summary, our studies have demonstrated that 5X dose of nitrate signi cantly alters cellular physiology and functions by deregulating several miRNAs and proteins. However, X dose of nitrate that is most prevalent in the environment has not caused any adverse effects on any cell type.

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“…In order to conduct this, it is important to maximize the divergence of each class’s mean from the means of the other groups while limiting the average deviation of each class from the mean of the class. In other words, the method seeks to reduce the variance within classes while increasing the variety within classes [ 36 , 37 ].…”

Section: Methodsmentioning

confidence: 99%

Estimation of Polycyclic Aromatic Hydrocarbons in Groundwater from Campania Plain: Spatial Distribution, Source Attribution and Health Cancer Risk Evaluation

Montuori

Rosa

Pellegrino

et al. 2023

Toxics

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The aim of this study was to evaluate the concentrations of polycyclic aromatic hydrocarbons (PAHs) in 1168 groundwater samples of the Campania Plain (Southern Italy), taken using a municipal environmental pressure index (MIEP), and to analyze the distribution of these compounds to determine source PAHs using ratios of isomers diagnostic. Lastly, this study also aimed to estimate the potential health cancer risk in groundwaters. The data indicated that the highest concentration of PAHs was found in groundwater from Caserta Province and the contents of BghiP, Phe, and Nap were detected in the samples. The spatial distribution of these pollutants was evaluated using the Jenks method; moreover, the data indicated that incremental lifetime cancer risk ILCRingestion ranged from 7.31 × 10−20 to 4.96 × 10−19, while ILCRdermal ranged from 4.32 × 10−11 to 2.93 × 10−10. These research findings may provide information about the Campania Plain’s groundwater quality and aid in the development of preventative measures to lessen PAH contamination in groundwater.

show abstract

Groundwater characterization and non-carcinogenic and carcinogenic health risk assessment of nitrate exposure in the Mahanadi River Basin of India

Cited by 32 publications

References 56 publications

Bioavailability and health risk of pollutants around a controlled landfill in Morocco: Synergistic effects of landfilling and intensive agriculture

Bioavailability and health risk of pollutants around a controlled landfill in Morocco: Synergistic effects of landfilling and intensive agriculture

Crosstalk Between miRNA and Protein Expression Profiles in Nitrate-Exposed Brain Cells

Estimation of Polycyclic Aromatic Hydrocarbons in Groundwater from Campania Plain: Spatial Distribution, Source Attribution and Health Cancer Risk Evaluation

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